These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

56 related articles for article (PubMed ID: 20095045)

  • 1. Segmental motions of rat thymidylate synthase leading to half-the-sites behavior.
    Swiniarska M; Leś A; Rode W; Cieśla J; Millán-Pacheco C; Blake IO; Pastor N
    Biopolymers; 2010 Jun; 93(6):549-59. PubMed ID: 20095045
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.
    Finer-Moore JS; Anderson AC; O'Neil RH; Costi MP; Ferrari S; Krucinski J; Stroud RM
    Acta Crystallogr D Biol Crystallogr; 2005 Oct; 61(Pt 10):1320-34. PubMed ID: 16204883
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Domain motions and the open-to-closed conformational transition of an enzyme: a normal mode analysis of S-adenosyl-L-homocysteine hydrolase.
    Wang M; Borchardt RT; Schowen RL; Kuczera K
    Biochemistry; 2005 May; 44(19):7228-39. PubMed ID: 15882061
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cooperative fluctuations and subunit communication in tryptophan synthase.
    Bahar I; Jernigan RL
    Biochemistry; 1999 Mar; 38(12):3478-90. PubMed ID: 10090734
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Computational study of IAG-nucleoside hydrolase: determination of the preferred ground state conformation and the role of active site residues.
    Mazumder-Shivakumar D; Bruice TC
    Biochemistry; 2005 May; 44(21):7805-17. PubMed ID: 15909995
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.
    Sotelo-Mundo RR; Ciesla J; Dzik JM; Rode W; Maley F; Maley GF; Hardy LW; Montfort WR
    Biochemistry; 1999 Jan; 38(3):1087-94. PubMed ID: 9894005
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The active-inactive transition of human thymidylate synthase: targeted molecular dynamics simulations.
    Salo-Ahen OM; Wade RC
    Proteins; 2011 Oct; 79(10):2886-99. PubMed ID: 21905113
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
    Sotelo-Mundo RR; Changchien L; Maley F; Montfort WR
    J Biochem Mol Toxicol; 2006; 20(2):88-92. PubMed ID: 16615077
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of enzyme motions by solution NMR relaxation dispersion.
    Loria JP; Berlow RB; Watt ED
    Acc Chem Res; 2008 Feb; 41(2):214-21. PubMed ID: 18281945
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Subunit complementation of thymidylate synthase in Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase.
    Chanama M; Chitnumsub P; Yuthavong Y
    Mol Biochem Parasitol; 2005 Jan; 139(1):83-90. PubMed ID: 15610822
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
    Anderson AC; Perry KM; Freymann DM; Stroud RM
    J Mol Biol; 2000 Mar; 297(3):645-57. PubMed ID: 10731418
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O; Schormann N; Chattopadhyay D
    Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
    Sage CR; Rutenber EE; Stout TJ; Stroud RM
    Biochemistry; 1996 Dec; 35(50):16270-81. PubMed ID: 8973201
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase.
    Elcock AH; Potter MJ; Matthews DA; Knighton DR; McCammon JA
    J Mol Biol; 1996 Sep; 262(3):370-4. PubMed ID: 8845002
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
    Spencer HT; Villafranca JE; Appleman JR
    Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping.
    Sheu SH; Kaya T; Waxman DJ; Vajda S
    Biochemistry; 2005 Feb; 44(4):1193-209. PubMed ID: 15667213
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
    Sayre PH; Finer-Moore JS; Fritz TA; Biermann D; Gates SB; MacKellar WC; Patel VF; Stroud RM
    J Mol Biol; 2001 Nov; 313(4):813-29. PubMed ID: 11697906
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
    Jones TR; Varney MD; Webber SE; Lewis KK; Marzoni GP; Palmer CL; Kathardekar V; Welsh KM; Webber S; Matthews DA; Appelt K; Smith WW; Janson CA; Villafranca JE; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Moomaw EW; Bartlett CA; Morse CA
    J Med Chem; 1996 Feb; 39(4):904-17. PubMed ID: 8632414
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inter-Active Site Communication Mediated by the Dimer Interface β-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase.
    Sapienza PJ; Popov KI; Mowrey DD; Falk BT; Dokholyan NV; Lee AL
    Biochemistry; 2019 Jul; 58(30):3302-3313. PubMed ID: 31283187
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.
    Hyatt DC; Maley F; Montfort WR
    Biochemistry; 1997 Apr; 36(15):4585-94. PubMed ID: 9109668
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 3.