BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

277 related articles for article (PubMed ID: 20118234)

  • 1. The N terminus of monoamine transporters is a lever required for the action of amphetamines.
    Sucic S; Dallinger S; Zdrazil B; Weissensteiner R; Jørgensen TN; Holy M; Kudlacek O; Seidel S; Cha JH; Gether U; Newman AH; Ecker GF; Freissmuth M; Sitte HH
    J Biol Chem; 2010 Apr; 285(14):10924-38. PubMed ID: 20118234
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter.
    Kern C; Erdem FA; El-Kasaby A; Sandtner W; Freissmuth M; Sucic S
    J Biol Chem; 2017 Mar; 292(9):3603-3613. PubMed ID: 28104804
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.
    Guptaroy B; Zhang M; Bowton E; Binda F; Shi L; Weinstein H; Galli A; Javitch JA; Neubig RR; Gnegy ME
    Mol Pharmacol; 2009 Mar; 75(3):514-24. PubMed ID: 19098122
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle.
    Korkhov VM; Holy M; Freissmuth M; Sitte HH
    J Biol Chem; 2006 May; 281(19):13439-13448. PubMed ID: 16527819
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Putative drug binding conformations of monoamine transporters.
    Ravna AW; Sylte I; Kristiansen K; Dahl SG
    Bioorg Med Chem; 2006 Feb; 14(3):666-75. PubMed ID: 16216517
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The external gate of the human and Drosophila serotonin transporters requires a basic/acidic amino acid pair for 3,4-methylenedioxymethamphetamine (MDMA) translocation and the induction of substrate efflux.
    Sealover NR; Felts B; Kuntz CP; Jarrard RE; Hockerman GH; Lamb PW; Barker EL; Henry LK
    Biochem Pharmacol; 2016 Nov; 120():46-55. PubMed ID: 27638414
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.
    Koban F; El-Kasaby A; Häusler C; Stockner T; Simbrunner BM; Sitte HH; Freissmuth M; Sucic S
    J Biol Chem; 2015 May; 290(21):13263-78. PubMed ID: 25869136
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter.
    Laursen L; Severinsen K; Kristensen KB; Periole X; Overby M; Müller HK; Schiøtt B; Sinning S
    J Biol Chem; 2018 Mar; 293(10):3510-3523. PubMed ID: 29352106
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.
    El-Kasaby A; Just H; Malle E; Stolt-Bergner PC; Sitte HH; Freissmuth M; Kudlacek O
    J Biol Chem; 2010 Dec; 285(50):39201-10. PubMed ID: 20889976
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of an allosteric modulator of the serotonin transporter with novel mechanism of action.
    Kortagere S; Fontana AC; Rose DR; Mortensen OV
    Neuropharmacology; 2013 Sep; 72():282-90. PubMed ID: 23632081
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.
    Steinkellner T; Montgomery TR; Hofmaier T; Kudlacek O; Yang JW; Rickhag M; Jung G; Lubec G; Gether U; Freissmuth M; Sitte HH
    J Neurosci; 2015 May; 35(21):8258-71. PubMed ID: 26019340
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities.
    Sweeney CG; Tremblay BP; Stockner T; Sitte HH; Melikian HE
    J Biol Chem; 2017 Jan; 292(4):1302-1309. PubMed ID: 27986813
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A quantitative model of amphetamine action on the 5-HT transporter.
    Sandtner W; Schmid D; Schicker K; Gerstbrein K; Koenig X; Mayer FP; Boehm S; Freissmuth M; Sitte HH
    Br J Pharmacol; 2014 Feb; 171(4):1007-18. PubMed ID: 24251585
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation.
    Rannversson H; Wilson P; Kristensen KB; Sinning S; Kristensen AS; Strømgaard K; Andersen J
    J Biol Chem; 2015 Jun; 290(23):14582-94. PubMed ID: 25903124
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Thermal Unfolding of the Human Serotonin Transporter: Differential Effect by Stabilizing and Destabilizing Mutations and Cholesterol on Thermodynamic and Kinetic Stability.
    Ponleitner M; Szöllősi D; El-Kasaby A; Koban F; Freissmuth M; Stockner T
    Mol Pharmacol; 2022 Feb; 101(2):95-105. PubMed ID: 34866045
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.
    Sarker S; Weissensteiner R; Steiner I; Sitte HH; Ecker GF; Freissmuth M; Sucic S
    Mol Pharmacol; 2010 Dec; 78(6):1026-35. PubMed ID: 20829432
    [TBL] [Abstract][Full Text] [Related]  

  • 17. N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux.
    Khoshbouei H; Sen N; Guptaroy B; Johnson L'; Lund D; Gnegy ME; Galli A; Javitch JA
    PLoS Biol; 2004 Mar; 2(3):E78. PubMed ID: 15024426
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter.
    Seddik A; Geerke DP; Stockner T; Holy M; Kudlacek O; Cozzi NV; Ruoho AE; Sitte HH; Ecker GF
    Mol Inform; 2017 May; 36(5-6):. PubMed ID: 27860344
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamines and non-amphetamines.
    Hilber B; Scholze P; Dorostkar MM; Sandtner W; Holy M; Boehm S; Singer EA; Sitte HH
    Neuropharmacology; 2005 Nov; 49(6):811-9. PubMed ID: 16185723
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition.
    Walline CC; Nichols DE; Carroll FI; Barker EL
    J Pharmacol Exp Ther; 2008 Jun; 325(3):791-800. PubMed ID: 18354055
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.