BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

316 related articles for article (PubMed ID: 20133743)

  • 1. Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.
    Ogura T; Tong KI; Mio K; Maruyama Y; Kurokawa H; Sato C; Yamamoto M
    Proc Natl Acad Sci U S A; 2010 Feb; 107(7):2842-7. PubMed ID: 20133743
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A; Motohashi H
    Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response.
    Tong KI; Padmanabhan B; Kobayashi A; Shang C; Hirotsu Y; Yokoyama S; Yamamoto M
    Mol Cell Biol; 2007 Nov; 27(21):7511-21. PubMed ID: 17785452
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
    McMahon M; Thomas N; Itoh K; Yamamoto M; Hayes JD
    J Biol Chem; 2006 Aug; 281(34):24756-68. PubMed ID: 16790436
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex.
    Baird L; Llères D; Swift S; Dinkova-Kostova AT
    Proc Natl Acad Sci U S A; 2013 Sep; 110(38):15259-64. PubMed ID: 23986495
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1.
    Padmanabhan B; Tong KI; Kobayashi A; Yamamoto M; Yokoyama S
    J Synchrotron Radiat; 2008 May; 15(Pt 3):273-6. PubMed ID: 18421157
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Keap1 degradation by autophagy for the maintenance of redox homeostasis.
    Taguchi K; Fujikawa N; Komatsu M; Ishii T; Unno M; Akaike T; Motohashi H; Yamamoto M
    Proc Natl Acad Sci U S A; 2012 Aug; 109(34):13561-6. PubMed ID: 22872865
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.
    Taguchi K; Motohashi H; Yamamoto M
    Genes Cells; 2011 Feb; 16(2):123-40. PubMed ID: 21251164
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
    Kobayashi A; Kang MI; Okawa H; Ohtsuji M; Zenke Y; Chiba T; Igarashi K; Yamamoto M
    Mol Cell Biol; 2004 Aug; 24(16):7130-9. PubMed ID: 15282312
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cysteine-based regulation of the CUL3 adaptor protein Keap1.
    Sekhar KR; Rachakonda G; Freeman ML
    Toxicol Appl Pharmacol; 2010 Apr; 244(1):21-6. PubMed ID: 19560482
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2.
    McMahon M; Swift SR; Hayes JD
    Toxicol Appl Pharmacol; 2018 Dec; 360():45-57. PubMed ID: 30261176
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural analysis of the complex of Keap1 with a prothymosin alpha peptide.
    Padmanabhan B; Nakamura Y; Yokoyama S
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2008 Apr; 64(Pt 4):233-8. PubMed ID: 18391415
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1.
    Unni S; Deshmukh P; Krishnappa G; Kommu P; Padmanabhan B
    FEBS J; 2021 Mar; 288(5):1599-1613. PubMed ID: 32672401
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.
    Padmanabhan B; Tong KI; Ohta T; Nakamura Y; Scharlock M; Ohtsuji M; Kang MI; Kobayashi A; Yokoyama S; Yamamoto M
    Mol Cell; 2006 Mar; 21(5):689-700. PubMed ID: 16507366
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes.
    Kang MI; Kobayashi A; Wakabayashi N; Kim SG; Yamamoto M
    Proc Natl Acad Sci U S A; 2004 Feb; 101(7):2046-51. PubMed ID: 14764898
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.
    Kobayashi A; Kang MI; Watai Y; Tong KI; Shibata T; Uchida K; Yamamoto M
    Mol Cell Biol; 2006 Jan; 26(1):221-9. PubMed ID: 16354693
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.
    Yamamoto T; Suzuki T; Kobayashi A; Wakabayashi J; Maher J; Motohashi H; Yamamoto M
    Mol Cell Biol; 2008 Apr; 28(8):2758-70. PubMed ID: 18268004
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.
    He X; Ma Q
    J Pharmacol Exp Ther; 2010 Jan; 332(1):66-75. PubMed ID: 19808700
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
    Komatsu M; Kurokawa H; Waguri S; Taguchi K; Kobayashi A; Ichimura Y; Sou YS; Ueno I; Sakamoto A; Tong KI; Kim M; Nishito Y; Iemura S; Natsume T; Ueno T; Kominami E; Motohashi H; Tanaka K; Yamamoto M
    Nat Cell Biol; 2010 Mar; 12(3):213-23. PubMed ID: 20173742
    [TBL] [Abstract][Full Text] [Related]  

  • 20. NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation.
    He X; Ma Q
    Mol Pharmacol; 2009 Dec; 76(6):1265-78. PubMed ID: 19786557
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.