BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 20138520)

  • 1. The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism.
    Jain HV; Rasheed R; Kalman TI
    Bioorg Med Chem Lett; 2010 Mar; 20(5):1648-51. PubMed ID: 20138520
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nucleophilic participation in the transition state for human thymidine phosphorylase.
    Birck MR; Schramm VL
    J Am Chem Soc; 2004 Mar; 126(8):2447-53. PubMed ID: 14982453
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ternary complex crystal structures of glycogen phosphorylase with the transition state analogue nojirimycin tetrazole and phosphate in the T and R states.
    Mitchell EP; Withers SG; Ermert P; Vasella AT; Garman EF; Oikonomakos NG; Johnson LN
    Biochemistry; 1996 Jun; 35(23):7341-55. PubMed ID: 8652510
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59).
    Bronckaers A; Aguado L; Negri A; Camarasa MJ; Balzarini J; Pérez-Pérez MJ; Gago F; Liekens S
    Biochem Pharmacol; 2009 Aug; 78(3):231-40. PubMed ID: 19389384
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis.
    Bzowska A; Koellner G; Wielgus-Kutrowska B; Stroh A; Raszewski G; Holý A; Steiner T; Frank J
    J Mol Biol; 2004 Sep; 342(3):1015-32. PubMed ID: 15342253
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Towards new thymidine phosphorylase/PD-ECGF inhibitors based on the transition state of the enzyme reaction.
    Priego EM; Mendieta J; Gago F; Balzarini J; De Clercq E; Camarasa MJ; Pérez-Pérez MJ
    Nucleosides Nucleotides Nucleic Acids; 2003; 22(5-8):951-3. PubMed ID: 14565319
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Syntheses of 1-[2-(Phosphonomethoxy)Alkyl] thymine monophosphates and an evaluation of their inhibitory activity toward human thymidine phosphorylase.
    Pomeisl K; Horská K; Pohl R; Blažek J; Krečmerová M
    Nucleosides Nucleotides Nucleic Acids; 2012; 31(3):159-71. PubMed ID: 22356232
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.
    Mendieta J; Martín-Santamaría S; Priego EM; Balzarini J; Camarasa MJ; Pérez-Pérez MJ; Gago F
    Biochemistry; 2004 Jan; 43(2):405-14. PubMed ID: 14717594
    [TBL] [Abstract][Full Text] [Related]  

  • 9. [Influence of the thymidine phosphorylase (platelet-derived endothelial cell growth factor) on tumor angiogenesis. Catalytic activity of enzyme inhibitors].
    Miszczak-Zaborska E; Smolarek M; Bartkowiak J
    Postepy Biochem; 2010; 56(1):61-6. PubMed ID: 20499682
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rational design of bis-indolylmethane-oxadiazole hybrids as inhibitors of thymidine phosphorylase.
    Taha M; Rashid U; Imran S; Ali M
    Bioorg Med Chem; 2018 Jul; 26(12):3654-3663. PubMed ID: 29853339
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines.
    Votruba I; Pomeisl K; Tloust'ová E; Holý A; Otová B
    Biochem Pharmacol; 2005 May; 69(10):1517-21. PubMed ID: 15857616
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase.
    Pomeisl K; Holý A; Votruba I
    Nucleic Acids Symp Ser (Oxf); 2008; (52):657-8. PubMed ID: 18776551
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine phosphorylase.
    Yano S; Kazuno H; Sato T; Suzuki N; Emura T; Wierzba K; Yamashita J; Tada Y; Yamada Y; Fukushima M; Asao T
    Bioorg Med Chem; 2004 Jul; 12(13):3443-50. PubMed ID: 15186830
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase.
    Rajabi M; Mansell D; Freeman S; Bryce RA
    Eur J Med Chem; 2011 Apr; 46(4):1165-71. PubMed ID: 21324566
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Kinetics mechanism and regulation of native human hepatic thymidine phosphorylase.
    Oh T; El Kouni MH
    Int J Biochem Cell Biol; 2019 May; 110():122-129. PubMed ID: 30849523
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and in vitro evaluation of 5-fluoro-6-[(2-iminopyrrolidin-1-YL)methyl]uracil, TPI(F): an inhibitor of human thymidine phosphorylase (TP).
    Grierson JR; Brockenbrough JS; Rasey JS; Wiens L; Vesselle H
    Nucleosides Nucleotides Nucleic Acids; 2010 Jan; 29(1):49-54. PubMed ID: 20391192
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.
    Singh V; Shi W; Evans GB; Tyler PC; Furneaux RH; Almo SC; Schramm VL
    Biochemistry; 2004 Jan; 43(1):9-18. PubMed ID: 14705926
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.
    Nencka R; Votruba I; Hrebabecký H; Tloust'ová E; Horská K; Masojídková M; Holý A
    Bioorg Med Chem Lett; 2006 Mar; 16(5):1335-7. PubMed ID: 16337119
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase.
    Hatano A; Harano A; Takigawa Y; Naramoto Y; Toda K; Nakagomi Y; Yamada H
    Bioorg Med Chem; 2008 Apr; 16(7):3866-70. PubMed ID: 18272369
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase.
    Pomeisl K; Holý A; Votruba I; Pohl R
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1364-7. PubMed ID: 18221873
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.