BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

97 related articles for article (PubMed ID: 20138768)

  • 21. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor.
    Roehrig S; Straub A; Pohlmann J; Lampe T; Pernerstorfer J; Schlemmer KH; Reinemer P; Perzborn E
    J Med Chem; 2005 Sep; 48(19):5900-8. PubMed ID: 16161994
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Characterization and comparative evaluation of a novel PAI-1 inhibitor.
    Gils A; Stassen JM; Nar H; Kley JT; Wienen W; Ries UJ; Declerck PJ
    Thromb Haemost; 2002 Jul; 88(1):137-43. PubMed ID: 12152654
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity.
    Koshio H; Hirayama F; Ishihara T; Taniuchi Y; Sato K; Sakai-Moritani Y; Kaku S; Kawasaki T; Matsumoto Y; Sakamoto S; Tsukamoto S
    Bioorg Med Chem; 2004 May; 12(9):2179-91. PubMed ID: 15080918
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Inhibition of PAI-1: a new anti-thrombotic approach.
    Wu Q; Zhao Z
    Curr Drug Targets Cardiovasc Haematol Disord; 2002 Jun; 2(1):27-42. PubMed ID: 12769655
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand.
    Choi-Sledeski YM; Kearney R; Poli G; Pauls H; Gardner C; Gong Y; Becker M; Davis R; Spada A; Liang G; Chu V; Brown K; Collussi D; Leadley R; Rebello S; Moxey P; Morgan S; Bentley R; Kasiewski C; Maignan S; Guilloteau JP; Mikol V
    J Med Chem; 2003 Feb; 46(5):681-4. PubMed ID: 12593648
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery of inhibitors of plasminogen activator inhibitor-1: structure-activity study of 5-nitro-2-phenoxybenzoic acid derivatives.
    Pandya V; Jain M; Chakrabarti G; Soni H; Parmar B; Chaugule B; Patel J; Joshi J; Joshi N; Rath A; Raviya M; Shaikh M; Sairam KV; Patel H; Patel P
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5701-6. PubMed ID: 21880486
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.
    Nar H; Bauer M; Stassen JM; Lang D; Gils A; Declerck PJ
    J Mol Biol; 2000 Mar; 297(3):683-95. PubMed ID: 10731421
    [TBL] [Abstract][Full Text] [Related]  

  • 28. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE
    J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Characterization of a small molecule PAI-1 inhibitor, ZK4044.
    Liang A; Wu F; Tran K; Jones SW; Deng G; Ye B; Zhao Z; Snider RM; Dole WP; Morser J; Wu Q
    Thromb Res; 2005; 115(4):341-50. PubMed ID: 15668194
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
    Phillips GB; Buckman BO; Davey DD; Eagen KA; Guilford WJ; Hinchman J; Ho E; Koovakkat S; Liang A; Light DR; Mohan R; Ng HP; Post JM; Shaw KJ; Smith D; Subramanyam B; Sullivan ME; Trinh L; Vergona R; Walters J; White K; Whitlow M; Wu S; Xu W; Morrissey MM
    J Med Chem; 1998 Sep; 41(19):3557-62. PubMed ID: 9733480
    [No Abstract]   [Full Text] [Related]  

  • 31. Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.
    Lin J; Deng H; Jin L; Pandey P; Quinn J; Cantin S; Rynkiewicz MJ; Gorga JC; Bibbins F; Celatka CA; Nagafuji P; Bannister TD; Meyers HV; Babine RE; Hayward NJ; Weaver D; Benjamin H; Stassen F; Abdel-Meguid SS; Strickler JE
    J Med Chem; 2006 Dec; 49(26):7781-91. PubMed ID: 17181160
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors.
    Groebke Zbinden K; Banner DW; Ackermann J; D'Arcy A; Kirchhofer D; Ji YH; Tschopp TB; Wallbaum S; Weber L
    Bioorg Med Chem Lett; 2005 Feb; 15(3):817-22. PubMed ID: 15664864
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Anti-thrombotic effect of a PAI-1 inhibitor in rats given endotoxin.
    Abrahamsson T; Nerme V; Strömqvist M; Akerblom B; Legnehed A; Pettersson K; Westin Eriksson A
    Thromb Haemost; 1996 Jan; 75(1):118-26. PubMed ID: 8713790
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.
    Lu T; Markotan T; Coppo F; Tomczuk B; Crysler C; Eisennagel S; Spurlino J; Gremminger L; Soll RM; Giardino EC; Bone R
    Bioorg Med Chem Lett; 2004 Jul; 14(14):3727-31. PubMed ID: 15203151
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Distal hinge of plasminogen activator inhibitor-1 involves its latency transition and specificities toward serine proteases.
    Wang Q; Shaltiel S
    BMC Biochem; 2003 Jul; 4():5. PubMed ID: 12848892
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2.
    Quan ML; Ellis CD; Liauw AY; Alexander RS; Knabb RM; Lam G; Wright MR; Wong PC; Wexler RR
    J Med Chem; 1999 Jul; 42(15):2760-73. PubMed ID: 10425087
    [TBL] [Abstract][Full Text] [Related]  

  • 37. New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation.
    De Nanteuil G; Lila-Ambroise C; Rupin A; Vallez MO; Verbeuren TJ
    Bioorg Med Chem Lett; 2003 May; 13(10):1705-8. PubMed ID: 12729646
    [TBL] [Abstract][Full Text] [Related]  

  • 38. VLHL plasminogen activator inhibitor spontaneously reactivates from the latent to active form.
    Jankun J; Aleem AM; Selman SH; Basrur V; Skrzypczak-Jankun E
    Int J Mol Med; 2009 Jan; 23(1):57-63. PubMed ID: 19082507
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
    Costanzo MJ; Yabut SC; Zhang HC; White KB; de Garavilla L; Wang Y; Minor LK; Tounge BA; Barnakov AN; Lewandowski F; Milligan C; Spurlino JC; Abraham WM; Boswell-Smith V; Page CP; Maryanoff BE
    Bioorg Med Chem Lett; 2008 Mar; 18(6):2114-21. PubMed ID: 18272363
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Plasminogen activator inhibitor-1 mRNA expression in cultured pigmented ciliary epithelial cells of the porcine eye.
    Meyer MW; von Depka M; Wilhelm C; Schröder A; Erb C
    Graefes Arch Clin Exp Ophthalmol; 2002 Aug; 240(8):679-86. PubMed ID: 12192463
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.