BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 20143425)

  • 21. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
    Yang T; Arslanova D; Gu Y; Augelli-Szafran C; Xia W
    Mol Brain; 2008 Nov; 1():15. PubMed ID: 18983676
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation.
    Eckert A; Steiner B; Marques C; Leutz S; Romig H; Haass C; Müller WE
    J Neurosci Res; 2001 Apr; 64(2):183-92. PubMed ID: 11288146
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.
    Sheng B; Gong K; Niu Y; Liu L; Yan Y; Lu G; Zhang L; Hu M; Zhao N; Zhang X; Tang P; Gong Y
    Free Radic Biol Med; 2009 May; 46(10):1362-75. PubMed ID: 19264123
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.
    Mitsuishi Y; Hasegawa H; Matsuo A; Araki W; Suzuki T; Tagami S; Okochi M; Takeda M; Roepman R; Nishimura M
    J Biol Chem; 2010 May; 285(20):14920-14931. PubMed ID: 20299451
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia.
    Jung S; Nah J; Han J; Choi SG; Kim H; Park J; Pyo HK; Jung YK
    J Neurochem; 2016 Jun; 137(5):770-81. PubMed ID: 26924229
    [TBL] [Abstract][Full Text] [Related]  

  • 26. TASTPM mice expressing amyloid precursor protein and presenilin-1 mutant transgenes are sensitive to γ-secretase modulation and amyloid-β₄₂ lowering by GSM-10h.
    Hussain I; Harrison DC; Hawkins J; Chapman T; Marshall I; Facci L; Ahmed S; Brackenborough K; Skaper SD; Mead TL; Smith BB; Giblin GM; Hall A; Gonzalez MI; Richardson JC
    Neurodegener Dis; 2011; 8(1-2):15-24. PubMed ID: 20689247
    [TBL] [Abstract][Full Text] [Related]  

  • 27. [Study on expression of PS1 in APP-PS1 double gene stably transfected cell lines and its relation to gamma-secretase].
    Liang P; Pan YX; Zhao XM; Du HZ; Zhang JM
    Zhonghua Bing Li Xue Za Zhi; 2005 May; 34(5):297-301. PubMed ID: 16181553
    [TBL] [Abstract][Full Text] [Related]  

  • 28. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
    Asai M; Hattori C; Iwata N; Saido TC; Sasagawa N; Szabó B; Hashimoto Y; Maruyama K; Tanuma S; Kiso Y; Ishiura S
    J Neurochem; 2006 Jan; 96(2):533-40. PubMed ID: 16336629
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis.
    Rahman M; Zhang Z; Mody AA; Su DM; Das HK
    Brain Res; 2012 Apr; 1448():117-28. PubMed ID: 22353755
    [TBL] [Abstract][Full Text] [Related]  

  • 30. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
    Cupers P; Bentahir M; Craessaerts K; Orlans I; Vanderstichele H; Saftig P; De Strooper B; Annaert W
    J Cell Biol; 2001 Aug; 154(4):731-40. PubMed ID: 11502763
    [TBL] [Abstract][Full Text] [Related]  

  • 31. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
    [TBL] [Abstract][Full Text] [Related]  

  • 32. JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.
    Colombo A; Bastone A; Ploia C; Sclip A; Salmona M; Forloni G; Borsello T
    Neurobiol Dis; 2009 Mar; 33(3):518-25. PubMed ID: 19166938
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons.
    Maesako M; Houser MCQ; Turchyna Y; Wolfe MS; Berezovska O
    J Neurosci; 2022 Jan; 42(1):145-154. PubMed ID: 34810230
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines.
    Kim BM; Hong SH
    Apoptosis; 2011 Feb; 16(2):184-97. PubMed ID: 21107704
    [TBL] [Abstract][Full Text] [Related]  

  • 36. p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity.
    Dunys J; Kawarai T; Sevalle J; Dolcini V; George-Hyslop PS; Da Costa CA; Checler F
    J Biol Chem; 2007 Apr; 282(14):10516-25. PubMed ID: 17276981
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway.
    Marques CA; Keil U; Bonert A; Steiner B; Haass C; Muller WE; Eckert A
    J Biol Chem; 2003 Jul; 278(30):28294-302. PubMed ID: 12730216
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L; Gan L; Yu GQ; Essrich C; Mucke L
    J Neurochem; 2004 Dec; 91(6):1260-74. PubMed ID: 15584903
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.
    Boo JH; Sohn JH; Kim JE; Song H; Mook-Jung I
    Biochem Biophys Res Commun; 2008 Aug; 372(4):913-7. PubMed ID: 18538664
    [TBL] [Abstract][Full Text] [Related]  

  • 40. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters.
    Lin HC; Hsieh HM; Chen YH; Hu ML
    Neurotoxicology; 2009 Jul; 30(4):622-7. PubMed ID: 19635394
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.