BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 20149240)

  • 21. Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma.
    Sibbesen NA; Kopp KL; Litvinov IV; Jønson L; Willerslev-Olsen A; Fredholm S; Petersen DL; Nastasi C; Krejsgaard T; Lindahl LM; Gniadecki R; Mongan NP; Sasseville D; Wasik MA; Iversen L; Bonefeld CM; Geisler C; Woetmann A; Odum N
    Oncotarget; 2015 Aug; 6(24):20555-69. PubMed ID: 26244872
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia.
    Liao Z; Gu L; Vergalli J; Mariani SA; De Dominici M; Lokareddy RK; Dagvadorj A; Purushottamachar P; McCue PA; Trabulsi E; Lallas CD; Gupta S; Ellsworth E; Blackmon S; Ertel A; Fortina P; Leiby B; Xia G; Rui H; Hoang DT; Gomella LG; Cingolani G; Njar V; Pattabiraman N; Calabretta B; Nevalainen MT
    Mol Cancer Ther; 2015 Aug; 14(8):1777-93. PubMed ID: 26026053
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.
    Goedken ER; Argiriadi MA; Banach DL; Fiamengo BA; Foley SE; Frank KE; George JS; Harris CM; Hobson AD; Ihle DC; Marcotte D; Merta PJ; Michalak ME; Murdock SE; Tomlinson MJ; Voss JW
    J Biol Chem; 2015 Feb; 290(8):4573-4589. PubMed ID: 25552479
    [TBL] [Abstract][Full Text] [Related]  

  • 24. A receptor-independent, cell-based JAK activation assay for screening for JAK3-specific inhibitors.
    Oh K; Joo KM; Jung YS; Lee J; Kang H; Lee HY; Lee DS
    J Immunol Methods; 2010 Mar; 354(1-2):45-52. PubMed ID: 20138049
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.
    Zhu MH; Berry JA; Russell SM; Leonard WJ
    J Biol Chem; 1998 Apr; 273(17):10719-25. PubMed ID: 9553136
    [TBL] [Abstract][Full Text] [Related]  

  • 26. BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
    Nakayama J; Yamamoto M; Hayashi K; Satoh H; Bundo K; Kubo M; Goitsuka R; Farrar MA; Kitamura D
    Blood; 2009 Feb; 113(7):1483-92. PubMed ID: 19047679
    [TBL] [Abstract][Full Text] [Related]  

  • 27. JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice.
    Chang BY; Zhao F; He X; Ren H; Braselmann S; Taylor V; Wicks J; Payan DG; Grossbard EB; Pine PR; Bullard DC
    J Immunol; 2009 Aug; 183(3):2183-92. PubMed ID: 19596999
    [TBL] [Abstract][Full Text] [Related]  

  • 28. JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.
    Bouchekioua A; Scourzic L; de Wever O; Zhang Y; Cervera P; Aline-Fardin A; Mercher T; Gaulard P; Nyga R; Jeziorowska D; Douay L; Vainchenker W; Louache F; Gespach C; Solary E; Coppo P
    Leukemia; 2014 Feb; 28(2):338-48. PubMed ID: 23689514
    [TBL] [Abstract][Full Text] [Related]  

  • 29. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.
    Saharinen P; Silvennoinen O
    J Biol Chem; 2002 Dec; 277(49):47954-63. PubMed ID: 12351625
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3.
    Cortes JR; Perez-G M; Rivas MD; Zamorano J
    J Immunol; 2007 Sep; 179(6):3881-7. PubMed ID: 17785825
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Design, synthesis and structure-activity relationship studies of pyrido[2,3-d]pyrimidin-7-ones as potent Janus Kinase 3 (JAK3) covalent inhibitors.
    Su W; Chen Z; Liu M; He R; Liu C; Li R; Gao M; Zheng M; Tu Z; Zhang Z; Xu T
    Bioorg Med Chem Lett; 2022 May; 64():128680. PubMed ID: 35306167
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation.
    Liu KD; Gaffen SL; Goldsmith MA; Greene WC
    Curr Biol; 1997 Nov; 7(11):817-26. PubMed ID: 9382798
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells.
    Lin Q; Lai R; Chirieac LR; Li C; Thomazy VA; Grammatikakis I; Rassidakis GZ; Zhang W; Fujio Y; Kunisada K; Hamilton SR; Amin HM
    Am J Pathol; 2005 Oct; 167(4):969-80. PubMed ID: 16192633
    [TBL] [Abstract][Full Text] [Related]  

  • 34. STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells.
    Nagy ZS; LeBaron MJ; Ross JA; Mitra A; Rui H; Kirken RA
    Mol Cancer; 2009 Aug; 8():67. PubMed ID: 19709433
    [TBL] [Abstract][Full Text] [Related]  

  • 35. A novel indole-3-propanamide exerts its immunosuppressive activity by inhibiting JAK3 in T cells.
    Carbonnelle D; Duflos M; Marchand P; Chauvet C; Petit JY; Lang F
    J Pharmacol Exp Ther; 2009 Nov; 331(2):710-6. PubMed ID: 19710367
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling.
    Zhu F; Dai C; Fu Y; Loo JF; Xia D; Gao SP; Ma Z; Chen Z
    Oncotarget; 2016 Feb; 7(8):9462-76. PubMed ID: 26843613
    [TBL] [Abstract][Full Text] [Related]  

  • 37. JAK3 inhibitors based on thieno[3,2-d]pyrimidine scaffold: design, synthesis and bioactivity evaluation for the treatment of B-cell lymphoma.
    Chi F; Chen L; Wang C; Li L; Sun X; Xu Y; Ma T; Liu K; Ma X; Shu X
    Bioorg Chem; 2020 Jan; 95():103542. PubMed ID: 31918398
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Oncogenic activation of JAK3-STAT signaling confers clinical sensitivity to PRN371, a novel selective and potent JAK3 inhibitor, in natural killer/T-cell lymphoma.
    Nairismägi M-; Gerritsen ME; Li ZM; Wijaya GC; Chia BKH; Laurensia Y; Lim JQ; Yeoh KW; Yao XS; Pang WL; Bisconte A; Hill RJ; Bradshaw JM; Huang D; Song TLL; Ng CCY; Rajasegaran V; Tang T; Tang QQ; Xia XJ; Kang TB; Teh BT; Lim ST; Ong CK; Tan J
    Leukemia; 2018 May; 32(5):1147-1156. PubMed ID: 29434279
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.
    Thoma G; Nuninger F; Falchetto R; Hermes E; Tavares GA; Vangrevelinghe E; Zerwes HG
    J Med Chem; 2011 Jan; 54(1):284-8. PubMed ID: 21155605
    [TBL] [Abstract][Full Text] [Related]  

  • 40. JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.
    Degryse S; de Bock CE; Cox L; Demeyer S; Gielen O; Mentens N; Jacobs K; Geerdens E; Gianfelici V; Hulselmans G; Fiers M; Aerts S; Meijerink JP; Tousseyn T; Cools J
    Blood; 2014 Nov; 124(20):3092-100. PubMed ID: 25193870
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 12.