BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 20150513)

  • 1. Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization.
    Kamerlin SC; Sharma PK; Chu ZT; Warshel A
    Proc Natl Acad Sci U S A; 2010 Mar; 107(9):4075-80. PubMed ID: 20150513
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Electrostatic contributions to binding of transition state analogues can be very different from the corresponding contributions to catalysis: phenolates binding to the oxyanion hole of ketosteroid isomerase.
    Warshel A; Sharma PK; Chu ZT; Aqvist J
    Biochemistry; 2007 Feb; 46(6):1466-76. PubMed ID: 17279612
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A Preorganized Electric Field Leads to Minimal Geometrical Reorientation in the Catalytic Reaction of Ketosteroid Isomerase.
    Wu Y; Fried SD; Boxer SG
    J Am Chem Soc; 2020 Jun; 142(22):9993-9998. PubMed ID: 32378409
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole.
    Kraut DA; Sigala PA; Pybus B; Liu CW; Ringe D; Petsko GA; Herschlag D
    PLoS Biol; 2006 Apr; 4(4):e99. PubMed ID: 16602823
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site.
    Natarajan A; Schwans JP; Herschlag D
    J Am Chem Soc; 2014 May; 136(21):7643-54. PubMed ID: 24787954
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A Critical Test of the Electrostatic Contribution to Catalysis with Noncanonical Amino Acids in Ketosteroid Isomerase.
    Wu Y; Boxer SG
    J Am Chem Soc; 2016 Sep; 138(36):11890-5. PubMed ID: 27545569
    [TBL] [Abstract][Full Text] [Related]  

  • 7. QM/MM modelling of ketosteroid isomerase reactivity indicates that active site closure is integral to catalysis.
    van der Kamp MW; Chaudret R; Mulholland AJ
    FEBS J; 2013 Jul; 280(13):3120-31. PubMed ID: 23356661
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Contribution of a low-barrier hydrogen bond to catalysis is not significant in ketosteroid isomerase.
    Jang DS; Choi G; Cha HJ; Shin S; Hong BH; Lee HJ; Lee HC; Choi KY
    Mol Cells; 2015 May; 38(5):409-15. PubMed ID: 25947291
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Extreme electric fields power catalysis in the active site of ketosteroid isomerase.
    Fried SD; Bagchi S; Boxer SG
    Science; 2014 Dec; 346(6216):1510-4. PubMed ID: 25525245
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase.
    Schwans JP; Kraut DA; Herschlag D
    Proc Natl Acad Sci U S A; 2009 Aug; 106(34):14271-5. PubMed ID: 19706511
    [TBL] [Abstract][Full Text] [Related]  

  • 11. BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".
    Natarajan A; Yabukarski F; Lamba V; Schwans JP; Sunden F; Herschlag D
    Science; 2015 Aug; 349(6251):936. PubMed ID: 26315426
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Charge Density in Enzyme Active Site as a Descriptor of Electrostatic Preorganization.
    Fuller J; Wilson TR; Eberhart ME; Alexandrova AN
    J Chem Inf Model; 2019 May; 59(5):2367-2373. PubMed ID: 30793899
    [TBL] [Abstract][Full Text] [Related]  

  • 13. BIOPHYSICS. Response to Comments on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".
    Fried SD; Boxer SG
    Science; 2015 Aug; 349(6251):936. PubMed ID: 26315428
    [TBL] [Abstract][Full Text] [Related]  

  • 14. BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".
    Chen D; Savidge T
    Science; 2015 Aug; 349(6251):936. PubMed ID: 26315427
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Misunderstanding the preorganization concept can lead to confusions about the origin of enzyme catalysis.
    Jindal G; Warshel A
    Proteins; 2017 Dec; 85(12):2157-2161. PubMed ID: 28905418
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion hole.
    Kraut DA; Sigala PA; Fenn TD; Herschlag D
    Proc Natl Acad Sci U S A; 2010 Feb; 107(5):1960-5. PubMed ID: 20080683
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mutational analysis of the three cysteines and active-site aspartic acid 103 of ketosteroid isomerase from Pseudomonas putida biotype B.
    Kim SW; Joo S; Choi G; Cho HS; Oh BH; Choi KY
    J Bacteriol; 1997 Dec; 179(24):7742-7. PubMed ID: 9401033
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Electric Fields and Enzyme Catalysis.
    Fried SD; Boxer SG
    Annu Rev Biochem; 2017 Jun; 86():387-415. PubMed ID: 28375745
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Role of conserved Met112 residue in the catalytic activity and stability of ketosteroid isomerase.
    Cha HJ; Jang do S; Jeong JH; Hong BH; Yun YS; Shin EJ; Choi KY
    Biochim Biophys Acta; 2016 Oct; 1864(10):1322-7. PubMed ID: 27375051
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Proton affinity of the oxyanion hole in the active site of ketosteroid isomerase.
    Childs W; Boxer SG
    Biochemistry; 2010 Mar; 49(12):2725-31. PubMed ID: 20143849
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.