BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

531 related articles for article (PubMed ID: 20157537)

  • 21. Different combinations of genetic/epigenetic alterations inactivate the p53 and pRb pathways in invasive human bladder cancers.
    Sarkar S; Jülicher KP; Burger MS; Della Valle V; Larsen CJ; Yeager TR; Grossman TB; Nickells RW; Protzel C; Jarrard DF; Reznikoff CA
    Cancer Res; 2000 Jul; 60(14):3862-71. PubMed ID: 10919661
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts.
    Stein GH; Drullinger LF; Soulard A; Dulić V
    Mol Cell Biol; 1999 Mar; 19(3):2109-17. PubMed ID: 10022898
    [TBL] [Abstract][Full Text] [Related]  

  • 23. p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.
    Al-Khalaf HH; Aboussekhra A
    PLoS One; 2013; 8(7):e70133. PubMed ID: 23894605
    [TBL] [Abstract][Full Text] [Related]  

  • 24. 1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling.
    Chen L; Yang R; Qiao W; Zhang W; Chen J; Mao L; Goltzman D; Miao D
    Aging Cell; 2019 Jun; 18(3):e12951. PubMed ID: 30907059
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a).
    Mitra J; Dai CY; Somasundaram K; El-Deiry WS; Satyamoorthy K; Herlyn M; Enders GH
    Mol Cell Biol; 1999 May; 19(5):3916-28. PubMed ID: 10207115
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes.
    Haddad MM; Xu W; Schwahn DJ; Liao F; Medrano EE
    Exp Cell Res; 1999 Dec; 253(2):561-72. PubMed ID: 10585280
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest in cancer.
    Zarneshan SN; Fakhri S; Bachtel G; Bishayee A
    Adv Protein Chem Struct Biol; 2023; 135():1-19. PubMed ID: 37061329
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Two mechanisms underlying the loss of p16(Ink4a) function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence.
    Wu X; Jia S; Zhang X; Si X; Tang W; Luo Y
    Mech Ageing Dev; 2012 Aug; 133(8):549-55. PubMed ID: 22813853
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.
    Zou X; Ray D; Aziyu A; Christov K; Boiko AD; Gudkov AV; Kiyokawa H
    Genes Dev; 2002 Nov; 16(22):2923-34. PubMed ID: 12435633
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.
    Davis T; Singhrao SK; Wyllie FS; Haughton MF; Smith PJ; Wiltshire M; Wynford-Thomas D; Jones CJ; Faragher RG; Kipling D
    J Cell Sci; 2003 Apr; 116(Pt 7):1349-57. PubMed ID: 12615976
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.
    Douville JM; Cheung DY; Herbert KL; Moffatt T; Wigle JT
    PLoS One; 2011; 6(12):e29099. PubMed ID: 22206000
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Single-cell analysis of p16(INK4a) and p21(WAF1) expression suggests distinct mechanisms of senescence in normal human and Li-Fraumeni Syndrome fibroblasts.
    Mirzayans R; Andrais B; Scott A; Paterson MC; Murray D
    J Cell Physiol; 2010 Apr; 223(1):57-67. PubMed ID: 20039273
    [TBL] [Abstract][Full Text] [Related]  

  • 33. C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells.
    Zhuang D; Mannava S; Grachtchouk V; Tang WH; Patil S; Wawrzyniak JA; Berman AE; Giordano TJ; Prochownik EV; Soengas MS; Nikiforov MA
    Oncogene; 2008 Nov; 27(52):6623-34. PubMed ID: 18679422
    [TBL] [Abstract][Full Text] [Related]  

  • 34. P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells.
    Oruetxebarria I; Venturini F; Kekarainen T; Houweling A; Zuijderduijn LM; Mohd-Sarip A; Vries RG; Hoeben RC; Verrijzer CP
    J Biol Chem; 2004 Jan; 279(5):3807-16. PubMed ID: 14604992
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence.
    Luo H; Yount C; Lang H; Yang A; Riemer EC; Lyons K; Vanek KN; Silvestri GA; Schulte BA; Wang GY
    Lung Cancer; 2013 Aug; 81(2):167-73. PubMed ID: 23683497
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.
    Morris M; Hepburn P; Wynford-Thomas D
    Oncogene; 2002 Jun; 21(27):4277-88. PubMed ID: 12082615
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway.
    He L; Chen Y; Feng J; Sun W; Li S; Ou M; Tang L
    Int J Biochem Cell Biol; 2017 Sep; 90():29-37. PubMed ID: 28716547
    [TBL] [Abstract][Full Text] [Related]  

  • 38. AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation.
    Jackstadt R; Jung P; Hermeking H
    Cell Death Dis; 2013 Aug; 4(8):e775. PubMed ID: 23949224
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53.
    Chen J; Huang X; Halicka D; Brodsky S; Avram A; Eskander J; Bloomgarden NA; Darzynkiewicz Z; Goligorsky MS
    Am J Physiol Heart Circ Physiol; 2006 Apr; 290(4):H1575-86. PubMed ID: 16243918
    [TBL] [Abstract][Full Text] [Related]  

  • 40. p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.
    Sviderskaya EV; Gray-Schopfer VC; Hill SP; Smit NP; Evans-Whipp TJ; Bond J; Hill L; Bataille V; Peters G; Kipling D; Wynford-Thomas D; Bennett DC
    J Natl Cancer Inst; 2003 May; 95(10):723-32. PubMed ID: 12759390
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 27.