BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

126 related articles for article (PubMed ID: 20158184)

  • 1. Synthesis, in vitro and in vivo biological evaluation, docking studies, and structure--activity relationship (SAR) discussion of dipeptidyl boronic acid proteasome inhibitors composed of beta-amino acids.
    Zhu Y; Zhu X; Wu G; Ma Y; Li Y; Zhao X; Yuan Y; Yang J; Yu S; Shao F; Li R; Ke Y; Lu A; Liu Z; Zhang L
    J Med Chem; 2010 Mar; 53(5):1990-9. PubMed ID: 20158184
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, in vitro and in vivo biological evaluation, and comprehensive understanding of structure-activity relationships of dipeptidyl boronic acid proteasome inhibitors constructed from β-amino acids.
    Zhu Y; Wu G; Zhu X; Ma Y; Zhao X; Li Y; Yuan Y; Yang J; Yu S; Shao F; Lei M
    J Med Chem; 2010 Dec; 53(24):8619-26. PubMed ID: 21077681
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis, biological evaluation, and structure-activity relationship (SAR) discussion of dipeptidyl boronate proteasome inhibitors, part I: comprehensive understanding of the SAR of alpha-amino acid boronates.
    Zhu Y; Zhao X; Zhu X; Wu G; Li Y; Ma Y; Yuan Y; Yang J; Hu Y; Ai L; Gao Q
    J Med Chem; 2009 Jul; 52(14):4192-9. PubMed ID: 19537716
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and biological evaluation of tripeptide boronic acid proteasome inhibitors.
    Zhu Y; Yao S; Xu B; Ge Z; Cui J; Cheng T; Li R
    Bioorg Med Chem; 2009 Oct; 17(19):6851-61. PubMed ID: 19747832
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of boronic acid derivatives of tyropeptin: proteasome inhibitors.
    Watanabe T; Momose I; Abe M; Abe H; Sawa R; Umezawa Y; Ikeda D; Takahashi Y; Akamatsu Y
    Bioorg Med Chem Lett; 2009 Apr; 19(8):2343-5. PubMed ID: 19307118
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites.
    Pekol T; Daniels JS; Labutti J; Parsons I; Nix D; Baronas E; Hsieh F; Gan LS; Miwa G
    Drug Metab Dispos; 2005 Jun; 33(6):771-7. PubMed ID: 15764713
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed from αα- and αβ-amino acids.
    Shi J; Lei M; Wu W; Feng H; Wang J; Chen S; Zhu Y; Hu S; Liu Z; Jiang C
    Bioorg Med Chem Lett; 2016 Apr; 26(8):1958-62. PubMed ID: 26965867
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of a potent and rapidly reversible inhibitor of the 20S-proteasome.
    Purandare AV; Wan H; Laing N; Benbatoul K; Vaccaro W; Poss MA
    Bioorg Med Chem Lett; 2004 Sep; 14(18):4701-4. PubMed ID: 15324891
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacophore modeling, docking studies, and synthesis of novel dipeptide proteasome inhibitors containing boron atoms.
    Lei M; Zhao X; Wang Z; Zhu Y
    J Chem Inf Model; 2009 Sep; 49(9):2092-100. PubMed ID: 19691298
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer.
    Papandreou CN; Daliani DD; Nix D; Yang H; Madden T; Wang X; Pien CS; Millikan RE; Tu SM; Pagliaro L; Kim J; Adams J; Elliott P; Esseltine D; Petrusich A; Dieringer P; Perez C; Logothetis CJ
    J Clin Oncol; 2004 Jun; 22(11):2108-21. PubMed ID: 15169797
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype.
    Colado E; Alvarez-Fernández S; Maiso P; Martín-Sánchez J; Vidriales MB; Garayoa M; Ocio EM; Montero JC; Pandiella A; San Miguel JF
    Haematologica; 2008 Jan; 93(1):57-66. PubMed ID: 18166786
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Proteasome inhibitors for cancer therapy.
    Iqbal M; Messina McLaughlin PA; Dunn D; Mallya S; Husten J; Ator MA; Chatterjee S
    Bioorg Med Chem; 2012 Apr; 20(7):2362-8. PubMed ID: 22377673
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Chemical and biological evaluation of dipeptidyl boronic acid proteasome inhibitors for use in prodrugs and pro-soft drugs targeting solid tumors.
    Milo LJ; Lai JH; Wu W; Liu Y; Maw H; Li Y; Jin Z; Shu Y; Poplawski SE; Wu Y; Sanford DG; Sudmeier JL; Bachovchin WW
    J Med Chem; 2011 Jul; 54(13):4365-77. PubMed ID: 21634429
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-activity relationship of boronic acid derivatives of tyropeptin: proteasome inhibitors.
    Watanabe T; Abe H; Momose I; Takahashi Y; Ikeda D; Akamatsu Y
    Bioorg Med Chem Lett; 2010 Oct; 20(19):5839-42. PubMed ID: 20727746
    [TBL] [Abstract][Full Text] [Related]  

  • 15. BCL-2 family regulation by the 20S proteasome inhibitor bortezomib.
    Fennell DA; Chacko A; Mutti L
    Oncogene; 2008 Feb; 27(9):1189-97. PubMed ID: 17828309
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes.
    Lu C; Gallegos R; Li P; Xia CQ; Pusalkar S; Uttamsingh V; Nix D; Miwa GT; Gan LS
    Drug Metab Dispos; 2006 Apr; 34(4):702-8. PubMed ID: 16443666
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma.
    Heider U; von Metzler I; Kaiser M; Rosche M; Sterz J; Rötzer S; Rademacher J; Jakob C; Fleissner C; Kuckelkorn U; Kloetzel PM; Sezer O
    Eur J Haematol; 2008 Feb; 80(2):133-42. PubMed ID: 18005386
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Oxidative deboronation of the peptide boronic acid proteasome inhibitor bortezomib: contributions from reactive oxygen species in this novel cytochrome P450 reaction.
    Labutti J; Parsons I; Huang R; Miwa G; Gan LS; Daniels JS
    Chem Res Toxicol; 2006 Apr; 19(4):539-46. PubMed ID: 16608165
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Amino acid starvation sensitizes cancer cells to proteasome inhibition.
    Mizrachy-Schwartz S; Cohen N; Klein S; Kravchenko-Balasha N; Levitzki A
    IUBMB Life; 2010 Oct; 62(10):757-63. PubMed ID: 20931634
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Development of novel selective peptidomimetics containing a boronic acid moiety, targeting the 20S proteasome as anticancer agents.
    Scarbaci K; Troiano V; Ettari R; Pinto A; Micale N; Di Giovanni C; Cerchia C; Schirmeister T; Novellino E; Lavecchia A; Zappalà M; Grasso S
    ChemMedChem; 2014 Aug; 9(8):1801-16. PubMed ID: 24891205
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.