BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

170 related articles for article (PubMed ID: 20178321)

  • 1. Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening.
    Liu X; Xie H; Luo C; Tong L; Wang Y; Peng T; Ding J; Jiang H; Li H
    J Med Chem; 2010 Mar; 53(6):2661-5. PubMed ID: 20178321
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase.
    Patnaik S; Stevens KL; Gerding R; Deanda F; Shotwell JB; Tang J; Hamajima T; Nakamura H; Leesnitzer MA; Hassell AM; Shewchuck LM; Kumar R; Lei H; Chamberlain SD
    Bioorg Med Chem Lett; 2009 Jun; 19(11):3136-40. PubMed ID: 19394223
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
    Wittman MD; Carboni JM; Yang Z; Lee FY; Antman M; Attar R; Balimane P; Chang C; Chen C; Discenza L; Frennesson D; Gottardis MM; Greer A; Hurlburt W; Johnson W; Langley DR; Li A; Li J; Liu P; Mastalerz H; Mathur A; Menard K; Patel K; Sack J; Sang X; Saulnier M; Smith D; Stefanski K; Trainor G; Velaparthi U; Zhang G; Zimmermann K; Vyas DM
    J Med Chem; 2009 Dec; 52(23):7360-3. PubMed ID: 19778024
    [TBL] [Abstract][Full Text] [Related]  

  • 4. ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents.
    Steiner L; Blum G; Friedmann Y; Levitzki A
    Eur J Pharmacol; 2007 May; 562(1-2):1-11. PubMed ID: 17376430
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
    Miller LM; Mayer SC; Berger DM; Boschelli DH; Boschelli F; Di L; Du X; Dutia M; Floyd MB; Johnson M; Kenny CH; Krishnamurthy G; Moy F; Petusky S; Tkach D; Torres N; Wu B; Xu W
    Bioorg Med Chem Lett; 2009 Jan; 19(1):62-6. PubMed ID: 19041240
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
    Mayer SC; Banker AL; Boschelli F; Di L; Johnson M; Kenny CH; Krishnamurthy G; Kutterer K; Moy F; Petusky S; Ravi M; Tkach D; Tsou HR; Xu W
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3641-5. PubMed ID: 18501599
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biochemical and structural characterization of a novel class of inhibitors of the type 1 insulin-like growth factor and insulin receptor kinases.
    Bell IM; Stirdivant SM; Ahern J; Culberson JC; Darke PL; Dinsmore CJ; Drakas RA; Gallicchio SN; Graham SL; Heimbrook DC; Hall DL; Hua J; Kett NR; Kim AS; Kornienko M; Kuo LC; Munshi SK; Quigley AG; Reid JC; Trotter BW; Waxman LH; Williams TM; Zartman CB
    Biochemistry; 2005 Jul; 44(27):9430-40. PubMed ID: 15996097
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).
    Velaparthi U; Wittman M; Liu P; Stoffan K; Zimmermann K; Sang X; Carboni J; Li A; Attar R; Gottardis M; Greer A; Chang CY; Jacobsen BL; Sack JS; Sun Y; Langley DR; Balasubramanian B; Vyas D
    Bioorg Med Chem Lett; 2007 Apr; 17(8):2317-21. PubMed ID: 17317169
    [TBL] [Abstract][Full Text] [Related]  

  • 9. SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.
    Zimmermann K; Wittman MD; Saulnier MG; Velaparthi U; Sang X; Frennesson DB; Struzynski C; Seitz SP; He L; Carboni JM; Li A; Greer AF; Gottardis M; Attar RM; Yang Z; Balimane P; Discenza LN; Lee FY; Sinz M; Kim S; Vyas D
    Bioorg Med Chem Lett; 2010 Mar; 20(5):1744-8. PubMed ID: 20153189
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Screening for small molecule inhibitors of insulin-like growth factor receptor (IGF-1R) kinase: comparison of homogeneous time-resolved fluorescence and 33P-ATP plate assay formats.
    Wang Y; Malkowski M; Hailey J; Turek-Etienne T; Tripodi T; Pachter JA
    J Exp Ther Oncol; 2004 Jul; 4(2):111-9. PubMed ID: 15500006
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.
    Chamberlain SD; Wilson JW; Deanda F; Patnaik S; Redman AM; Yang B; Shewchuk L; Sabbatini P; Leesnitzer MA; Groy A; Atkins C; Gerding R; Hassell AM; Lei H; Mook RA; Moorthy G; Rowand JL; Stevens KL; Kumar R; Shotwell JB
    Bioorg Med Chem Lett; 2009 Jan; 19(2):469-73. PubMed ID: 19056263
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase.
    Ducray R; Simpson I; Jung FH; Nissink JW; Kenny PW; Fitzek M; Walker GE; Ward LT; Hudson K
    Bioorg Med Chem Lett; 2011 Aug; 21(16):4698-701. PubMed ID: 21775140
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
    Emmitte KA; Wilson BJ; Baum EW; Emerson HK; Kuntz KW; Nailor KE; Salovich JM; Smith SC; Cheung M; Gerding RM; Stevens KL; Uehling DE; Mook RA; Moorthy GS; Dickerson SH; Hassell AM; Leesnitzer MA; Shewchuk LM; Groy A; Rowand JL; Anderson K; Atkins CL; Yang J; Sabbatini P; Kumar R
    Bioorg Med Chem Lett; 2009 Feb; 19(3):1004-8. PubMed ID: 19101143
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: optimization of the aniline.
    Ducray R; Jones CD; Jung FH; Simpson I; Curwen J; Pass M
    Bioorg Med Chem Lett; 2011 Aug; 21(16):4702-4. PubMed ID: 21764307
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
    Buchanan JL; Newcomb JR; Carney DP; Chaffee SC; Chai L; Cupples R; Epstein LF; Gallant P; Gu Y; Harmange JC; Hodge K; Houk BE; Huang X; Jona J; Joseph S; Jun HT; Kumar R; Li C; Lu J; Menges T; Morrison MJ; Novak PM; van der Plas S; Radinsky R; Rose PE; Sawant S; Sun JR; Surapaneni S; Turci SM; Xu K; Yanez E; Zhao H; Zhu X
    Bioorg Med Chem Lett; 2011 Apr; 21(8):2394-9. PubMed ID: 21414779
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor.
    Wood ER; Shewchuk L; Hassel A; Nichols J; Truesdale AT; Smith D; Carter HL; Weaver K; Barrett G; Leesnitzer T; Alvarez E; Bardera AI; Alamillo A; Cantizani J; Martin J; Smith GK; Jensen DE; Xie H; Mook R; Kumar R; Kuntz K
    Biochem Pharmacol; 2009 Dec; 78(12):1438-47. PubMed ID: 19665448
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.
    Dakin LA; Block MH; Chen H; Code E; Dowling JE; Feng X; Ferguson AD; Green I; Hird AW; Howard T; Keeton EK; Lamb ML; Lyne PD; Pollard H; Read J; Wu AJ; Zhang T; Zheng X
    Bioorg Med Chem Lett; 2012 Jul; 22(14):4599-604. PubMed ID: 22727640
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Model for the complex between the insulin-like growth factor I and its receptor: towards designing antagonists for the IGF-1 receptor.
    Epa VC; Ward CW
    Protein Eng Des Sel; 2006 Aug; 19(8):377-84. PubMed ID: 16772308
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors.
    Krug M; Erlenkamp G; Sippl W; Schächtele C; Totzke F; Hilgeroth A
    Bioorg Med Chem Lett; 2010 Dec; 20(23):6915-9. PubMed ID: 21035334
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
    Harmange JC; Weiss MM; Germain J; Polverino AJ; Borg G; Bready J; Chen D; Choquette D; Coxon A; DeMelfi T; DiPietro L; Doerr N; Estrada J; Flynn J; Graceffa RF; Harriman SP; Kaufman S; La DS; Long A; Martin MW; Neervannan S; Patel VF; Potashman M; Regal K; Roveto PM; Schrag ML; Starnes C; Tasker A; Teffera Y; Wang L; White RD; Whittington DA; Zanon R
    J Med Chem; 2008 Mar; 51(6):1649-67. PubMed ID: 18324761
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.