158 related articles for article (PubMed ID: 20183598)
1. The rationale for targeting the NAD/NADH cofactor binding site of parasitic S-adenosyl-L-homocysteine hydrolase for the design of anti-parasitic drugs.
Cai S; Li QS; Fang J; Borchardt RT; Kuczera K; Middaugh CR; Schowen RL
Nucleosides Nucleotides Nucleic Acids; 2009 May; 28(5):485-503. PubMed ID: 20183598
[TBL] [Abstract][Full Text] [Related]
2. Evaluation of NAD(H) analogues as selective inhibitors for Trypanosoma cruzi S-adenosylhomocysteine hydrolase.
Li QS; Cai S; Fang J; Borchardt RT; Kuczera K; Middaugh CR; Schowen RL
Nucleosides Nucleotides Nucleic Acids; 2009 May; 28(5):473-84. PubMed ID: 20183597
[TBL] [Abstract][Full Text] [Related]
3. Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 1. Basic features of the association and dissociation processes.
Li QS; Cai S; Borchardt RT; Fang J; Kuczera K; Middaugh CR; Schowen RL
Biochemistry; 2007 May; 46(19):5798-809. PubMed ID: 17447732
[TBL] [Abstract][Full Text] [Related]
4. Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability.
Li QS; Cai S; Fang J; Borchardt RT; Kuczera K; Middaugh CR; Schowen RL
Biochemistry; 2008 Apr; 47(17):4983-91. PubMed ID: 18393535
[TBL] [Abstract][Full Text] [Related]
5. The antiviral drug ribavirin is a selective inhibitor of S-adenosyl-L-homocysteine hydrolase from Trypanosoma cruzi.
Cai S; Li QS; Borchardt RT; Kuczera K; Schowen RL
Bioorg Med Chem; 2007 Dec; 15(23):7281-7. PubMed ID: 17845853
[TBL] [Abstract][Full Text] [Related]
6. Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 3. Role of lysyl and tyrosyl residues of the C-terminal extension.
Cai S; Fang J; Li QS; Borchardt RT; Kuczera K; Middaugh CR; Schowen RL
Biochemistry; 2010 Sep; 49(38):8434-41. PubMed ID: 20687591
[TBL] [Abstract][Full Text] [Related]
7. Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Reddy MC; Kuppan G; Shetty ND; Owen JL; Ioerger TR; Sacchettini JC
Protein Sci; 2008 Dec; 17(12):2134-44. PubMed ID: 18815415
[TBL] [Abstract][Full Text] [Related]
8. Copper ions inhibit S-adenosylhomocysteine hydrolase by causing dissociation of NAD+ cofactor.
Li M; Li Y; Chen J; Wei W; Pan X; Liu J; Liu Q; Leu W; Zhang L; Yang X; Lu J; Wang K
Biochemistry; 2007 Oct; 46(41):11451-8. PubMed ID: 17892301
[TBL] [Abstract][Full Text] [Related]
9. Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacterium Thermotoga maritima.
Zheng Y; Chen CC; Ko TP; Xiao X; Yang Y; Huang CH; Qian G; Shao W; Guo RT
J Struct Biol; 2015 May; 190(2):135-42. PubMed ID: 25791616
[TBL] [Abstract][Full Text] [Related]
10. Domain motions and the open-to-closed conformational transition of an enzyme: a normal mode analysis of S-adenosyl-L-homocysteine hydrolase.
Wang M; Borchardt RT; Schowen RL; Kuczera K
Biochemistry; 2005 May; 44(19):7228-39. PubMed ID: 15882061
[TBL] [Abstract][Full Text] [Related]
11. An enzyme captured in two conformational states: crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii.
Manszewski T; Singh K; Imiolczyk B; Jaskolski M
Acta Crystallogr D Biol Crystallogr; 2015 Dec; 71(Pt 12):2422-32. PubMed ID: 26627650
[TBL] [Abstract][Full Text] [Related]
12. Structural insights into the reaction mechanism of S-adenosyl-L-homocysteine hydrolase.
Kusakabe Y; Ishihara M; Umeda T; Kuroda D; Nakanishi M; Kitade Y; Gouda H; Nakamura KT; Tanaka N
Sci Rep; 2015 Nov; 5():16641. PubMed ID: 26573329
[TBL] [Abstract][Full Text] [Related]
13. Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi.
Freymann DM; Wenck MA; Engel JC; Feng J; Focia PJ; Eakin AE; Craig SP
Chem Biol; 2000 Dec; 7(12):957-68. PubMed ID: 11137818
[TBL] [Abstract][Full Text] [Related]
14. Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.
Wang Y; Kavran JM; Chen Z; Karukurichi KR; Leahy DJ; Cole PA
J Biol Chem; 2014 Nov; 289(45):31361-72. PubMed ID: 25248746
[TBL] [Abstract][Full Text] [Related]
15. Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum.
Tanaka N; Nakanishi M; Kusakabe Y; Shiraiwa K; Yabe S; Ito Y; Kitade Y; Nakamura KT
J Mol Biol; 2004 Oct; 343(4):1007-17. PubMed ID: 15476817
[TBL] [Abstract][Full Text] [Related]
16. Regulation of homocysteine metabolism by Mycobacterium tuberculosis S-adenosylhomocysteine hydrolase.
Singhal A; Arora G; Sajid A; Maji A; Bhat A; Virmani R; Upadhyay S; Nandicoori VK; Sengupta S; Singh Y
Sci Rep; 2013; 3():2264. PubMed ID: 23877358
[TBL] [Abstract][Full Text] [Related]
17. Molecular dynamics simulations of domain motions of substrate-free S-adenosyl- L-homocysteine hydrolase in solution.
Hu C; Fang J; Borchardt RT; Schowen RL; Kuczera K
Proteins; 2008 Apr; 71(1):131-43. PubMed ID: 17932938
[TBL] [Abstract][Full Text] [Related]
18. Structural basis for substrate recognition by a S-adenosylhomocysteine hydrolase Lpg2021 from Legionella pneumophila.
Gao Y; Xie R; Chen Y; Yang B; Wang M; Hua L; Wang X; Wang W; Wang N; Ge H; Ma J
Int J Biol Macromol; 2024 Jun; 270(Pt 1):132289. PubMed ID: 38735607
[TBL] [Abstract][Full Text] [Related]
19. Identification of novel S-adenosyl-L-homocysteine hydrolase inhibitors through homology-model-based virtual screening, synthesis, and biological evaluation.
Khare P; Gupta AK; Gajula PK; Sunkari KY; Jaiswal AK; Das S; Bajpai P; Chakraborty TK; Dube A; Saxena AK
J Chem Inf Model; 2012 Mar; 52(3):777-91. PubMed ID: 22324915
[TBL] [Abstract][Full Text] [Related]
20. Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs.
Vázquez K; Paulino M; Salas CO; Zarate-Ramos JJ; Vera B; Rivera G
Mini Rev Med Chem; 2017; 17(11):939-946. PubMed ID: 28302040
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]