104 related articles for article (PubMed ID: 20188543)
1. Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors.
Wiener DK; Lee-Dutra A; Bembenek S; Nguyen S; Thurmond RL; Sun S; Karlsson L; Grice CA; Jones TK; Edwards JP
Bioorg Med Chem Lett; 2010 Apr; 20(7):2379-82. PubMed ID: 20188543
[TBL] [Abstract][Full Text] [Related]
2. Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.
Lee-Dutra A; Wiener DK; Arienti KL; Liu J; Mani N; Ameriks MK; Axe FU; Gebauer D; Desai PJ; Nguyen S; Randal M; Thurmond RL; Sun S; Karlsson L; Edwards JP; Jones TK; Grice CA
Bioorg Med Chem Lett; 2010 Apr; 20(7):2370-4. PubMed ID: 20153648
[TBL] [Abstract][Full Text] [Related]
3. Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions.
Wiener JJ; Wickboldt AT; Wiener DK; Lee-Dutra A; Edwards JP; Karlsson L; Nguyen S; Sun S; Jones TK; Grice CA
Bioorg Med Chem Lett; 2010 Apr; 20(7):2375-8. PubMed ID: 20171097
[TBL] [Abstract][Full Text] [Related]
4. Pyrazole-based cathepsin S inhibitors with improved cellular potency.
Wei J; Pio BA; Cai H; Meduna SP; Sun S; Gu Y; Jiang W; Thurmond RL; Karlsson L; Edwards JP
Bioorg Med Chem Lett; 2007 Oct; 17(20):5525-8. PubMed ID: 17822900
[TBL] [Abstract][Full Text] [Related]
5. Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency.
Ameriks MK; Cai H; Edwards JP; Gebauer D; Gleason E; Gu Y; Karlsson L; Nguyen S; Sun S; Thurmond RL; Zhu J
Bioorg Med Chem Lett; 2009 Nov; 19(21):6135-9. PubMed ID: 19783435
[TBL] [Abstract][Full Text] [Related]
6. Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
Ameriks MK; Axe FU; Bembenek SD; Edwards JP; Gu Y; Karlsson L; Randal M; Sun S; Thurmond RL; Zhu J
Bioorg Med Chem Lett; 2009 Nov; 19(21):6131-4. PubMed ID: 19773165
[TBL] [Abstract][Full Text] [Related]
7. Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region.
Wiener JJ; Wickboldt AT; Nguyen S; Sun S; Rynberg R; Rizzolio M; Karlsson L; Edwards JP; Grice CA
Bioorg Med Chem Lett; 2013 Feb; 23(4):1070-4. PubMed ID: 23313244
[TBL] [Abstract][Full Text] [Related]
8. Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors.
Ameriks MK; Bembenek SD; Burdett MT; Choong IC; Edwards JP; Gebauer D; Gu Y; Karlsson L; Purkey HE; Staker BL; Sun S; Thurmond RL; Zhu J
Bioorg Med Chem Lett; 2010 Jul; 20(14):4060-4. PubMed ID: 20541404
[TBL] [Abstract][Full Text] [Related]
9. Keto-1,3,4-oxadiazoles as cathepsin K inhibitors.
Palmer JT; Hirschbein BL; Cheung H; McCarter J; Janc JW; Yu ZW; Wesolowski G
Bioorg Med Chem Lett; 2006 Jun; 16(11):2909-14. PubMed ID: 16546382
[TBL] [Abstract][Full Text] [Related]
10. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.
Altmann E; Aichholz R; Betschart C; Buhl T; Green J; Irie O; Teno N; Lattmann R; Tintelnot-Blomley M; Missbach M
J Med Chem; 2007 Feb; 50(4):591-4. PubMed ID: 17256925
[TBL] [Abstract][Full Text] [Related]
11. Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: effect of sulfonamides P3 substituents on potency and selectivity.
Ayesa S; Lindquist C; Agback T; Benkestock K; Classon B; Henderson I; Hewitt E; Jansson K; Kallin A; Sheppard D; Samuelsson B
Bioorg Med Chem; 2009 Feb; 17(3):1307-24. PubMed ID: 19124252
[TBL] [Abstract][Full Text] [Related]
12. Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1.
Liu H; Tully DC; Epple R; Bursulaya B; Li J; Harris JL; Williams JA; Russo R; Tumanut C; Roberts MJ; Alper PB; He Y; Karanewsky DS
Bioorg Med Chem Lett; 2005 Nov; 15(22):4979-84. PubMed ID: 16183279
[TBL] [Abstract][Full Text] [Related]
13. Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.
Gustin DJ; Sehon CA; Wei J; Cai H; Meduna SP; Khatuya H; Sun S; Gu Y; Jiang W; Thurmond RL; Karlsson L; Edwards JP
Bioorg Med Chem Lett; 2005 Mar; 15(6):1687-91. PubMed ID: 15745822
[TBL] [Abstract][Full Text] [Related]
14. Azepanone-based inhibitors of human cathepsin S: optimization of selectivity via the P2 substituent.
Kerns JK; Nie H; Bondinell W; Widdowson KL; Yamashita DS; Rahman A; Podolin PL; Carpenter DC; Jin Q; Riflade B; Dong X; Nevins N; Keller PM; Mitchell L; Tomaszek T
Bioorg Med Chem Lett; 2011 Aug; 21(15):4409-15. PubMed ID: 21733692
[TBL] [Abstract][Full Text] [Related]
15. Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
Patterson AW; Wood WJ; Hornsby M; Lesley S; Spraggon G; Ellman JA
J Med Chem; 2006 Oct; 49(21):6298-307. PubMed ID: 17034136
[TBL] [Abstract][Full Text] [Related]
16. Design of selective Cathepsin inhibitors.
Bethel PA; Gerhardt S; Jones EV; Kenny PW; Karoutchi GI; Morley AD; Oldham K; Rankine N; Augustin M; Krapp S; Simader H; Steinbacher S
Bioorg Med Chem Lett; 2009 Aug; 19(16):4622-5. PubMed ID: 19616430
[TBL] [Abstract][Full Text] [Related]
17. SAR studies of some acetophenone phenylhydrazone based pyrazole derivatives as anticathepsin agents.
Raghav N; Singh M
Bioorg Chem; 2017 Dec; 75():38-49. PubMed ID: 28915464
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers.
Tully DC; Liu H; Chatterjee AK; Alper PB; Epple R; Williams JA; Roberts MJ; Woodmansee DH; Masick BT; Tumanut C; Li J; Spraggon G; Hornsby M; Chang J; Tuntland T; Hollenbeck T; Gordon P; Harris JL; Karanewsky DS
Bioorg Med Chem Lett; 2006 Oct; 16(19):5112-7. PubMed ID: 16876402
[TBL] [Abstract][Full Text] [Related]
19. Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F.
Frizler M; Schmitz J; Schulz-Fincke AC; Gütschow M
J Med Chem; 2012 Jun; 55(12):5982-6. PubMed ID: 22686657
[TBL] [Abstract][Full Text] [Related]
20. Potent and selective ketoamide-based inhibitors of cysteine protease, cathepsin K.
Tavares FX; Deaton DN; Miller AB; Miller LR; Wright LL; Zhou HQ
J Med Chem; 2004 Oct; 47(21):5049-56. PubMed ID: 15456248
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]