203 related articles for article (PubMed ID: 20189385)
21. The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
Jagtap PG; Southan GJ; Baloglu E; Ram S; Mabley JG; Marton A; Salzman A; Szabó C
Bioorg Med Chem Lett; 2004 Jan; 14(1):81-5. PubMed ID: 14684303
[TBL] [Abstract][Full Text] [Related]
22. 3. Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia.
Pellicciari R; Camaioni E; Costantino G
Prog Med Chem; 2004; 42():125-69. PubMed ID: 15003720
[No Abstract] [Full Text] [Related]
23. Novel PARP-1 inhibitors based on a 2-propanoyl-3H-quinazolin-4-one scaffold.
Giannini G; Battistuzzi G; Vesci L; Milazzo FM; De Paolis F; Barbarino M; Guglielmi MB; Carollo V; Gallo G; Artali R; Dallavalle S
Bioorg Med Chem Lett; 2014 Jan; 24(2):462-6. PubMed ID: 24388690
[TBL] [Abstract][Full Text] [Related]
24. Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.
Jagtap PG; Baloglu E; Southan GJ; Mabley JG; Li H; Zhou J; van Duzer J; Salzman AL; Szabó C
J Med Chem; 2005 Aug; 48(16):5100-3. PubMed ID: 16078828
[TBL] [Abstract][Full Text] [Related]
25. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.
Eltze T; Boer R; Wagner T; Weinbrenner S; McDonald MC; Thiemermann C; Bürkle A; Klein T
Mol Pharmacol; 2008 Dec; 74(6):1587-98. PubMed ID: 18809672
[TBL] [Abstract][Full Text] [Related]
26. Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors.
Wang LX; Zhou XB; Xiao ML; Jiang N; Liu F; Zhou WX; Wang XK; Zheng ZB; Li S
Bioorg Med Chem Lett; 2014 Aug; 24(16):3739-43. PubMed ID: 25086680
[TBL] [Abstract][Full Text] [Related]
27. Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation.
Li H; Hu Y; Wang X; He G; Xu Y; Zhu Q
Bioorg Med Chem; 2016 Oct; 24(19):4731-4740. PubMed ID: 27561983
[TBL] [Abstract][Full Text] [Related]
28. Multi-targeted organometallic ruthenium(II)-arene anticancer complexes bearing inhibitors of poly(ADP-ribose) polymerase-1: A strategy to improve cytotoxicity.
Wang Z; Qian H; Yiu SM; Sun J; Zhu G
J Inorg Biochem; 2014 Feb; 131():47-55. PubMed ID: 24239912
[TBL] [Abstract][Full Text] [Related]
29. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Jones P; Altamura S; Boueres J; Ferrigno F; Fonsi M; Giomini C; Lamartina S; Monteagudo E; Ontoria JM; Orsale MV; Palumbi MC; Pesci S; Roscilli G; Scarpelli R; Schultz-Fademrecht C; Toniatti C; Rowley M
J Med Chem; 2009 Nov; 52(22):7170-85. PubMed ID: 19873981
[TBL] [Abstract][Full Text] [Related]
30. Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.
Lehtiö L; Jemth AS; Collins R; Loseva O; Johansson A; Markova N; Hammarström M; Flores A; Holmberg-Schiavone L; Weigelt J; Helleday T; Schüler H; Karlberg T
J Med Chem; 2009 May; 52(9):3108-11. PubMed ID: 19354255
[TBL] [Abstract][Full Text] [Related]
31. A novel and orally active poly(ADP-ribose) polymerase inhibitor, KR-33889 [2-[methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia.
Oh KS; Lee S; Yi KY; Seo HW; Koo HN; Lee BH
J Pharmacol Exp Ther; 2009 Jan; 328(1):10-8. PubMed ID: 18836068
[TBL] [Abstract][Full Text] [Related]
32. Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase.
Loh VM; Cockcroft XL; Dillon KJ; Dixon L; Drzewiecki J; Eversley PJ; Gomez S; Hoare J; Kerrigan F; Matthews IT; Menear KA; Martin NM; Newton RF; Paul J; Smith GC; Vile J; Whittle AJ
Bioorg Med Chem Lett; 2005 May; 15(9):2235-8. PubMed ID: 15837300
[TBL] [Abstract][Full Text] [Related]
33. Discovery of 2-(1-(3-(4-Chloroxyphenyl)-3-oxo- propyl)pyrrolidine-3-yl)-1
Min R; Wu W; Wang M; Tang L; Chen D; Zhao H; Zhang C; Jiang Y
Molecules; 2019 May; 24(10):. PubMed ID: 31108884
[TBL] [Abstract][Full Text] [Related]
34. Discovery and SAR study of 2-(1-propylpiperidin-4-yl)-3H-imidazo[4,5-c]pyridine-7-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) for the treatment of cancer.
Zhu Q; Wang X; Hu Y; He X; Gong G; Xu Y
Bioorg Med Chem; 2015 Oct; 23(20):6551-9. PubMed ID: 26422786
[TBL] [Abstract][Full Text] [Related]
35. Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries.
Ferraris D; Ko YS; Pahutski T; Ficco RP; Serdyuk L; Alemu C; Bradford C; Chiou T; Hoover R; Huang S; Lautar S; Liang S; Lin Q; Lu MX; Mooney M; Morgan L; Qian Y; Tran S; Williams LR; Wu QY; Zhang J; Zou Y; Kalish V
J Med Chem; 2003 Jul; 46(14):3138-51. PubMed ID: 12825952
[TBL] [Abstract][Full Text] [Related]
36. Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells.
Ferrigno F; Branca D; Kinzel O; Lillini S; Llauger Bufi L; Monteagudo E; Muraglia E; Rowley M; Schultz-Fademrecht C; Toniatti C; Torrisi C; Jones P
Bioorg Med Chem Lett; 2010 Feb; 20(3):1100-5. PubMed ID: 20022747
[TBL] [Abstract][Full Text] [Related]
37. Influence of usnic acid and its derivatives on the activity of mammalian poly(ADP-ribose)polymerase 1 and DNA polymerase β.
Zakharenko A; Sokolov D; Luzina O; Sukhanova M; Khodyreva S; Zakharova O; Salakhutdinov N; Lavrik O
Med Chem; 2012 Sep; 8(5):883-93. PubMed ID: 22741606
[TBL] [Abstract][Full Text] [Related]
38. Synthesis and structure-activity relationships of novel pyrrolocarbazole lactam analogs as potent and cell-permeable inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Wells GJ; Bihovsky R; Hudkins RL; Ator MA; Husten J
Bioorg Med Chem Lett; 2006 Mar; 16(5):1151-5. PubMed ID: 16359865
[TBL] [Abstract][Full Text] [Related]
39. Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors.
Zhu Q; Wang X; Chu Z; He G; Dong G; Xu Y
Bioorg Med Chem Lett; 2013 Apr; 23(7):1993-6. PubMed ID: 23481647
[TBL] [Abstract][Full Text] [Related]
40. Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.
Skalitzky DJ; Marakovits JT; Maegley KA; Ekker A; Yu XH; Hostomsky Z; Webber SE; Eastman BW; Almassy R; Li J; Curtin NJ; Newell DR; Calvert AH; Griffin RJ; Golding BT
J Med Chem; 2003 Jan; 46(2):210-3. PubMed ID: 12519059
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
