371 related articles for article (PubMed ID: 20198480)
1. Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.
Kraemer BC; Schuck T; Wheeler JM; Robinson LC; Trojanowski JQ; Lee VM; Schellenberg GD
Acta Neuropathol; 2010 Apr; 119(4):409-19. PubMed ID: 20198480
[TBL] [Abstract][Full Text] [Related]
2. Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS.
Ebstein SY; Yagudayeva I; Shneider NA
Cell Rep; 2019 Jan; 26(2):364-373.e4. PubMed ID: 30625319
[TBL] [Abstract][Full Text] [Related]
3. Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.
Ke YD; van Hummel A; Stevens CH; Gladbach A; Ippati S; Bi M; Lee WS; Krüger S; van der Hoven J; Volkerling A; Bongers A; Halliday G; Haass NK; Kiernan M; Delerue F; Ittner LM
Acta Neuropathol; 2015 Nov; 130(5):661-78. PubMed ID: 26437864
[TBL] [Abstract][Full Text] [Related]
4. Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
Kabashi E; Lin L; Tradewell ML; Dion PA; Bercier V; Bourgouin P; Rochefort D; Bel Hadj S; Durham HD; Vande Velde C; Rouleau GA; Drapeau P
Hum Mol Genet; 2010 Feb; 19(4):671-83. PubMed ID: 19959528
[TBL] [Abstract][Full Text] [Related]
5. Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.
Ditsworth D; Maldonado M; McAlonis-Downes M; Sun S; Seelman A; Drenner K; Arnold E; Ling SC; Pizzo D; Ravits J; Cleveland DW; Da Cruz S
Acta Neuropathol; 2017 Jun; 133(6):907-922. PubMed ID: 28357566
[TBL] [Abstract][Full Text] [Related]
6. Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Gordon D; Dafinca R; Scaber J; Alegre-Abarrategui J; Farrimond L; Scott C; Biggs D; Kent L; Oliver PL; Davies B; Ansorge O; Wade-Martins R; Talbot K
Neurobiol Dis; 2019 Jan; 121():148-162. PubMed ID: 30290270
[TBL] [Abstract][Full Text] [Related]
7. Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo.
Williamson MG; Finelli MJ; Sleigh JN; Reddington A; Gordon D; Talbot K; Davies KE; Oliver PL
Hum Mol Genet; 2019 Nov; 28(21):3584-3599. PubMed ID: 31642482
[TBL] [Abstract][Full Text] [Related]
8. Human TDP-43 and FUS selectively affect motor neuron maturation and survival in a murine cell model of ALS by non-cell-autonomous mechanisms.
Wächter N; Storch A; Hermann A
Amyotroph Lateral Scler Frontotemporal Degener; 2015; 16(7-8):431-41. PubMed ID: 26174443
[TBL] [Abstract][Full Text] [Related]
9. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.
Schmid B; Hruscha A; Hogl S; Banzhaf-Strathmann J; Strecker K; van der Zee J; Teucke M; Eimer S; Hegermann J; Kittelmann M; Kremmer E; Cruts M; Solchenberger B; Hasenkamp L; van Bebber F; Van Broeckhoven C; Edbauer D; Lichtenthaler SF; Haass C
Proc Natl Acad Sci U S A; 2013 Mar; 110(13):4986-91. PubMed ID: 23457265
[TBL] [Abstract][Full Text] [Related]
10. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43.
Koyama A; Sugai A; Kato T; Ishihara T; Shiga A; Toyoshima Y; Koyama M; Konno T; Hirokawa S; Yokoseki A; Nishizawa M; Kakita A; Takahashi H; Onodera O
Nucleic Acids Res; 2016 Jul; 44(12):5820-36. PubMed ID: 27257061
[TBL] [Abstract][Full Text] [Related]
11. A robust TDP-43 knock-in mouse model of ALS.
Huang SL; Wu LS; Lee M; Chang CW; Cheng WC; Fang YS; Chen YR; Cheng PL; Shen CJ
Acta Neuropathol Commun; 2020 Jan; 8(1):3. PubMed ID: 31964415
[TBL] [Abstract][Full Text] [Related]
12. Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution.
De Marco G; Lomartire A; Calvo A; Risso A; De Luca E; Mostert M; Mandrioli J; Caponnetto C; Borghero G; Manera U; Canosa A; Moglia C; Restagno G; Fini N; Tarella C; Giordana MT; Rinaudo MT; Chiò A
Neuropathol Appl Neurobiol; 2017 Feb; 43(2):133-153. PubMed ID: 27178390
[TBL] [Abstract][Full Text] [Related]
13. Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
Fratta P; Sivakumar P; Humphrey J; Lo K; Ricketts T; Oliveira H; Brito-Armas JM; Kalmar B; Ule A; Yu Y; Birsa N; Bodo C; Collins T; Conicella AE; Mejia Maza A; Marrero-Gagliardi A; Stewart M; Mianne J; Corrochano S; Emmett W; Codner G; Groves M; Fukumura R; Gondo Y; Lythgoe M; Pauws E; Peskett E; Stanier P; Teboul L; Hallegger M; Calvo A; Chiò A; Isaacs AM; Fawzi NL; Wang E; Housman DE; Baralle F; Greensmith L; Buratti E; Plagnol V; Fisher EM; Acevedo-Arozena A
EMBO J; 2018 Jun; 37(11):. PubMed ID: 29764981
[TBL] [Abstract][Full Text] [Related]
14. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.
Xu YF; Gendron TF; Zhang YJ; Lin WL; D'Alton S; Sheng H; Casey MC; Tong J; Knight J; Yu X; Rademakers R; Boylan K; Hutton M; McGowan E; Dickson DW; Lewis J; Petrucelli L
J Neurosci; 2010 Aug; 30(32):10851-9. PubMed ID: 20702714
[TBL] [Abstract][Full Text] [Related]
15. Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.
Marques RF; Engler JB; Küchler K; Jones RA; Lingner T; Salinas G; Gillingwater TH; Friese MA; Duncan KE
Hum Mol Genet; 2020 Sep; 29(16):2647-2661. PubMed ID: 32686835
[TBL] [Abstract][Full Text] [Related]
16. A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6/J mice.
Coughlan KS; Halang L; Woods I; Prehn JH
Dis Model Mech; 2016 Sep; 9(9):1029-37. PubMed ID: 27491077
[TBL] [Abstract][Full Text] [Related]
17. Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.
Jeon GS; Shim YM; Lee DY; Kim JS; Kang M; Ahn SH; Shin JY; Geum D; Hong YH; Sung JJ
Mol Neurobiol; 2019 Mar; 56(3):2007-2021. PubMed ID: 29982983
[TBL] [Abstract][Full Text] [Related]
18. Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation.
Sugai A; Kato T; Koyama A; Koike Y; Konno T; Ishihara T; Onodera O
Neurobiol Dis; 2019 Oct; 130():104534. PubMed ID: 31310801
[TBL] [Abstract][Full Text] [Related]
19. TDP-43 is a developmentally regulated protein essential for early embryonic development.
Sephton CF; Good SK; Atkin S; Dewey CM; Mayer P; Herz J; Yu G
J Biol Chem; 2010 Feb; 285(9):6826-34. PubMed ID: 20040602
[TBL] [Abstract][Full Text] [Related]
20. Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
Stribl C; Samara A; Trümbach D; Peis R; Neumann M; Fuchs H; Gailus-Durner V; Hrabě de Angelis M; Rathkolb B; Wolf E; Beckers J; Horsch M; Neff F; Kremmer E; Koob S; Reichert AS; Hans W; Rozman J; Klingenspor M; Aichler M; Walch AK; Becker L; Klopstock T; Glasl L; Hölter SM; Wurst W; Floss T
J Biol Chem; 2014 Apr; 289(15):10769-10784. PubMed ID: 24515116
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
