BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 20206516)

  • 1. Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.
    Mattson MN; Neitzel ML; Quincy DA; Semko CM; Garofalo AW; Keim PS; Konradi AW; Pleiss MA; Sham HL; Brigham EF; Goldbach EG; Zhang H; Sauer JM; Basi GS
    Bioorg Med Chem Lett; 2010 Apr; 20(7):2148-50. PubMed ID: 20206516
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
    Ye XM; Konradi AW; Smith J; Xu YZ; Dressen D; Garofalo AW; Marugg J; Sham HL; Truong AP; Jagodzinski J; Pleiss M; Zhang H; Goldbach E; Sauer JM; Brigham E; Bova M; Basi GS
    Bioorg Med Chem Lett; 2010 Apr; 20(7):2195-9. PubMed ID: 20207136
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
    Pu J; Kreft AF; Aschmies SH; Atchison KP; Berkowitz J; Caggiano TJ; Chlenov M; Diamantidis G; Harrison BL; Hu Y; Huryn D; Steven Jacobsen J; Jin M; Lipinski K; Lu P; Martone RL; Morris K; Sonnenberg-Reines J; Riddell DR; Sabalski J; Sun SC; Wagner E; Wang Y; Xu Z; Zhou H; Resnick L
    Bioorg Med Chem; 2009 Jul; 17(13):4708-17. PubMed ID: 19443228
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
    Mayer SC; Kreft AF; Harrison B; Abou-Gharbia M; Antane M; Aschmies S; Atchison K; Chlenov M; Cole DC; Comery T; Diamantidis G; Ellingboe J; Fan K; Galante R; Gonzales C; Ho DM; Hoke ME; Hu Y; Huryn D; Jain U; Jin M; Kremer K; Kubrak D; Lin M; Lu P; Magolda R; Martone R; Moore W; Oganesian A; Pangalos MN; Porte A; Reinhart P; Resnick L; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Wang T; Woller K; Xu Z; Zaleska MM; Zeldis J; Zhang M; Zhou H; Jacobsen JS
    J Med Chem; 2008 Dec; 51(23):7348-51. PubMed ID: 19012391
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
    Truong AP; Aubele DL; Probst GD; Neitzel ML; Semko CM; Bowers S; Dressen D; Hom RK; Konradi AW; Sham HL; Garofalo AW; Keim PS; Wu J; Dappen MS; Wong K; Goldbach E; Quinn KP; Sauer JM; Brigham EF; Wallace W; Nguyen L; Hemphill SS; Bova MP; Bard F; Yednock TA; Basi G
    Bioorg Med Chem Lett; 2009 Sep; 19(17):4920-3. PubMed ID: 19660943
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
    Ye XM; Konradi AW; Sun M; Yuan S; Aubele DL; Dappen M; Dressen D; Garofalo AW; Jagodzinski JJ; Latimer L; Probst GD; Sham HL; Wone D; Xu YZ; Ness D; Brigham E; Kwong GT; Willtis C; Tonn G; Goldbach E; Quinn KP; Zhang HH; Sauer JM; Bova M; Basi GS
    Bioorg Med Chem Lett; 2013 Feb; 23(4):996-1000. PubMed ID: 23312944
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
    Aubele DL; Truong AP; Dressen DB; Probst GD; Bowers S; Mattson MN; Semko CM; Sun M; Garofalo AW; Konradi AW; Sham HL; Zmolek W; Wong K; Goldbach E; Quinn KP; Sauer JM; Brigham EF; Wallace W; Nguyen L; Bova MP; Hemphill SS; Basi G
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5791-4. PubMed ID: 21885276
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Tetrahydroquinoline sulfonamides as gamma-secretase inhibitors.
    Asberom T; Bara TA; Clader JW; Greenlee WJ; Guzik HS; Josien HB; Li W; Parker EM; Pissarnitski DA; Song L; Zhang L; Zhao Z
    Bioorg Med Chem Lett; 2007 Jan; 17(1):205-7. PubMed ID: 17046254
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
    Cumming J; Babu S; Huang Y; Carrol C; Chen X; Favreau L; Greenlee W; Guo T; Kennedy M; Kuvelkar R; Le T; Li G; McHugh N; Orth P; Ozgur L; Parker E; Saionz K; Stamford A; Strickland C; Tadesse D; Voigt J; Zhang L; Zhang Q
    Bioorg Med Chem Lett; 2010 May; 20(9):2837-42. PubMed ID: 20347593
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease.
    Asberom T; Zhao Z; Bara TA; Clader JW; Greenlee WJ; Hyde LA; Josien HB; Li W; McPhail AT; Nomeir AA; Parker EM; Rajagopalan M; Song L; Wong GT; Zhang L; Zhang Q; Pissarnitski DA
    Bioorg Med Chem Lett; 2007 Jan; 17(2):511-6. PubMed ID: 17079141
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.
    Guo T; Gu H; Hobbs DW; Rokosz LL; Stauffer TM; Jacob B; Clader JW
    Bioorg Med Chem Lett; 2007 Jun; 17(11):3010-3. PubMed ID: 17418571
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
    Bergstrom CP; Sloan CP; Lau WY; Smith DW; Zheng M; Hansel SB; Polson CT; Corsa JA; Barten DM; Felsenstein KM; Roberts SB
    Bioorg Med Chem Lett; 2008 Jan; 18(2):464-8. PubMed ID: 18178084
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of a novel series of Notch-sparing gamma-secretase inhibitors.
    Kreft A; Harrison B; Aschmies S; Atchison K; Casebier D; Cole DC; Diamantidis G; Ellingboe J; Hauze D; Hu Y; Huryn D; Jin M; Kubrak D; Lu P; Lundquist J; Mann C; Martone R; Moore W; Oganesian A; Porte A; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Woller K; Xu Z; Zhou H; Steven Jacobsen J
    Bioorg Med Chem Lett; 2008 Jul; 18(14):4232-6. PubMed ID: 18556202
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.
    Malamas MS; Barnes K; Hui Y; Johnson M; Lovering F; Condon J; Fobare W; Solvibile W; Turner J; Hu Y; Manas ES; Fan K; Olland A; Chopra R; Bard J; Pangalos MN; Reinhart P; Robichaud AJ
    Bioorg Med Chem Lett; 2010 Apr; 20(7):2068-73. PubMed ID: 20223661
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).
    Ye XM; Konradi AW; Smith J; Aubele DL; Garofalo AW; Marugg J; Neitzel ML; Semko CM; Sham HL; Sun M; Truong AP; Wu J; Zhang H; Goldbach E; Sauer JM; Brigham EF; Bova M; Basi GS
    Bioorg Med Chem Lett; 2010 Jun; 20(12):3502-6. PubMed ID: 20529683
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design of potent inhibitors of human beta-secretase. Part 2.
    Freskos JN; Fobian YM; Benson TE; Moon JB; Bienkowski MJ; Brown DL; Emmons TL; Heintz R; Laborde A; McDonald JJ; Mischke BV; Molyneaux JM; Mullins PB; Bryan Prince D; Paddock DJ; Tomasselli AG; Winterrowd G
    Bioorg Med Chem Lett; 2007 Jan; 17(1):78-81. PubMed ID: 17049233
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
    Ghosh AK; Kumaragurubaran N; Hong L; Kulkarni SS; Xu X; Chang W; Weerasena V; Turner R; Koelsch G; Bilcer G; Tang J
    J Med Chem; 2007 May; 50(10):2399-407. PubMed ID: 17432843
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.
    Sasikumar TK; Qiang L; Burnett DA; Cole D; Xu R; Li H; Greenlee WJ; Clader J; Zhang L; Hyde L
    Bioorg Med Chem Lett; 2010 Jun; 20(12):3632-5. PubMed ID: 20493690
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
    Bergstrom CP; Sloan CP; Wang HH; Parker MF; Smith DW; Zheng M; Hansel SB; Polson CT; Barber LE; Bursuker I; Guss VL; Corsa JA; Barten DM; Felsenstein KM; Roberts SB
    Bioorg Med Chem Lett; 2008 Jan; 18(1):175-8. PubMed ID: 18023581
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.