BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

97 related articles for article (PubMed ID: 20218620)

  • 21. Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists.
    Nakazato A; Sakagami K; Yasuhara A; Ohta H; Yoshikawa R; Itoh M; Nakamura M; Chaki S
    J Med Chem; 2004 Aug; 47(18):4570-87. PubMed ID: 15317467
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.
    Selvam C; Lemasson IA; Brabet I; Oueslati N; Karaman B; Cabaye A; Tora AS; Commare B; Courtiol T; Cesarini S; McCort-Tranchepain I; Rigault D; Mony L; Bessiron T; McLean H; Leroux FR; Colobert F; Daniel H; Goupil-Lamy A; Bertrand HO; Goudet C; Pin JP; Acher FC
    J Med Chem; 2018 Mar; 61(5):1969-1989. PubMed ID: 29397723
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators.
    Kubas H; Meyer U; Krueger B; Hechenberger M; Vanejevs M; Zemribo R; Kauss V; Ambartsumova R; Pyatkin I; Polosukhin AI; Abel U
    Bioorg Med Chem Lett; 2013 Aug; 23(16):4493-500. PubMed ID: 23856046
    [TBL] [Abstract][Full Text] [Related]  

  • 24. New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.
    Huynh TH; Erichsen MN; Tora AS; Goudet C; Sagot E; Assaf Z; Thomsen C; Brodbeck R; Stensbøl TB; Bjørn-Yoshimoto WE; Nielsen B; Pin JP; Gefflaut T; Bunch L
    J Med Chem; 2016 Feb; 59(3):914-24. PubMed ID: 26814576
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Amino-pyrrolidine tricarboxylic acids give new insight into group III metabotropic glutamate receptor activation mechanism.
    Frauli M; Hubert N; Schann S; Triballeau N; Bertrand HO; Acher F; Neuville P; Pin JP; Prézeau L
    Mol Pharmacol; 2007 Mar; 71(3):704-12. PubMed ID: 17167031
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Dual function glutamate-related ligands: discovery of a novel, potent inhibitor of glutamate carboxypeptidase II possessing mGluR3 agonist activity.
    Nan F; Bzdega T; Pshenichkin S; Wroblewski JT; Wroblewska B; Neale JH; Kozikowski AP
    J Med Chem; 2000 Mar; 43(5):772-4. PubMed ID: 10715144
    [No Abstract]   [Full Text] [Related]  

  • 27. Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists.
    Marinozzi M; Carotti A; Sansone E; Macchiarulo A; Rosatelli E; Sardella R; Natalini B; Rizzo G; Adorini L; Passeri D; De Franco F; Pruzanski M; Pellicciari R
    Bioorg Med Chem; 2012 Jun; 20(11):3429-45. PubMed ID: 22564381
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.
    Triballeau N; Acher F; Brabet I; Pin JP; Bertrand HO
    J Med Chem; 2005 Apr; 48(7):2534-47. PubMed ID: 15801843
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor.
    Cid JM; Lavreysen H; Tresadern G; Pérez-Benito L; Tovar F; Fontana A; Trabanco AA
    ACS Chem Neurosci; 2019 Mar; 10(3):1043-1054. PubMed ID: 30216043
    [TBL] [Abstract][Full Text] [Related]  

  • 30. The role of electrostatic interaction in the molecular recognition of selective agonists to metabotropic glutamate receptors.
    Macchiarulo A; Costantino G; Sbaglia R; Aiello S; Meniconi M; Pellicciari R
    Proteins; 2003 Mar; 50(4):609-19. PubMed ID: 12577267
    [TBL] [Abstract][Full Text] [Related]  

  • 31. A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action.
    Podkowa K; Rzeźniczek S; Marciniak M; Acher F; Pilc A; Pałucha-Poniewiera A
    Neuropharmacology; 2015 Oct; 97():338-45. PubMed ID: 26074092
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Exploration of structure-based drug design opportunities for mGluRs.
    Topiol S; Sabio M; Uberti M
    Neuropharmacology; 2011 Jan; 60(1):93-101. PubMed ID: 20705075
    [TBL] [Abstract][Full Text] [Related]  

  • 33. New probes of the agonist binding site of metabotropic glutamate receptors.
    Bessis AS; Bolte J; Pin JP; Acher F
    Bioorg Med Chem Lett; 2001 Jun; 11(12):1569-72. PubMed ID: 11412983
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Determination of the absolute configuration of phosphinic analogues of glutamate.
    Commare B; Rigault D; Lemasson IA; Deschamps P; Tomas A; Roussel P; Brabet I; Goudet C; Pin JP; Leroux FR; Colobert F; Acher FC
    Org Biomol Chem; 2015 Jan; 13(4):1106-12. PubMed ID: 25417857
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.
    Ivashkin P; Lemonnier G; Tora AS; Pin JP; Goudet C; Jubault P; Pannecoucke X
    Bioorg Med Chem Lett; 2015 Jun; 25(12):2523-6. PubMed ID: 25958247
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor.
    Rovira X; Harrak Y; Trapero A; González-Bulnes P; Malhaire F; Pin JP; Goudet C; Giraldo J; Llebaria A
    ChemMedChem; 2014 Dec; 9(12):2685-98. PubMed ID: 25196639
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.
    Beurrier C; Lopez S; Révy D; Selvam C; Goudet C; Lhérondel M; Gubellini P; Kerkerian-LeGoff L; Acher F; Pin JP; Amalric M
    FASEB J; 2009 Oct; 23(10):3619-28. PubMed ID: 19525404
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.
    Kulkarni SS; Nightingale B; Dersch CM; Rothman RB; Newman AH
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3371-5. PubMed ID: 16678408
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors.
    Rovira X; Malhaire F; Scholler P; Rodrigo J; Gonzalez-Bulnes P; Llebaria A; Pin JP; Giraldo J; Goudet C
    FASEB J; 2015 Jan; 29(1):116-30. PubMed ID: 25342125
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu
    Chen Q; Ho JD; Ashok S; Vargas MC; Wang J; Atwell S; Bures M; Schkeryantz JM; Monn JA; Hao J
    J Med Chem; 2018 Nov; 61(22):10040-10052. PubMed ID: 30365309
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.