196 related articles for article (PubMed ID: 20218628)
21. Design, synthesis, and evaluation of mixed imine-amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity.
Kamal A; Ramesh G; Srinivas O; Ramulu P; Laxman N; Rehana T; Deepak M; Achary MS; Nagarajaram HA
Bioorg Med Chem; 2004 Oct; 12(20):5427-36. PubMed ID: 15388169
[TBL] [Abstract][Full Text] [Related]
22. Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity.
Kamal A; Shankaraiah N; Prabhakar S; Reddy ChR; Markandeya N; Reddy KL; Devaiah V
Bioorg Med Chem Lett; 2008 Apr; 18(7):2434-9. PubMed ID: 18325766
[TBL] [Abstract][Full Text] [Related]
23. An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
Tiberghien AC; Evans DA; Kiakos K; Martin CR; Hartley JA; Thurston DE; Howard PW
Bioorg Med Chem Lett; 2008 Mar; 18(6):2073-7. PubMed ID: 18272367
[TBL] [Abstract][Full Text] [Related]
24. Dithiocarbamate/piperazine bridged pyrrolobenzodiazepines as DNA-minor groove binders: synthesis, DNA-binding affinity and cytotoxic activity.
Kamal A; Sreekanth K; Shankaraiah N; Sathish M; Nekkanti S; Srinivasulu V
Bioorg Chem; 2015 Apr; 59():23-30. PubMed ID: 25665519
[TBL] [Abstract][Full Text] [Related]
25. Synthesis and DNA-binding ability of pyrrolo[2,1-c][1,4]benzodiazepine-azepane conjugates.
Kamal A; Reddy DR; Reddy PS; Rajendar
Bioorg Med Chem Lett; 2006 Mar; 16(5):1160-3. PubMed ID: 16361097
[TBL] [Abstract][Full Text] [Related]
26. Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential.
Kamal A; Rajender ; Reddy DR; Reddy MK; Balakishan G; Shaik TB; Chourasia M; Sastry GN
Bioorg Med Chem; 2009 Feb; 17(4):1557-72. PubMed ID: 19168361
[TBL] [Abstract][Full Text] [Related]
27. Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.
Wilson SC; Howard PW; Forrow SM; Hartley JA; Adams LJ; Jenkins TC; Kelland LR; Thurston DE
J Med Chem; 1999 Oct; 42(20):4028-41. PubMed ID: 10514273
[TBL] [Abstract][Full Text] [Related]
28. Synthesis of aryl-substituted naphthalene-linked pyrrolobenzodiazepine conjugates as potential anticancer agents with apoptosis-inducing ability.
Kamal A; Reddy MK; Ramaiah MJ; Srikanth YV; Rajender ; Reddy VS; Kumar GB; Pushpavalli SN; Bag I; Juvekar A; Sen S; Zingde SM; Pal-Bhadra M
ChemMedChem; 2011 Sep; 6(9):1665-79. PubMed ID: 21732540
[TBL] [Abstract][Full Text] [Related]
29. NMR structural studies on the covalent DNA binding of a pyrrolobenzodiazepine-naphthalimide conjugate.
Rettig M; Langel W; Kamal A; Weisz K
Org Biomol Chem; 2010 Jul; 8(14):3179-87. PubMed ID: 20490406
[TBL] [Abstract][Full Text] [Related]
30. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
Hartley JA; Spanswick VJ; Brooks N; Clingen PH; McHugh PJ; Hochhauser D; Pedley RB; Kelland LR; Alley MC; Schultz R; Hollingshead MG; Schweikart KM; Tomaszewski JE; Sausville EA; Gregson SJ; Howard PW; Thurston DE
Cancer Res; 2004 Sep; 64(18):6693-9. PubMed ID: 15374986
[TBL] [Abstract][Full Text] [Related]
31. Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: synthesis, DNA interaction, cytotoxicity and differential cellular localization.
Wells G; Suggitt M; Coffils M; Baig MA; Howard PW; Loadman PM; Hartley JA; Jenkins TC; Thurston DE
Bioorg Med Chem Lett; 2008 Mar; 18(6):2147-51. PubMed ID: 18280154
[TBL] [Abstract][Full Text] [Related]
32. Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibition.
Jackson PJ; James CH; Jenkins TC; Rahman KM; Thurston DE
ACS Chem Biol; 2014 Oct; 9(10):2432-40. PubMed ID: 25111266
[TBL] [Abstract][Full Text] [Related]
33. Recent developments in novel pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis and biological evaluation.
Kumar R; Lown JW
Mini Rev Med Chem; 2003 Jun; 3(4):323-39. PubMed ID: 12678826
[TBL] [Abstract][Full Text] [Related]
34. Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation.
Seifert J; Pezeshki S; Kamal A; Weisz K
Org Biomol Chem; 2012 Sep; 10(34):6850-60. PubMed ID: 22837138
[TBL] [Abstract][Full Text] [Related]
35. Design and synthesis of benzo[c,d]indolone-pyrrolobenzodiazepine conjugates as potential anticancer agents.
Kamal A; Ramakrishna G; Lakshma Nayak V; Raju P; Subba Rao AV; Viswanath A; Vishnuvardhan MV; Ramakrishna S; Srinivas G
Bioorg Med Chem; 2012 Jan; 20(2):789-800. PubMed ID: 22209733
[TBL] [Abstract][Full Text] [Related]
36. Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential.
Kamal A; Reddy PS; Reddy DR; Laxman E; Murthy YL
Bioorg Med Chem Lett; 2004 Nov; 14(22):5699-702. PubMed ID: 15482951
[TBL] [Abstract][Full Text] [Related]
37. Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug.
Berry JM; Howard PW; Kelland LR; Thurston DE
Bioorg Med Chem Lett; 2002 May; 12(10):1413-6. PubMed ID: 11992788
[TBL] [Abstract][Full Text] [Related]
38. Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization.
Antonow D; Barata T; Jenkins TC; Parkinson GN; Howard PW; Thurston DE; Zloh M
Biochemistry; 2008 Nov; 47(45):11818-29. PubMed ID: 18925745
[TBL] [Abstract][Full Text] [Related]
39. Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.
Baraldi PG; Cacciari B; Guiotto A; Leoni A; Romagnoli R; Spalluto G; Mongelli N; Howard PW; Thurston DE; Bianchi N; Gambari R
Bioorg Med Chem Lett; 1998 Nov; 8(21):3019-24. PubMed ID: 9873668
[TBL] [Abstract][Full Text] [Related]
40. Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
Kamal A; Ramulu P; Srinivas O; Ramesh G
Bioorg Med Chem Lett; 2003 Nov; 13(22):3955-8. PubMed ID: 14592483
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
