BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

61 related articles for article (PubMed ID: 20224283)

  • 1. Effect of heparin on APP metabolism and Abeta production in cortical neurons.
    Klaver D; Hung AC; Gasperini R; Foa L; Aguilar MI; Small DH
    Neurodegener Dis; 2010; 7(1-3):187-9. PubMed ID: 20224283
    [TBL] [Abstract][Full Text] [Related]  

  • 2. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
    Nishitomi K; Sakaguchi G; Horikoshi Y; Gray AJ; Maeda M; Hirata-Fukae C; Becker AG; Hosono M; Sakaguchi I; Minami SS; Nakajima Y; Li HF; Takeyama C; Kihara T; Ota A; Wong PC; Aisen PS; Kato A; Kinoshita N; Matsuoka Y
    J Neurochem; 2006 Dec; 99(6):1555-63. PubMed ID: 17083447
    [TBL] [Abstract][Full Text] [Related]  

  • 3. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
    Meredith JE; Thompson LA; Toyn JH; Marcin L; Barten DM; Marcinkeviciene J; Kopcho L; Kim Y; Lin A; Guss V; Burton C; Iben L; Polson C; Cantone J; Ford M; Drexler D; Fiedler T; Lentz KA; Grace JE; Kolb J; Corsa J; Pierdomenico M; Jones K; Olson RE; Macor JE; Albright CF
    J Pharmacol Exp Ther; 2008 Aug; 326(2):502-13. PubMed ID: 18499745
    [TBL] [Abstract][Full Text] [Related]  

  • 4. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Shi XP; Tugusheva K; Tyler KX; Kahana J; Ellis J; Jin L; Steele T; Stachel S; Coburn C; Simon AJ
    J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
    [TBL] [Abstract][Full Text] [Related]  

  • 5. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters.
    Lin HC; Hsieh HM; Chen YH; Hu ML
    Neurotoxicology; 2009 Jul; 30(4):622-7. PubMed ID: 19635394
    [TBL] [Abstract][Full Text] [Related]  

  • 6. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
    Majercak J; Ray WJ; Espeseth A; Simon A; Shi XP; Wolffe C; Getty K; Marine S; Stec E; Ferrer M; Strulovici B; Bartz S; Gates A; Xu M; Huang Q; Ma L; Shughrue P; Burchard J; Colussi D; Pietrak B; Kahana J; Beher D; Rosahl T; Shearman M; Hazuda D; Sachs AB; Koblan KS; Seabrook GR; Stone DJ
    Proc Natl Acad Sci U S A; 2006 Nov; 103(47):17967-72. PubMed ID: 17098871
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Size and sulfation are critical for the effect of heparin on APP processing and Aβ production.
    Cui H; Hung AC; Freeman C; Narkowicz C; Jacobson GA; Small DH
    J Neurochem; 2012 Nov; 123(3):447-57. PubMed ID: 22909067
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems.
    Volbracht C; Penzkofer S; Mansson D; Christensen KV; Fog K; Schildknecht S; Leist M; Nielsen J
    Anal Biochem; 2009 Apr; 387(2):208-20. PubMed ID: 19454261
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent.
    Hartlage-Rübsamen M; Zeitschel U; Apelt J; Gärtner U; Franke H; Stahl T; Günther A; Schliebs R; Penkowa M; Bigl V; Rossner S
    Glia; 2003 Jan; 41(2):169-79. PubMed ID: 12509807
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Differential effects of gamma-secretase and BACE1 inhibition on brain Abeta levels in vitro and in vivo.
    Elvang AB; Volbracht C; Pedersen LØ; Jensen KG; Karlsson JJ; Larsen SA; Mørk A; Stensbøl TB; Bastlund JF
    J Neurochem; 2009 Sep; 110(5):1377-87. PubMed ID: 19519664
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H; Sultana R; Keller JN; St Clair DK; Markesbery WR; Butterfield DA
    J Neurochem; 2006 Mar; 96(5):1322-35. PubMed ID: 16478525
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
    Asai M; Hattori C; Iwata N; Saido TC; Sasagawa N; Szabó B; Hashimoto Y; Maruyama K; Tanuma S; Kiso Y; Ishiura S
    J Neurochem; 2006 Jan; 96(2):533-40. PubMed ID: 16336629
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
    Ohno M; Chang L; Tseng W; Oakley H; Citron M; Klein WL; Vassar R; Disterhoft JF
    Eur J Neurosci; 2006 Jan; 23(1):251-60. PubMed ID: 16420434
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription.
    Li Y; Zhou W; Tong Y; He G; Song W
    FASEB J; 2006 Feb; 20(2):285-92. PubMed ID: 16449801
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.
    Cui H; Hung AC; Klaver DW; Suzuki T; Freeman C; Narkowicz C; Jacobson GA; Small DH
    PLoS One; 2011; 6(7):e23007. PubMed ID: 21829577
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.
    Fu H; Dou J; Li W; Cui W; Mak S; Hu Q; Luo J; Lam CS; Pang Y; Youdim MB; Han Y
    Eur J Pharmacol; 2009 Nov; 623(1-3):14-21. PubMed ID: 19765582
    [TBL] [Abstract][Full Text] [Related]  

  • 18. beta-Secretase, APP and Abeta in Alzheimer's disease.
    Vassar R
    Subcell Biochem; 2005; 38():79-103. PubMed ID: 15709474
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel approach for studying endogenous abeta processing using cultured primary neurons isolated from APP transgenic mice.
    Qiu Z; Naten DL; Liston JC; Yess J; Rebeck GW
    Exp Neurol; 2001 Jul; 170(1):186-94. PubMed ID: 11421596
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.
    Philipson O; Lannfelt L; Nilsson LN
    FEBS Lett; 2009 Sep; 583(18):3021-6. PubMed ID: 19683527
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.