BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

297 related articles for article (PubMed ID: 20236310)

  • 1. Mixed lineage leukemia: a structure-function perspective of the MLL1 protein.
    Cosgrove MS; Patel A
    FEBS J; 2010 Apr; 277(8):1832-42. PubMed ID: 20236310
    [TBL] [Abstract][Full Text] [Related]  

  • 2. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
    Patel A; Dharmarajan V; Vought VE; Cosgrove MS
    J Biol Chem; 2009 Sep; 284(36):24242-56. PubMed ID: 19556245
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
    Patel A; Vought VE; Swatkoski S; Viggiano S; Howard B; Dharmarajan V; Monteith KE; Kupakuwana G; Namitz KE; Shinsky SA; Cotter RJ; Cosgrove MS
    J Biol Chem; 2014 Jan; 289(2):868-84. PubMed ID: 24235145
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.
    Shinsky SA; Monteith KE; Viggiano S; Cosgrove MS
    J Biol Chem; 2015 Mar; 290(10):6361-75. PubMed ID: 25561738
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
    Dharmarajan V; Lee JH; Patel A; Skalnik DG; Cosgrove MS
    J Biol Chem; 2012 Aug; 287(33):27275-89. PubMed ID: 22665483
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.
    Shinsky SA; Hu M; Vought VE; Ng SB; Bamshad MJ; Shendure J; Cosgrove MS
    J Mol Biol; 2014 Jun; 426(12):2283-99. PubMed ID: 24680668
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks.
    Southall SM; Wong PS; Odho Z; Roe SM; Wilson JR
    Mol Cell; 2009 Jan; 33(2):181-91. PubMed ID: 19187761
    [TBL] [Abstract][Full Text] [Related]  

  • 8. An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.
    Cao F; Chen Y; Cierpicki T; Liu Y; Basrur V; Lei M; Dou Y
    PLoS One; 2010 Nov; 5(11):e14102. PubMed ID: 21124902
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
    Alicea-Velázquez NL; Shinsky SA; Loh DM; Lee JH; Skalnik DG; Cosgrove MS
    J Biol Chem; 2016 Oct; 291(43):22357-22372. PubMed ID: 27563068
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.
    Ruthenburg AJ; Wang W; Graybosch DM; Li H; Allis CD; Patel DJ; Verdine GL
    Nat Struct Mol Biol; 2006 Aug; 13(8):704-12. PubMed ID: 16829959
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of MLL1 H3K4 methyltransferase activity by its core components.
    Dou Y; Milne TA; Ruthenburg AJ; Lee S; Lee JW; Verdine GL; Allis CD; Roeder RG
    Nat Struct Mol Biol; 2006 Aug; 13(8):713-9. PubMed ID: 16878130
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex.
    Patel A; Vought VE; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2008 Nov; 283(47):32162-75. PubMed ID: 18829457
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural insights on the KMT2-NCP interaction.
    Yang Z; Zepeda R; Dou Y
    Biochem Soc Trans; 2023 Feb; 51(1):427-434. PubMed ID: 36695549
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural basis of nucleosome recognition and modification by MLL methyltransferases.
    Xue H; Yao T; Cao M; Zhu G; Li Y; Yuan G; Chen Y; Lei M; Huang J
    Nature; 2019 Sep; 573(7774):445-449. PubMed ID: 31485071
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.
    Patel A; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2008 Nov; 283(47):32158-61. PubMed ID: 18829459
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The many facets of MLL1 regulation.
    Zhang P; Bergamin E; Couture JF
    Biopolymers; 2013 Feb; 99(2):136-45. PubMed ID: 23175388
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex.
    Patel A; Vought VE; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2011 Feb; 286(5):3359-69. PubMed ID: 21106533
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural basis for activity regulation of MLL family methyltransferases.
    Li Y; Han J; Zhang Y; Cao F; Liu Z; Li S; Wu J; Hu C; Wang Y; Shuai J; Chen J; Cao L; Li D; Shi P; Tian C; Zhang J; Dou Y; Li G; Chen Y; Lei M
    Nature; 2016 Feb; 530(7591):447-52. PubMed ID: 26886794
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.
    Wang P; Lin C; Smith ER; Guo H; Sanderson BW; Wu M; Gogol M; Alexander T; Seidel C; Wiedemann LM; Ge K; Krumlauf R; Shilatifard A
    Mol Cell Biol; 2009 Nov; 29(22):6074-85. PubMed ID: 19703992
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
    Park SH; Ayoub A; Lee YT; Xu J; Kim H; Zheng W; Zhang B; Sha L; An S; Zhang Y; Cianfrocco MA; Su M; Dou Y; Cho US
    Nat Commun; 2019 Dec; 10(1):5540. PubMed ID: 31804488
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.