BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

200 related articles for article (PubMed ID: 20345925)

  • 1. Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells.
    Mann A; Tyndale RF
    Eur J Neurosci; 2010 Apr; 31(7):1185-93. PubMed ID: 20345925
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models.
    Chattopadhyay M; Chowdhury AR; Feng T; Assenmacher CA; Radaelli E; Guengerich FP; Avadhani NG
    J Biol Chem; 2019 Jun; 294(26):10336-10348. PubMed ID: 31113867
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
    Bajpai P; Sangar MC; Singh S; Tang W; Bansal S; Chowdhury G; Cheng Q; Fang JK; Martin MV; Guengerich FP; Avadhani NG
    J Biol Chem; 2013 Feb; 288(6):4436-51. PubMed ID: 23258538
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
    Coleman T; Ellis SW; Martin IJ; Lennard MS; Tucker GT
    J Pharmacol Exp Ther; 1996 May; 277(2):685-90. PubMed ID: 8627546
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.
    Singh S; Singh K; Patel DK; Singh C; Nath C; Singh VK; Singh RK; Singh MP
    Rejuvenation Res; 2009 Jun; 12(3):185-97. PubMed ID: 19594327
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone.
    Samer CF; Daali Y; Wagner M; Hopfgartner G; Eap CB; Rebsamen MC; Rossier MF; Hochstrasser D; Dayer P; Desmeules JA
    Br J Pharmacol; 2010 Jun; 160(4):907-18. PubMed ID: 20590587
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Overexpression of CYP2D6 attenuates the toxicity of MPP+ in actively dividing and differentiated PC12 cells.
    Matoh N; Tanaka S; Takehashi M; Banasik M; Stedeford T; Masliah E; Suzuki S; Nishimura Y; Ueda K
    Gene Expr; 2003; 11(3-4):117-24. PubMed ID: 14686785
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Meloxicam protects cell damage from 1-methyl-4-phenyl pyridinium toxicity via the phosphatidylinositol 3-kinase/Akt pathway in human dopaminergic neuroblastoma SH-SY5Y cells.
    Tasaki Y; Omura T; Yamada T; Ohkubo T; Suno M; Iida S; Sakaguchi T; Asari M; Shimizu K; Matsubara K
    Brain Res; 2010 Jul; 1344():25-33. PubMed ID: 20452332
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs.
    Venkatakrishnan K; von Moltke LL; Greenblatt DJ
    J Clin Pharmacol; 1999 Jun; 39(6):567-77. PubMed ID: 10354960
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
    Herraiz T; Guillén H; Arán VJ; Idle JR; Gonzalez FJ
    Toxicol Appl Pharmacol; 2006 Nov; 216(3):387-98. PubMed ID: 16870220
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Influence of lipophilicity on the interactions of N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and their positively charged N-alkyl-4-phenylpyridinium metabolites with cytochrome P450 2D6.
    Kalgutkar AS; Zhou S; Fahmi OA; Taylor TJ
    Drug Metab Dispos; 2003 May; 31(5):596-605. PubMed ID: 12695348
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.
    Gilham DE; Cairns W; Paine MJ; Modi S; Poulsom R; Roberts GC; Wolf CR
    Xenobiotica; 1997 Jan; 27(1):111-25. PubMed ID: 9041683
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The novel squamosamide derivative (compound FLZ) attenuated 1-methyl, 4-phenyl-pyridinium ion (MPP+)-induced apoptosis and alternations of related signal transduction in SH-SY5Y cells.
    Zhang D; Zhang JJ; Liu GT
    Neuropharmacology; 2007 Feb; 52(2):423-9. PubMed ID: 17055540
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.
    Mann A; Miksys SL; Gaedigk A; Kish SJ; Mash DC; Tyndale RF
    Neurobiol Aging; 2012 Sep; 33(9):2160-71. PubMed ID: 21958961
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development.
    Zhou SF; Liu JP; Lai XS
    Curr Med Chem; 2009; 16(21):2661-805. PubMed ID: 19601803
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Down-regulation of natural resistance-associated macrophage protein-1 (Nramp1) is associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/1-methyl-4-phenylpyridinium (MPP
    Wu KC; Liou HH; Lee CY; Lin CJ
    Neuropathol Appl Neurobiol; 2019 Feb; 45(2):157-173. PubMed ID: 29679389
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The use of 3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin (AMMC) as a specific CYP2D6 probe in human liver microsomes.
    Chauret N; Dobbs B; Lackman RL; Bateman K; Nicoll-Griffith DA; Stresser DM; Ackermann JM; Turner SD; Miller VP; Crespi CL
    Drug Metab Dispos; 2001 Sep; 29(9):1196-200. PubMed ID: 11502727
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6.
    Desta Z; Wu GM; Morocho AM; Flockhart DA
    Drug Metab Dispos; 2002 Mar; 30(3):336-43. PubMed ID: 11854155
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells.
    Fang J; Zuo D; Yu PH
    Psychopharmacology (Berl); 1995 Oct; 121(3):373-8. PubMed ID: 8584620
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Timolol metabolism in human liver microsomes is mediated principally by CYP2D6.
    Volotinen M; Turpeinen M; Tolonen A; Uusitalo J; Mäenpää J; Pelkonen O
    Drug Metab Dispos; 2007 Jul; 35(7):1135-41. PubMed ID: 17431033
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.