BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

110 related articles for article (PubMed ID: 20347304)

  • 1. Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.
    Shook BC; Rassnick S; Hall D; Rupert KC; Heintzelman GR; Hansen K; Chakravarty D; Bullington JL; Scannevin RH; Magliaro B; Westover L; Carroll K; Lampron L; Russell R; Branum S; Wells K; Damon S; Youells S; Li X; Osbourne M; Demarest K; Tang Y; Rhodes K; Jackson PF
    Bioorg Med Chem Lett; 2010 May; 20(9):2864-7. PubMed ID: 20347304
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.
    Shook BC; Rassnick S; Chakravarty D; Wallace N; Ault M; Crooke J; Barbay JK; Wang A; Leonard K; Powell MT; Alford V; Hall D; Rupert KC; Heintzelman GR; Hansen K; Bullington JL; Scannevin RH; Carroll K; Lampron L; Westover L; Russell R; Branum S; Wells K; Damon S; Youells S; Beauchamp D; Li X; Rhodes K; Jackson PF
    Bioorg Med Chem Lett; 2010 May; 20(9):2868-71. PubMed ID: 20338760
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: highly potent, orally active, adenosine A2A antagonists. Part 1.
    Matasi JJ; Caldwell JP; Zhang H; Fawzi A; Cohen-Williams ME; Varty GB; Tulshian DB
    Bioorg Med Chem Lett; 2005 Aug; 15(16):3670-4. PubMed ID: 15978806
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.
    Gillespie RJ; Cliffe IA; Dawson CE; Dourish CT; Gaur S; Giles PR; Jordan AM; Knight AR; Lawrence A; Lerpiniere J; Misra A; Pratt RM; Todd RS; Upton R; Weiss SM; Williamson DS
    Bioorg Med Chem Lett; 2008 May; 18(9):2920-3. PubMed ID: 18407496
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.
    Neustadt BR; Hao J; Lindo N; Greenlee WJ; Stamford AW; Tulshian D; Ongini E; Hunter J; Monopoli A; Bertorelli R; Foster C; Arik L; Lachowicz J; Ng K; Feng KI
    Bioorg Med Chem Lett; 2007 Mar; 17(5):1376-80. PubMed ID: 17236762
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.
    Peng H; Kumaravel G; Yao G; Sha L; Wang J; Van Vlijmen H; Bohnert T; Huang C; Vu CB; Ensinger CL; Chang H; Engber TM; Whalley ET; Petter RC
    J Med Chem; 2004 Dec; 47(25):6218-29. PubMed ID: 15566292
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.
    Gillespie RJ; Bamford SJ; Botting R; Comer M; Denny S; Gaur S; Griffin M; Jordan AM; Knight AR; Lerpiniere J; Leonardi S; Lightowler S; McAteer S; Merrett A; Misra A; Padfield A; Reece M; Saadi M; Selwood DL; Stratton GC; Surry D; Todd R; Tong X; Ruston V; Upton R; Weiss SM
    J Med Chem; 2009 Jan; 52(1):33-47. PubMed ID: 19072055
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.
    Gillespie RJ; Cliffe IA; Dawson CE; Dourish CT; Gaur S; Jordan AM; Knight AR; Lerpiniere J; Misra A; Pratt RM; Roffey J; Stratton GC; Upton R; Weiss SM; Williamson DS
    Bioorg Med Chem Lett; 2008 May; 18(9):2924-9. PubMed ID: 18411049
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides.
    Gillespie RJ; Bamford SJ; Clay A; Gaur S; Haymes T; Jackson PS; Jordan AM; Klenke B; Leonardi S; Liu J; Mansell HL; Ng S; Saadi M; Simmonite H; Stratton GC; Todd RS; Williamson DS; Yule IA
    Bioorg Med Chem; 2009 Sep; 17(18):6590-605. PubMed ID: 19695884
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles.
    Vu CB; Pan D; Peng B; Sha L; Kumaravel G; Jin X; Phadke D; Engber T; Huang C; Reilly J; Tam S; Petter RC
    Bioorg Med Chem Lett; 2004 Oct; 14(19):4831-4. PubMed ID: 15341933
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs as adenosine A2A antagonists: the successful reduction of hERG activity. Part 2.
    Matasi JJ; Caldwell JP; Zhang H; Fawzi A; Higgins GA; Cohen-Williams ME; Varty GB; Tulshian DB
    Bioorg Med Chem Lett; 2005 Aug; 15(16):3675-8. PubMed ID: 15982882
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists.
    Yao G; Haque S; Sha L; Kumaravel G; Wang J; Engber TM; Whalley ET; Conlon PR; Chang H; Kiesman WF; Petter RC
    Bioorg Med Chem Lett; 2005 Feb; 15(3):511-5. PubMed ID: 15664803
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists.
    Vu CB; Shields P; Peng B; Kumaravel G; Jin X; Phadke D; Wang J; Engber T; Ayyub E; Petter RC
    Bioorg Med Chem Lett; 2004 Oct; 14(19):4835-8. PubMed ID: 15341934
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists.
    Shook BC; Chakravarty D; Barbay JK; Wang A; Leonard K; Alford V; Powell MT; Rassnick S; Scannevin RH; Carroll K; Wallace N; Crooke J; Ault M; Lampron L; Westover L; Rhodes K; Jackson PF
    Bioorg Med Chem Lett; 2013 May; 23(9):2688-91. PubMed ID: 23522563
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.
    Cheong SL; Dolzhenko A; Kachler S; Paoletta S; Federico S; Cacciari B; Dolzhenko A; Klotz KN; Moro S; Spalluto G; Pastorin G
    J Med Chem; 2010 Apr; 53(8):3361-75. PubMed ID: 20307065
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 2-Amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists: 2. Reduction of hERG activity, observed species selectivity, and structure-activity relationships.
    Slee DH; Moorjani M; Zhang X; Lin E; Lanier MC; Chen Y; Rueter JK; Lechner SM; Markison S; Malany S; Joswig T; Santos M; Gross RS; Williams JP; Castro-Palomino JC; Crespo MI; Prat M; Gual S; Díaz JL; Jalali K; Sai Y; Zuo Z; Yang C; Wen J; O'Brien Z; Petroski R; Saunders J
    J Med Chem; 2008 Mar; 51(6):1730-9. PubMed ID: 18307293
    [TBL] [Abstract][Full Text] [Related]  

  • 17. N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy.
    Lanier MC; Moorjani M; Luo Z; Chen Y; Lin E; Tellew JE; Zhang X; Williams JP; Gross RS; Lechner SM; Markison S; Joswig T; Kargo W; Piercey J; Santos M; Malany S; Zhao M; Petroski R; Crespo MI; Díaz JL; Saunders J; Wen J; O'Brien Z; Jalali K; Madan A; Slee DH
    J Med Chem; 2009 Feb; 52(3):709-17. PubMed ID: 19140664
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in models of Parkinson's disease and cognition.
    Mihara T; Mihara K; Yarimizu J; Mitani Y; Matsuda R; Yamamoto H; Aoki S; Akahane A; Iwashita A; Matsuoka N
    J Pharmacol Exp Ther; 2007 Nov; 323(2):708-19. PubMed ID: 17684118
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The discovery and synthesis of novel adenosine receptor (A(2A)) antagonists.
    Matasi JJ; Caldwell JP; Hao J; Neustadt B; Arik L; Foster CJ; Lachowicz J; Tulshian DB
    Bioorg Med Chem Lett; 2005 Mar; 15(5):1333-6. PubMed ID: 15713381
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides.
    Gillespie RJ; Bamford SJ; Gaur S; Jordan AM; Lerpiniere J; Mansell HL; Stratton GC
    Bioorg Med Chem Lett; 2009 May; 19(10):2664-7. PubMed ID: 19362836
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.