335 related articles for article (PubMed ID: 20347593)
1. Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
Cumming J; Babu S; Huang Y; Carrol C; Chen X; Favreau L; Greenlee W; Guo T; Kennedy M; Kuvelkar R; Le T; Li G; McHugh N; Orth P; Ozgur L; Parker E; Saionz K; Stamford A; Strickland C; Tadesse D; Voigt J; Zhang L; Zhang Q
Bioorg Med Chem Lett; 2010 May; 20(9):2837-42. PubMed ID: 20347593
[TBL] [Abstract][Full Text] [Related]
2. Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.
Cumming JN; Le TX; Babu S; Carroll C; Chen X; Favreau L; Gaspari P; Guo T; Hobbs DW; Huang Y; Iserloh U; Kennedy ME; Kuvelkar R; Li G; Lowrie J; McHugh NA; Ozgur L; Pan J; Parker EM; Saionz K; Stamford AW; Strickland C; Tadesse D; Voigt J; Wang L; Wu Y; Zhang L; Zhang Q
Bioorg Med Chem Lett; 2008 Jun; 18(11):3236-41. PubMed ID: 18468890
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
Ghosh AK; Kumaragurubaran N; Hong L; Kulkarni SS; Xu X; Chang W; Weerasena V; Turner R; Koelsch G; Bilcer G; Tang J
J Med Chem; 2007 May; 50(10):2399-407. PubMed ID: 17432843
[TBL] [Abstract][Full Text] [Related]
4. Pyridinyl aminohydantoins as small molecule BACE1 inhibitors.
Zhou P; Li Y; Fan Y; Wang Z; Chopra R; Olland A; Hu Y; Magolda RL; Pangalos M; Reinhart PH; Turner MJ; Bard J; Malamas MS; Robichaud AJ
Bioorg Med Chem Lett; 2010 Apr; 20(7):2326-9. PubMed ID: 20202842
[TBL] [Abstract][Full Text] [Related]
5. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Probst GD; Bowers S; Sealy JM; Stupi B; Dressen D; Jagodzinska BM; Aquino J; Gailunas A; Truong AP; Tso L; Xu YZ; Hom RK; John V; Tung JS; Pleiss MA; Tucker JA; Konradi AW; Sham HL; Jagodzinski J; Toth G; Brecht E; Yao N; Pan H; Lin M; Artis DR; Ruslim L; Bova MP; Sinha S; Yednock TA; Gauby S; Zmolek W; Quinn KP; Sauer JM
Bioorg Med Chem Lett; 2010 Oct; 20(20):6034-9. PubMed ID: 20822903
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues.
Bäck M; Nyhlén J; Kvarnström I; Appelgren S; Borkakoti N; Jansson K; Lindberg J; Nyström S; Hallberg A; Rosenquist S; Samuelsson B
Bioorg Med Chem; 2008 Nov; 16(21):9471-86. PubMed ID: 18842420
[TBL] [Abstract][Full Text] [Related]
7. Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors.
Malamas MS; Erdei J; Gunawan I; Barnes K; Johnson M; Hui Y; Turner J; Hu Y; Wagner E; Fan K; Olland A; Bard J; Robichaud AJ
J Med Chem; 2009 Oct; 52(20):6314-23. PubMed ID: 19757823
[TBL] [Abstract][Full Text] [Related]
8. Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
Bergstrom CP; Sloan CP; Wang HH; Parker MF; Smith DW; Zheng M; Hansel SB; Polson CT; Barber LE; Bursuker I; Guss VL; Corsa JA; Barten DM; Felsenstein KM; Roberts SB
Bioorg Med Chem Lett; 2008 Jan; 18(1):175-8. PubMed ID: 18023581
[TBL] [Abstract][Full Text] [Related]
9. Differential effects of gamma-secretase and BACE1 inhibition on brain Abeta levels in vitro and in vivo.
Elvang AB; Volbracht C; Pedersen LØ; Jensen KG; Karlsson JJ; Larsen SA; Mørk A; Stensbøl TB; Bastlund JF
J Neurochem; 2009 Sep; 110(5):1377-87. PubMed ID: 19519664
[TBL] [Abstract][Full Text] [Related]
10. Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
Malamas MS; Erdei J; Gunawan I; Turner J; Hu Y; Wagner E; Fan K; Chopra R; Olland A; Bard J; Jacobsen S; Magolda RL; Pangalos M; Robichaud AJ
J Med Chem; 2010 Feb; 53(3):1146-58. PubMed ID: 19968289
[TBL] [Abstract][Full Text] [Related]
11. Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Cumming JN; Smith EM; Wang L; Misiaszek J; Durkin J; Pan J; Iserloh U; Wu Y; Zhu Z; Strickland C; Voigt J; Chen X; Kennedy ME; Kuvelkar R; Hyde LA; Cox K; Favreau L; Czarniecki MF; Greenlee WJ; McKittrick BA; Parker EM; Stamford AW
Bioorg Med Chem Lett; 2012 Apr; 22(7):2444-9. PubMed ID: 22390835
[TBL] [Abstract][Full Text] [Related]
12. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Shi XP; Tugusheva K; Tyler KX; Kahana J; Ellis J; Jin L; Steele T; Stachel S; Coburn C; Simon AJ
J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
[TBL] [Abstract][Full Text] [Related]
13. Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.
Piazzi L; Cavalli A; Colizzi F; Belluti F; Bartolini M; Mancini F; Recanatini M; Andrisano V; Rampa A
Bioorg Med Chem Lett; 2008 Jan; 18(1):423-6. PubMed ID: 17998161
[TBL] [Abstract][Full Text] [Related]
14. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
Meredith JE; Thompson LA; Toyn JH; Marcin L; Barten DM; Marcinkeviciene J; Kopcho L; Kim Y; Lin A; Guss V; Burton C; Iben L; Polson C; Cantone J; Ford M; Drexler D; Fiedler T; Lentz KA; Grace JE; Kolb J; Corsa J; Pierdomenico M; Jones K; Olson RE; Macor JE; Albright CF
J Pharmacol Exp Ther; 2008 Aug; 326(2):502-13. PubMed ID: 18499745
[TBL] [Abstract][Full Text] [Related]
15. Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.
Machauer R; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Neumann U; Paganetti P
Bioorg Med Chem Lett; 2009 Mar; 19(5):1361-5. PubMed ID: 19195886
[TBL] [Abstract][Full Text] [Related]
16. Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
Bergstrom CP; Sloan CP; Lau WY; Smith DW; Zheng M; Hansel SB; Polson CT; Corsa JA; Barten DM; Felsenstein KM; Roberts SB
Bioorg Med Chem Lett; 2008 Jan; 18(2):464-8. PubMed ID: 18178084
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
Pu J; Kreft AF; Aschmies SH; Atchison KP; Berkowitz J; Caggiano TJ; Chlenov M; Diamantidis G; Harrison BL; Hu Y; Huryn D; Steven Jacobsen J; Jin M; Lipinski K; Lu P; Martone RL; Morris K; Sonnenberg-Reines J; Riddell DR; Sabalski J; Sun SC; Wagner E; Wang Y; Xu Z; Zhou H; Resnick L
Bioorg Med Chem; 2009 Jul; 17(13):4708-17. PubMed ID: 19443228
[TBL] [Abstract][Full Text] [Related]
18. Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.
Charrier N; Clarke B; Demont E; Dingwall C; Dunsdon R; Hawkins J; Hubbard J; Hussain I; Maile G; Matico R; Mosley J; Naylor A; O'Brien A; Redshaw S; Rowland P; Soleil V; Smith KJ; Sweitzer S; Theobald P; Vesey D; Walter DS; Wayne G
Bioorg Med Chem Lett; 2009 Jul; 19(13):3669-73. PubMed ID: 19477642
[TBL] [Abstract][Full Text] [Related]
19. Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.
Malamas MS; Barnes K; Hui Y; Johnson M; Lovering F; Condon J; Fobare W; Solvibile W; Turner J; Hu Y; Manas ES; Fan K; Olland A; Chopra R; Bard J; Pangalos MN; Reinhart P; Robichaud AJ
Bioorg Med Chem Lett; 2010 Apr; 20(7):2068-73. PubMed ID: 20223661
[TBL] [Abstract][Full Text] [Related]
20. Design of potent inhibitors of human beta-secretase. Part 1.
Freskos JN; Fobian YM; Benson TE; Bienkowski MJ; Brown DL; Emmons TL; Heintz R; Laborde A; McDonald JJ; Mischke BV; Molyneaux JM; Moon JB; Mullins PB; Bryan Prince D; Paddock DJ; Tomasselli AG; Winterrowd G
Bioorg Med Chem Lett; 2007 Jan; 17(1):73-7. PubMed ID: 17046251
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]