BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

292 related articles for article (PubMed ID: 20363126)

  • 1. The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.
    Cheng H; Hoffman J; Le P; Nair SK; Cripps S; Matthews J; Smith C; Yang M; Kupchinsky S; Dress K; Edwards M; Cole B; Walters E; Loh C; Ermolieff J; Fanjul A; Bhat GB; Herrera J; Pauly T; Hosea N; Paderes G; Rejto P
    Bioorg Med Chem Lett; 2010 May; 20(9):2897-902. PubMed ID: 20363126
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.
    Webster SP; Ward P; Binnie M; Craigie E; McConnell KM; Sooy K; Vinter A; Seckl JR; Walker BR
    Bioorg Med Chem Lett; 2007 May; 17(10):2838-43. PubMed ID: 17350260
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
    Johansson L; Fotsch C; Bartberger MD; Castro VM; Chen M; Emery M; Gustafsson S; Hale C; Hickman D; Homan E; Jordan SR; Komorowski R; Li A; McRae K; Moniz G; Matsumoto G; Orihuela C; Palm G; Veniant M; Wang M; Williams M; Zhang J
    J Med Chem; 2008 May; 51(10):2933-43. PubMed ID: 18419108
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.
    Shah U; Boyle CD; Chackalamannil S; Baker H; Kowalski T; Lee J; Terracina G; Zhang L
    Bioorg Med Chem Lett; 2010 Mar; 20(5):1551-4. PubMed ID: 20149650
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of adamantyl ethanone derivatives as potent 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors.
    Su X; Pradaux-Caggiano F; Thomas MP; Szeto MW; Halem HA; Culler MD; Vicker N; Potter BV
    ChemMedChem; 2010 Jul; 5(7):1026-44. PubMed ID: 20486152
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.
    Yeh VS; Kurukulasuriya R; Madar D; Patel JR; Fung S; Monzon K; Chiou W; Wang J; Jacobson P; Sham HL; Link JT
    Bioorg Med Chem Lett; 2006 Oct; 16(20):5408-13. PubMed ID: 16890427
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Roche D; Carniato D; Leriche C; Lepifre F; Christmann-Franck S; Graedler U; Charon C; Bozec S; Doare L; Schmidlin F; Lecomte M; Valeur E
    Bioorg Med Chem Lett; 2009 May; 19(10):2674-8. PubMed ID: 19395260
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type I.
    Valeur E; Christmann-Franck S; Lepifre F; Carniato D; Cravo D; Charon C; Bozec S; Musil D; Hillertz P; Doare L; Schmidlin F; Lecomte M; Schultz M; Roche D
    Bioorg Med Chem Lett; 2012 Sep; 22(18):5909-14. PubMed ID: 22901389
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.
    Yeh VS; Patel JR; Yong H; Kurukulasuriya R; Fung S; Monzon K; Chiou W; Wang J; Stolarik D; Imade H; Beno D; Brune M; Jacobson P; Sham H; Link JT
    Bioorg Med Chem Lett; 2006 Oct; 16(20):5414-9. PubMed ID: 16899366
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and 11β hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group.
    Kwon SW; Kang SK; Lee JH; Bok JH; Kim CH; Dal Rhee S; Jung WH; Kim HY; Bae MA; Song JS; Ha DC; Cheon HG; Kim KY; Ahn JH
    Bioorg Med Chem Lett; 2011 Jan; 21(1):435-9. PubMed ID: 21093259
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold.
    Lepifre F; Christmann-Franck S; Roche D; Leriche C; Carniato D; Charon C; Bozec S; Doare L; Schmidlin F; Lecomte M; Valeur E
    Bioorg Med Chem Lett; 2009 Jul; 19(13):3682-5. PubMed ID: 19450980
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).
    Ye XY; Yoon D; Chen SY; Nayeem A; Golla R; Seethala R; Wang M; Harper T; Sleczka BG; Apedo A; Li YX; He B; Kirby M; Gordon DA; Robl JA
    Bioorg Med Chem Lett; 2014 Jan; 24(2):654-60. PubMed ID: 24360604
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor in the diet-induced obese mice.
    Park JS; Rhee SD; Jung WH; Kang NS; Kim HY; Kang SK; Ahn JH; Kim KY
    Eur J Pharmacol; 2012 Sep; 691(1-3):19-27. PubMed ID: 22760069
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
    Rohde JJ; Pliushchev MA; Sorensen BK; Wodka D; Shuai Q; Wang J; Fung S; Monzon KM; Chiou WJ; Pan L; Deng X; Chovan LE; Ramaiya A; Mullally M; Henry RF; Stolarik DF; Imade HM; Marsh KC; Beno DW; Fey TA; Droz BA; Brune ME; Camp HS; Sham HL; Frevert EU; Jacobson PB; Link JT
    J Med Chem; 2007 Jan; 50(1):149-64. PubMed ID: 17201418
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A novel highly potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, UI-1499.
    Byun SY; Shin YJ; Nam KY; Hong SP; Ahn SK
    Life Sci; 2015 Jan; 120():1-7. PubMed ID: 25447448
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
    Sorensen B; Winn M; Rohde J; Shuai Q; Wang J; Fung S; Monzon K; Chiou W; Stolarik D; Imade H; Pan L; Deng X; Chovan L; Longenecker K; Judge R; Qin W; Brune M; Camp H; Frevert EU; Jacobson P; Link JT
    Bioorg Med Chem Lett; 2007 Jan; 17(2):527-32. PubMed ID: 17070044
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors.
    Sun D; Wang Z; Caille S; DeGraffenreid M; Gonzalez-Lopez de Turiso F; Hungate R; Jaen JC; Jiang B; Julian LD; Kelly R; McMinn DL; Kaizerman J; Rew Y; Sudom A; Tu H; Ursu S; Walker N; Willcockson M; Yan X; Ye Q; Powers JP
    Bioorg Med Chem Lett; 2011 Jan; 21(1):405-10. PubMed ID: 21093258
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11β-hydroxysteroid dehydrogenase type 1.
    Xia G; Liu L; Xue M; Liu H; Yu J; Li P; Chen Q; Xiong B; Liu X; Shen J
    Mol Cell Endocrinol; 2012 Jul; 358(1):46-52. PubMed ID: 22410288
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1.
    Venier O; Pascal C; Braun A; Namane C; Mougenot P; Crespin O; Pacquet F; Mougenot C; Monseau C; Onofri B; Dadji-Faïhun R; Leger C; Ben-Hassine M; Van-Pham T; Ragot JL; Philippo C; Güssregen S; Engel C; Farjot G; Noah L; Maniani K; Nicolaï E
    Bioorg Med Chem Lett; 2011 Apr; 21(8):2244-51. PubMed ID: 21439819
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Recent advances in the discovery of 11beta-HSD1 inhibitors.
    Boyle CD
    Curr Opin Drug Discov Devel; 2008 Jul; 11(4):495-511. PubMed ID: 18600567
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.