BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

292 related articles for article (PubMed ID: 20363126)

  • 21. The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.
    Neelamkavil SF; Boyle CD; Chackalamannil S; Greenlee WJ; Zhang L; Terracina G
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4563-5. PubMed ID: 19625185
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
    Sun D; Wang Z; Di Y; Jaen JC; Labelle M; Ma J; Miao S; Sudom A; Tang L; Tomooka CS; Tu H; Ursu S; Walker N; Yan X; Ye Q; Powers JP
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3513-6. PubMed ID: 18511278
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
    Olson S; Aster SD; Brown K; Carbin L; Graham DW; Hermanowski-Vosatka A; LeGrand CB; Mundt SS; Robbins MA; Schaeffer JM; Slossberg LH; Szymonifka MJ; Thieringer R; Wright SD; Balkovec JM
    Bioorg Med Chem Lett; 2005 Oct; 15(19):4359-62. PubMed ID: 16039856
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.
    Sorensen B; Rohde J; Wang J; Fung S; Monzon K; Chiou W; Pan L; Deng X; Stolarik D; Frevert EU; Jacobson P; Link JT
    Bioorg Med Chem Lett; 2006 Dec; 16(23):5958-62. PubMed ID: 16996734
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction.
    Leiva R; Griñan-Ferré C; Seira C; Valverde E; McBride A; Binnie M; Pérez B; Luque FJ; Pallàs M; Bidon-Chanal A; Webster SP; Vázquez S
    Eur J Med Chem; 2017 Oct; 139():412-428. PubMed ID: 28818766
    [TBL] [Abstract][Full Text] [Related]  

  • 26. HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models.
    Okazaki S; Takahashi T; Iwamura T; Nakaki J; Sekiya Y; Yagi M; Kumagai H; Sato M; Sakami S; Nitta A; Kawai K; Kainoh M
    J Pharmacol Exp Ther; 2014 Oct; 351(1):181-9. PubMed ID: 25100752
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1.
    Su X; Pradaux-Caggiano F; Vicker N; Thomas MP; Halem H; Culler MD; Potter BV
    ChemMedChem; 2011 Sep; 6(9):1616-29. PubMed ID: 21714097
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.
    Patel JR; Shuai Q; Dinges J; Winn M; Pliushchev M; Fung S; Monzon K; Chiou W; Wang J; Pan L; Wagaw S; Engstrom K; Kerdesky FA; Longenecker K; Judge R; Qin W; Imade HM; Stolarik D; Beno DW; Brune M; Chovan LE; Sham HL; Jacobson P; Link JT
    Bioorg Med Chem Lett; 2007 Feb; 17(3):750-5. PubMed ID: 17110106
    [TBL] [Abstract][Full Text] [Related]  

  • 29. 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties.
    Villhauer EB; Brinkman JA; Naderi GB; Burkey BF; Dunning BE; Prasad K; Mangold BL; Russell ME; Hughes TE
    J Med Chem; 2003 Jun; 46(13):2774-89. PubMed ID: 12801240
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Structure-based and property-compliant library design of 11β-HSD1 adamantyl amide inhibitors.
    Paderes GD; Dress K; Huang B; Elleraas J; Rejto PA; Pauly T
    Methods Mol Biol; 2011; 685():191-215. PubMed ID: 20981525
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
    Flyrén K; Bergquist LO; Castro VM; Fotsch C; Johansson L; St Jean DJ; Sutin L; Williams M
    Bioorg Med Chem Lett; 2007 Jun; 17(12):3421-5. PubMed ID: 17442567
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
    Su X; Halem HA; Thomas MP; Moutrille C; Culler MD; Vicker N; Potter BV
    Bioorg Med Chem; 2012 Nov; 20(21):6394-402. PubMed ID: 23040895
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.
    Hult M; Shafqat N; Elleby B; Mitschke D; Svensson S; Forsgren M; Barf T; Vallgårda J; Abrahmsen L; Oppermann U
    Mol Cell Endocrinol; 2006 Mar; 248(1-2):26-33. PubMed ID: 16431016
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species.
    Arampatzis S; Kadereit B; Schuster D; Balazs Z; Schweizer RA; Frey FJ; Langer T; Odermatt A
    J Mol Endocrinol; 2005 Aug; 35(1):89-101. PubMed ID: 16087724
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1.
    Tice CM; Zhao W; Krosky PM; Kruk BA; Berbaum J; Johnson JA; Bukhtiyarov Y; Panemangalore R; Scott BB; Zhao Y; Bruno JG; Howard L; Togias J; Ye YJ; Singh SB; McKeever BM; Lindblom PR; Guo J; Guo R; Nar H; Schuler-Metz A; Gregg RE; Leftheris K; Harrison RK; McGeehan GM; Zhuang L; Claremon DA
    Bioorg Med Chem Lett; 2010 Nov; 20(22):6725-9. PubMed ID: 20864344
    [TBL] [Abstract][Full Text] [Related]  

  • 36. The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors.
    Yan X; Wang Z; Sudom A; Cardozo M; DeGraffenreid M; Di Y; Fan P; He X; Jaen JC; Labelle M; Liu J; Ma J; McMinn D; Miao S; Sun D; Tang L; Tu H; Ursu S; Walker N; Ye Q; Powers JP
    Bioorg Med Chem Lett; 2010 Dec; 20(23):7071-5. PubMed ID: 20971000
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Design and synthesis of (R)-1-arylsulfonylpiperidine-2-carboxamides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
    Xia G; Liu L; Liu H; Yu J; Xu Z; Chen Q; Ma C; Li P; Xiong B; Liu X; Shen J
    ChemMedChem; 2013 Apr; 8(4):577-81. PubMed ID: 23471829
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Novel 11β-HSD1 inhibitors: C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold.
    Leiva R; Seira C; McBride A; Binnie M; Luque FJ; Bidon-Chanal A; Webster SP; Vázquez S
    Bioorg Med Chem Lett; 2015 Oct; 25(19):4250-3. PubMed ID: 26306982
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
    Su X; Vicker N; Ganeshapillai D; Smith A; Purohit A; Reed MJ; Potter BV
    Mol Cell Endocrinol; 2006 Mar; 248(1-2):214-7. PubMed ID: 16325333
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344).
    Park JS; Rhee SD; Kang NS; Jung WH; Kim HY; Kim JH; Kang SK; Cheon HG; Ahn JH; Kim KY
    Biochem Pharmacol; 2011 Apr; 81(8):1028-35. PubMed ID: 21315688
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 15.