BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

242 related articles for article (PubMed ID: 2036355)

  • 1. Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.
    Herschlag D; Piccirilli JA; Cech TR
    Biochemistry; 1991 May; 30(20):4844-54. PubMed ID: 2036355
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site.
    Herschlag D; Cech TR
    Biochemistry; 1990 Nov; 29(44):10159-71. PubMed ID: 2271645
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site.
    Herschlag D; Cech TR
    Biochemistry; 1990 Nov; 29(44):10172-80. PubMed ID: 2271646
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Comparison of pH dependencies of the Tetrahymena ribozyme reactions with RNA 2'-substituted and phosphorothioate substrates reveals a rate-limiting conformational step.
    Herschlag D; Khosla M
    Biochemistry; 1994 May; 33(17):5291-7. PubMed ID: 8172903
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions.
    Liao X; Anjaneyulu PS; Curley JF; Hsu M; Boehringer M; Caruthers MH; Piccirilli JA
    Biochemistry; 2001 Sep; 40(37):10911-26. PubMed ID: 11551186
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evidence for processivity and two-step binding of the RNA substrate from studies of J1/2 mutants of the Tetrahymena ribozyme.
    Herschlag D
    Biochemistry; 1992 Feb; 31(5):1386-99. PubMed ID: 1736996
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA.
    Herschlag D; Eckstein F; Cech TR
    Biochemistry; 1993 Aug; 32(32):8299-311. PubMed ID: 7688572
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu).
    Zaug AJ; Dávila-Aponte JA; Cech TR
    Biochemistry; 1994 Dec; 33(49):14935-47. PubMed ID: 7527660
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
    Yoshida A; Shan So; Herschlag D; Piccirilli JA
    Chem Biol; 2000 Feb; 7(2):85-96. PubMed ID: 10662698
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding.
    McConnell TS; Cech TR; Herschlag D
    Proc Natl Acad Sci U S A; 1993 Sep; 90(18):8362-6. PubMed ID: 8378306
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis.
    Legault P; Herschlag D; Celander DW; Cech TR
    Nucleic Acids Res; 1992 Dec; 20(24):6613-9. PubMed ID: 1480482
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting.
    McSwiggen JA; Cech TR
    Science; 1989 May; 244(4905):679-83. PubMed ID: 2470150
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Fluorescence-detected stopped flow with a pyrene labeled substrate reveals that guanosine facilitates docking of the 5' cleavage site into a high free energy binding mode in the Tetrahymena ribozyme.
    Bevilacqua PC; Li Y; Turner DH
    Biochemistry; 1994 Sep; 33(37):11340-8. PubMed ID: 7727385
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme.
    Lorsch JR; Szostak JW
    Biochemistry; 1995 Nov; 34(46):15315-27. PubMed ID: 7578148
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Probing the role of metal ions in RNA catalysis: kinetic and thermodynamic characterization of a metal ion interaction with the 2'-moiety of the guanosine nucleophile in the Tetrahymena group I ribozyme.
    Shan SO; Herschlag D
    Biochemistry; 1999 Aug; 38(34):10958-75. PubMed ID: 10460151
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A new metal ion interaction in the Tetrahymena ribozyme reaction revealed by double sulfur substitution.
    Yoshida A; Sun S; Piccirilli JA
    Nat Struct Biol; 1999 Apr; 6(4):318-21. PubMed ID: 10201397
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Guanosine binds to the Tetrahymena ribozyme in more than one step, and its 2'-OH and the nonbridging pro-Sp phosphoryl oxygen at the cleavage site are required for productive docking.
    Profenno LA; Kierzek R; Testa SM; Turner DH
    Biochemistry; 1997 Oct; 36(41):12477-85. PubMed ID: 9376352
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction.
    McConnell TS; Herschlag D; Cech TR
    Biochemistry; 1997 Jul; 36(27):8293-303. PubMed ID: 9204875
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
    Herschlag D; Eckstein F; Cech TR
    Biochemistry; 1993 Aug; 32(32):8312-21. PubMed ID: 7688573
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mechanistic investigations of a ribozyme derived from the Tetrahymena group I intron: insights into catalysis and the second step of self-splicing.
    Mei R; Herschlag D
    Biochemistry; 1996 May; 35(18):5796-809. PubMed ID: 8639540
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.