These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

142 related articles for article (PubMed ID: 2036422)

  • 1. Importance of hydrogen-bonding interactions involving the side chain of Asp158 in the catalytic mechanism of papain.
    Ménard R; Khouri HE; Plouffe C; Laflamme P; Dupras R; Vernet T; Tessier DC; Thomas DY; Storer AC
    Biochemistry; 1991 Jun; 30(22):5531-8. PubMed ID: 2036422
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A protein engineering study of the role of aspartate 158 in the catalytic mechanism of papain.
    Ménard R; Khouri HE; Plouffe C; Dupras R; Ripoll D; Vernet T; Tessier DC; Lalberté F; Thomas DY; Storer AC
    Biochemistry; 1990 Jul; 29(28):6706-13. PubMed ID: 2397208
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Removal of an inter-domain hydrogen bond through site-directed mutagenesis: role of serine 176 in the mechanism of papain.
    Ménard R; Plouffe C; Khouri HE; Dupras R; Tessier DC; Vernet T; Thomas DY; Storer AC
    Protein Eng; 1991 Feb; 4(3):307-11. PubMed ID: 1907009
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The double catalytic triad, Cys25-His159-Asp158 and Cys25-His159-Asn175, in papain catalysis: role of Asp158 and Asn175.
    Wang J; Xiang YF; Lim C
    Protein Eng; 1994 Jan; 7(1):75-82. PubMed ID: 8140097
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Engineering of papain: selective alteration of substrate specificity by site-directed mutagenesis.
    Khouri HE; Vernet T; Ménard R; Parlati F; Laflamme P; Tessier DC; Gour-Salin B; Thomas DY; Storer AC
    Biochemistry; 1991 Sep; 30(37):8929-36. PubMed ID: 1892810
    [TBL] [Abstract][Full Text] [Related]  

  • 6. An unequivocal example of cysteine proteinase activity affected by multiple electrostatic interactions.
    Taylor MA; Baker KC; Connerton IF; Cummings NJ; Harris GW; Henderson IM; Jones ST; Pickersgill RW; Sumner IG; Warwicker J
    Protein Eng; 1994 Oct; 7(10):1267-76. PubMed ID: 7855143
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Contribution of the glutamine 19 side chain to transition-state stabilization in the oxyanion hole of papain.
    Ménard R; Carrière J; Laflamme P; Plouffe C; Khouri HE; Vernet T; Tessier DC; Thomas DY; Storer AC
    Biochemistry; 1991 Sep; 30(37):8924-8. PubMed ID: 1892809
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Generation of nucleophilic character in the Cys25/His159 ion pair of papain involves Trp177 but not Asp158.
    Gul S; Hussain S; Thomas MP; Resmini M; Verma CS; Thomas EW; Brocklehurst K
    Biochemistry; 2008 Feb; 47(7):2025-35. PubMed ID: 18225918
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Modification of the electrostatic environment is tolerated in the oxyanion hole of the cysteine protease papain.
    Ménard R; Plouffe C; Laflamme P; Vernet T; Tessier DC; Thomas DY; Storer AC
    Biochemistry; 1995 Jan; 34(2):464-71. PubMed ID: 7819238
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Clarification of the pH-dependent kinetic behaviour of papain by using reactivity probes and analysis of alkylation and catalysed acylation reactions in terms of multihydronic state models: implications for electrostatics calculations and interpretation of the consequences of site-specific mutations such as Asp-158-Asn and Asp-158-Glu.
    Mellor GW; Patel M; Thomas EW; Brocklehurst K
    Biochem J; 1993 Aug; 294 ( Pt 1)(Pt 1):201-10. PubMed ID: 8103322
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The contribution of intermolecular hydrogen bonding to the kinetic specificity of papain.
    Liu S; Hanzlik RP
    Biochim Biophys Acta; 1993 Nov; 1158(3):264-72. PubMed ID: 8251526
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Contribution to activity of histidine-aromatic, amide-aromatic, and aromatic-aromatic interactions in the extended catalytic site of cysteine proteinases.
    Brömme D; Bonneau PR; Purisima E; Lachance P; Hajnik S; Thomas DY; Storer AC
    Biochemistry; 1996 Apr; 35(13):3970-9. PubMed ID: 8672429
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 ion-pair is insufficient for catalytic competence in both chymopapain M and papain.
    Thomas MP; Topham CM; Kowlessur D; Mellor GW; Thomas EW; Whitford D; Brocklehurst K
    Biochem J; 1994 Jun; 300 ( Pt 3)(Pt 3):805-20. PubMed ID: 8010964
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural and functional roles of asparagine 175 in the cysteine protease papain.
    Vernet T; Tessier DC; Chatellier J; Plouffe C; Lee TS; Thomas DY; Storer AC; Ménard R
    J Biol Chem; 1995 Jul; 270(28):16645-52. PubMed ID: 7622473
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Modulation of the enzymatic activity of papain by interdomain residues remote from the active site.
    Altschuh D; Tessier DC; Vernet T
    Protein Eng; 1994 Jun; 7(6):769-75. PubMed ID: 7937707
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Site-directed mutagenesis on (serine) carboxypeptidase Y. A hydrogen bond network stabilizes the transition state by interaction with the C-terminal carboxylate group of the substrate.
    Mortensen UH; Remington SJ; Breddam K
    Biochemistry; 1994 Jan; 33(2):508-17. PubMed ID: 7904479
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Contribution of a buried aspartate residue towards the catalytic efficiency and structural stability of Bacillus stearothermophilus lactate dehydrogenase.
    Nobbs TJ; Cortés A; Gelpi JL; Holbrook JJ; Atkinson T; Scawen MD; Nicholls DJ
    Biochem J; 1994 Jun; 300 ( Pt 2)(Pt 2):491-9. PubMed ID: 8002955
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evidence that the carboxy groups of Asp158 in papain and caricain have abnormally low pKa values and thus do not contribute the key ionisations with pKa 4 that generate catalytic competence.
    Noble M; Abramson D; Verma C; Brocklehurst K
    Biochem Soc Trans; 1997 Feb; 25(1):90S. PubMed ID: 9056988
    [No Abstract]   [Full Text] [Related]  

  • 19. A general framework of cysteine-proteinase mechanism deduced from studies on enzymes with structurally different analogous catalytic-site residues Asp-158 and -161 (papain and actinidin), Gly-196 (cathepsin B) and Asn-165 (cathepsin H). Kinetic studies up to pH 8 of the hydrolysis of N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide catalysed by cathepsin B and of L-arginine 2-naphthylamide catalysed by cathepsin H.
    Willenbrock F; Brocklehurst K
    Biochem J; 1985 Apr; 227(2):521-8. PubMed ID: 3890831
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Probing the function of Asp128 in the lower molecular weight protein-tyrosine phosphatase-catalyzed reaction. A pre-steady-state and steady-state kinetic investigation.
    Wu L; Zhang ZY
    Biochemistry; 1996 Apr; 35(17):5426-34. PubMed ID: 8611532
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.