These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

184 related articles for article (PubMed ID: 20382452)

  • 1. Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.
    Chiang PM; Fortna RR; Price DL; Li T; Wong PC
    Neurobiol Aging; 2012 Feb; 33(2):277-85. PubMed ID: 20382452
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity.
    Zhang X; Sullivan E; Scimeca M; Wu X; Li YM; Sisodia SS
    J Biol Chem; 2016 Mar; 291(13):6748-53. PubMed ID: 26887941
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Toward the structure of presenilin/γ-secretase and presenilin homologs.
    Wolfe MS
    Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
    J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
    Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
    J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
    Steiner H; Winkler E; Haass C
    J Biol Chem; 2008 Dec; 283(50):34677-86. PubMed ID: 18801744
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment.
    Mao G; Cui MZ; Li T; Jin Y; Xu X
    J Neurochem; 2012 Dec; 123(5):837-44. PubMed ID: 22973949
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.
    Futai E; Yagishita S; Ishiura S
    J Biol Chem; 2009 May; 284(19):13013-22. PubMed ID: 19254953
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex.
    Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VM; Doms RW
    J Biol Chem; 2004 Jan; 279(5):3685-93. PubMed ID: 14593096
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.
    Edbauer D; Kaether C; Steiner H; Haass C
    J Biol Chem; 2004 Sep; 279(36):37311-5. PubMed ID: 15210705
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway.
    Spasic D; Raemaekers T; Dillen K; Declerck I; Baert V; Serneels L; Füllekrug J; Annaert W
    J Cell Biol; 2007 Feb; 176(5):629-40. PubMed ID: 17325205
    [TBL] [Abstract][Full Text] [Related]  

  • 12. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
    Cheng H; Vetrivel KS; Drisdel RC; Meckler X; Gong P; Leem JY; Li T; Carter M; Chen Y; Nguyen P; Iwatsubo T; Tomita T; Wong PC; Green WN; Kounnas MZ; Thinakaran G
    J Biol Chem; 2009 Jan; 284(3):1373-84. PubMed ID: 19028695
    [TBL] [Abstract][Full Text] [Related]  

  • 13. APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.
    Gu Y; Chen F; Sanjo N; Kawarai T; Hasegawa H; Duthie M; Li W; Ruan X; Luthra A; Mount HT; Tandon A; Fraser PE; St George-Hyslop P
    J Biol Chem; 2003 Feb; 278(9):7374-80. PubMed ID: 12471034
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
    Li T; Ma G; Cai H; Price DL; Wong PC
    J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex.
    Hu Y; Fortini ME
    J Cell Biol; 2003 May; 161(4):685-90. PubMed ID: 12771124
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Active gamma-secretase complexes contain only one of each component.
    Sato T; Diehl TS; Narayanan S; Funamoto S; Ihara Y; De Strooper B; Steiner H; Haass C; Wolfe MS
    J Biol Chem; 2007 Nov; 282(47):33985-93. PubMed ID: 17911105
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex.
    Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; Lee VM; Doms RW
    J Biol Chem; 2003 Oct; 278(44):43284-91. PubMed ID: 12917438
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-activity relationship of presenilin in γ-secretase-mediated intramembrane cleavage.
    Cai T; Tomita T
    Semin Cell Dev Biol; 2020 Sep; 105():102-109. PubMed ID: 32171519
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1.
    Watanabe N; Tomita T; Sato C; Kitamura T; Morohashi Y; Iwatsubo T
    J Biol Chem; 2005 Dec; 280(51):41967-75. PubMed ID: 16234244
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
    LaVoie MJ; Fraering PC; Ostaszewski BL; Ye W; Kimberly WT; Wolfe MS; Selkoe DJ
    J Biol Chem; 2003 Sep; 278(39):37213-22. PubMed ID: 12857757
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.