130 related articles for article (PubMed ID: 20394422)
1. Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.
McKenna CE; Kashemirov BA; Błazewska KM; Mallard-Favier I; Stewart CA; Rojas J; Lundy MW; Ebetino FH; Baron RA; Dunford JE; Kirsten ML; Seabra MC; Bala JL; Marma MS; Rogers MJ; Coxon FP
J Med Chem; 2010 May; 53(9):3454-64. PubMed ID: 20394422
[TBL] [Abstract][Full Text] [Related]
2. Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo.
Coxon FP; Ebetino FH; Mules EH; Seabra MC; McKenna CE; Rogers MJ
Bone; 2005 Sep; 37(3):349-58. PubMed ID: 16006204
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.
Marma MS; Xia Z; Stewart C; Coxon F; Dunford JE; Baron R; Kashemirov BA; Ebetino FH; Triffitt JT; Russell RG; McKenna CE
J Med Chem; 2007 Nov; 50(24):5967-75. PubMed ID: 17975902
[TBL] [Abstract][Full Text] [Related]
4. Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells.
Roelofs AJ; Hulley PA; Meijer A; Ebetino FH; Russell RG; Shipman CM
Int J Cancer; 2006 Sep; 119(6):1254-61. PubMed ID: 16619218
[TBL] [Abstract][Full Text] [Related]
5. Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors.
Błażewska KM; Ni F; Haiges R; Kashemirov BA; Coxon FP; Stewart CA; Baron R; Rogers MJ; Seabra MC; Ebetino FH; McKenna CE
Eur J Med Chem; 2011 Oct; 46(10):4820-6. PubMed ID: 21889236
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and Biological Evaluation of Imidazole-Bearing α-Phosphonocarboxylates as Inhibitors of Rab Geranylgeranyl Transferase (RGGT).
Joachimiak Ł; Marchwicka A; Gendaszewska-Darmach E; Błażewska KM
ChemMedChem; 2018 Apr; 13(8):842-851. PubMed ID: 29498238
[TBL] [Abstract][Full Text] [Related]
7. Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.
Baron RA; Tavaré R; Figueiredo AC; Błazewska KM; Kashemirov BA; McKenna CE; Ebetino FH; Taylor A; Rogers MJ; Coxon FP; Seabra MC
J Biol Chem; 2009 Mar; 284(11):6861-8. PubMed ID: 19074143
[TBL] [Abstract][Full Text] [Related]
8. Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.
Coxon FP; Helfrich MH; Larijani B; Muzylak M; Dunford JE; Marshall D; McKinnon AD; Nesbitt SA; Horton MA; Seabra MC; Ebetino FH; Rogers MJ
J Biol Chem; 2001 Dec; 276(51):48213-22. PubMed ID: 11581260
[TBL] [Abstract][Full Text] [Related]
9. Identification of the Privileged Position in the Imidazo[1,2-a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors.
Kaźmierczak A; Kusy D; Niinivehmas SP; Gmach J; Joachimiak Ł; Pentikäinen OT; Gendaszewska-Darmach E; Błażewska KM
J Med Chem; 2017 Nov; 60(21):8781-8800. PubMed ID: 28953373
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.
Coxon FP; Joachimiak L; Najumudeen AK; Breen G; Gmach J; Oetken-Lindholm C; Way R; Dunford JE; Abankwa D; Błażewska KM
Eur J Med Chem; 2014 Sep; 84():77-89. PubMed ID: 25016230
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase.
Kusy D; Marchwicka A; Małolepsza J; Justyna K; Gendaszewska-Darmach E; Błażewska KM
Front Chem; 2020; 8():596162. PubMed ID: 33490034
[TBL] [Abstract][Full Text] [Related]
12. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.
Luckman SP; Hughes DE; Coxon FP; Graham R; Russell G; Rogers MJ
J Bone Miner Res; 1998 Apr; 13(4):581-9. PubMed ID: 9556058
[TBL] [Abstract][Full Text] [Related]
13. Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies.
Deprèle S; Kashemirov BA; Hogan JM; Ebetino FH; Barnett BL; Evdokimov A; McKenna CE
Bioorg Med Chem Lett; 2008 May; 18(9):2878-82. PubMed ID: 18434151
[TBL] [Abstract][Full Text] [Related]
14. The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates.
Coxon FP; Taylor A; Stewart CA; Baron R; Seabra MC; Ebetino FH; Rogers MJ
Bone; 2011 Jul; 49(1):111-21. PubMed ID: 21419243
[TBL] [Abstract][Full Text] [Related]
15. Geranylgeranyl transferase type II inhibition prevents myeloma bone disease.
Lawson MA; Coulton L; Ebetino FH; Vanderkerken K; Croucher PI
Biochem Biophys Res Commun; 2008 Dec; 377(2):453-457. PubMed ID: 18929536
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.
Dunford JE; Rogers MJ; Ebetino FH; Phipps RJ; Coxon FP
J Bone Miner Res; 2006 May; 21(5):684-94. PubMed ID: 16734383
[TBL] [Abstract][Full Text] [Related]
17. Molecular targets of the nitrogen containing bisphosphonates: the molecular pharmacology of prenyl synthase inhibition.
Dunford JE
Curr Pharm Des; 2010; 16(27):2961-9. PubMed ID: 20722615
[TBL] [Abstract][Full Text] [Related]
18. Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells.
Coxon FP; Thompson K; Roelofs AJ; Ebetino FH; Rogers MJ
Bone; 2008 May; 42(5):848-60. PubMed ID: 18325866
[TBL] [Abstract][Full Text] [Related]
19. Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase.
Lingham RB; Silverman KC; Jayasuriya H; Kim BM; Amo SE; Wilson FR; Rew DJ; Schaber MD; Bergstrom JD; Koblan KS; Graham SL; Kohl NE; Gibbs JB; Singh SB
J Med Chem; 1998 Nov; 41(23):4492-501. PubMed ID: 9804689
[TBL] [Abstract][Full Text] [Related]
20. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.
Dunford JE; Thompson K; Coxon FP; Luckman SP; Hahn FM; Poulter CD; Ebetino FH; Rogers MJ
J Pharmacol Exp Ther; 2001 Feb; 296(2):235-42. PubMed ID: 11160603
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
