BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

86 related articles for article (PubMed ID: 20400309)

  • 1. 1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.
    Tollefson MB; Acker BA; Jacobsen EJ; Hughes RO; Walker JK; Fox DN; Palmer MJ; Freeman SK; Yu Y; Bond BR
    Bioorg Med Chem Lett; 2010 May; 20(10):3125-8. PubMed ID: 20400309
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.
    Tollefson MB; Acker BA; Jacobsen EJ; Hughes RO; Walker JK; Fox DN; Palmer MJ; Freeman SK; Yu Y; Bond BR
    Bioorg Med Chem Lett; 2010 May; 20(10):3120-4. PubMed ID: 20443228
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors.
    Xia Y; Chackalamannil S; Czarniecki M; Tsai H; Vaccaro H; Cleven R; Cook J; Fawzi A; Watkins R; Zhang H
    J Med Chem; 1997 Dec; 40(26):4372-7. PubMed ID: 9435906
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533).
    Choi H; Lee J; Kim YH; Im DS; Hwang IC; Kim SJ; Moon SK; Lee HW; Lee SS; Ahn SK; Kim SW; Choi NS; Lee KJ
    Bioorg Med Chem Lett; 2010 Jan; 20(1):383-6. PubMed ID: 19906530
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.
    Ahn HS; Bercovici A; Boykow G; Bronnenkant A; Chackalamannil S; Chow J; Cleven R; Cook J; Czarniecki M; Domalski C; Fawzi A; Green M; Gündes A; Ho G; Laudicina M; Lindo N; Ma K; Manna M; McKittrick B; Mirzai B; Nechuta T; Neustadt B; Puchalski C; Pula K; Zhang H
    J Med Chem; 1997 Jul; 40(14):2196-210. PubMed ID: 9216839
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines.
    Traxler P; Bold G; Frei J; Lang M; Lydon N; Mett H; Buchdunger E; Meyer T; Mueller M; Furet P
    J Med Chem; 1997 Oct; 40(22):3601-16. PubMed ID: 9357527
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
    Hughes RO; Walker JK; Rogier DJ; Heasley SE; Blevis-Bal RM; Benson AG; Jacobsen EJ; Cubbage JW; Fobian YM; Owen DR; Freskos JN; Molyneaux JM; Brown DL; Acker BA; Maddux TM; Tollefson MB; Moon JB; Mischke BV; Rumsey JM; Zheng Y; MacInnes A; Bond BR; Yu Y
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5209-13. PubMed ID: 19631533
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A novel series of potent and selective PDE5 inhibitors with potential for high and dose-independent oral bioavailability.
    Allerton CM; Barber CG; Beaumont KC; Brown DG; Cole SM; Ellis D; Lane CA; Maw GN; Mount NM; Rawson DJ; Robinson CM; Street SD; Summerhill NW
    J Med Chem; 2006 Jun; 49(12):3581-94. PubMed ID: 16759100
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and pharmacological evaluations of sildenafil analogues for treatment of erectile dysfunction.
    Flores Toque HA; Priviero FB; Teixeira CE; Perissutti E; Fiorino F; Severino B; Frecentese F; Lorenzetti R; Baracat JS; Santagada V; Caliendo G; Antunes E; De Nucci G
    J Med Chem; 2008 May; 51(9):2807-15. PubMed ID: 18393409
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
    Owen DR; Walker JK; Jon Jacobsen E; Freskos JN; Hughes RO; Brown DL; Bell AS; Brown DG; Phillips C; Mischke BV; Molyneaux JM; Fobian YM; Heasley SE; Moon JB; Stallings WC; Joseph Rogier D; Fox DN; Palmer MJ; Ringer T; Rodriquez-Lens M; Cubbage JW; Blevis-Bal RM; Benson AG; Acker BA; Maddux TM; Tollefson MB; Bond BR; Macinnes A; Yu Y
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4088-91. PubMed ID: 19540112
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.
    Duan H; Zheng J; Lai Q; Liu Z; Tian G; Wang Z; Li J; Shen J
    Bioorg Med Chem Lett; 2009 May; 19(10):2777-9. PubMed ID: 19375311
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 8-(3-chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors.
    Sakamoto T; Koga Y; Hikota M; Matsuki K; Mochida H; Kikkawa K; Fujishige K; Kotera J; Omori K; Morimoto H; Yamada K
    Bioorg Med Chem Lett; 2015 Apr; 25(7):1431-5. PubMed ID: 25754491
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
    Gong X; Wang G; Ren J; Liu Z; Wang Z; Chen T; Yang X; Jiang X; Shen J; Jiang H; Aisa HA; Xu Y; Li J
    Bioorg Med Chem Lett; 2013 Sep; 23(17):4944-7. PubMed ID: 23867165
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction.
    Giovannoni MP; Vergelli C; Biancalani C; Cesari N; Graziano A; Biagini P; Gracia J; Gavaldà A; Dal Piaz V
    J Med Chem; 2006 Aug; 49(17):5363-71. PubMed ID: 16913726
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.
    Yu G; Mason H; Wu X; Wang J; Chong S; Beyer B; Henwood A; Pongrac R; Seliger L; He B; Normandin D; Ferrer P; Zhang R; Adam L; Humphrey WG; Krupinski J; Macor JE
    J Med Chem; 2003 Feb; 46(4):457-60. PubMed ID: 12570368
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design and synthesis of pyrazolo[3,4-d]pyrimidinone derivatives: Discovery of selective phosphodiesterase-5 inhibitors.
    Shaaban MA; Elshaier YAMM; Hammad AH; Farag NA; Hassan Haredy H; AbdEl-Ghany AA; Mohamed KO
    Bioorg Med Chem Lett; 2020 Aug; 30(16):127337. PubMed ID: 32631538
    [TBL] [Abstract][Full Text] [Related]  

  • 17. New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors.
    Feixas J; Giovannoni MP; Vergelli C; Gavaldà A; Cesari N; Graziano A; Dal Piaz V
    Bioorg Med Chem Lett; 2005 May; 15(9):2381-4. PubMed ID: 15837329
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction.
    Kim YH; Choi H; Lee J; Hwang IC; Moon SK; Kim SJ; Lee HW; Im DS; Lee SS; Ahn SK; Kim SW; Han CK; Yoon JH; Lee KJ; Choi NS
    Bioorg Med Chem Lett; 2008 Dec; 18(23):6279-82. PubMed ID: 18976905
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124.
    Dadvar P; O'Flaherty M; Scholten A; Rumpel K; Heck AJ
    Mol Biosyst; 2009 May; 5(5):472-82. PubMed ID: 19381362
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.
    Bi Y; Stoy P; Adam L; He B; Krupinski J; Normandin D; Pongrac R; Seliger L; Watson A; Macor JE
    Bioorg Med Chem Lett; 2004 Mar; 14(6):1577-80. PubMed ID: 15006407
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.