These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

61 related articles for article (PubMed ID: 20405922)

  • 1. Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
    Watterson SH; Xiao Z; Dodd DS; Tortolani DR; Vaccaro W; Potin D; Launay M; Stetsko DK; Skala S; Davis PM; Lee D; Yang X; McIntyre KW; Balimane P; Patel K; Yang Z; Marathe P; Kadiyala P; Tebben AJ; Sheriff S; Chang CY; Ziemba T; Zhang H; Chen BC; DelMonte AJ; Aranibar N; McKinnon M; Barrish JC; Suchard SJ; Murali Dhar TG
    J Med Chem; 2010 May; 53(9):3814-30. PubMed ID: 20405922
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.
    Potin D; Launay M; Monatlik F; Malabre P; Fabreguettes M; Fouquet A; Maillet M; Nicolai E; Dorgeret L; Chevallier F; Besse D; Dufort M; Caussade F; Ahmad SZ; Stetsko DK; Skala S; Davis PM; Balimane P; Patel K; Yang Z; Marathe P; Postelneck J; Townsend RM; Goldfarb V; Sheriff S; Einspahr H; Kish K; Malley MF; DiMarco JD; Gougoutas JZ; Kadiyala P; Cheney DL; Tejwani RW; Murphy DK; Mcintyre KW; Yang X; Chao S; Leith L; Xiao Z; Mathur A; Chen BC; Wu DR; Traeger SC; McKinnon M; Barrish JC; Robl JA; Iwanowicz EJ; Suchard SJ; Dhar TG
    J Med Chem; 2006 Nov; 49(24):6946-9. PubMed ID: 17125246
    [TBL] [Abstract][Full Text] [Related]  

  • 3. De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.
    Potin D; Launay M; Nicolai E; Fabreguette M; Malabre P; Caussade F; Besse D; Skala S; Stetsko DK; Todderud G; Beno BR; Cheney DL; Chang CJ; Sheriff S; Hollenbaugh DL; Barrish JC; Iwanowicz EJ; Suchard SJ; Dhar TG
    Bioorg Med Chem Lett; 2005 Feb; 15(4):1161-4. PubMed ID: 15686933
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A small-molecule antagonist of LFA-1 blocks a conformational change important for LFA-1 function.
    Woska JR; Shih D; Taqueti VR; Hogg N; Kelly TA; Kishimoto TK
    J Leukoc Biol; 2001 Aug; 70(2):329-34. PubMed ID: 11493627
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The leukocyte function-associated antigen-1 (LFA-1)-binding site on ICAM-3 comprises residues on both faces of the first immunoglobulin domain.
    Bell ED; May AP; Simmons DL
    J Immunol; 1998 Aug; 161(3):1363-70. PubMed ID: 9686599
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships.
    Larson RS; Davis T; Bologa C; Semenuk G; Vijayan S; Li Y; Oprea T; Chigaev A; Buranda T; Wagner CR; Sklar LA
    Biochemistry; 2005 Mar; 44(11):4322-31. PubMed ID: 15766261
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Role of LFA-1 and VLA-4 in the adhesion of cloned normal and LFA-1 (CD11/CD18)-deficient T cells to cultured endothelial cells. Indication for a new adhesion pathway.
    Vennegoor CJ; van de Wiel-van Kemenade E; Huijbens RJ; Sanchez-Madrid F; Melief CJ; Figdor CG
    J Immunol; 1992 Feb; 148(4):1093-101. PubMed ID: 1371131
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion.
    Kelly TA; Jeanfavre DD; McNeil DW; Woska JR; Reilly PL; Mainolfi EA; Kishimoto KM; Nabozny GH; Zinter R; Bormann BJ; Rothlein R
    J Immunol; 1999 Nov; 163(10):5173-7. PubMed ID: 10553036
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The determination and correlation of molecular and cellular equilibrium Kd and kinetic k(off) values for small molecule allosteric antagonists of LFA-1.
    Caviness GO; Labadia ME; Giblin PA; Woska JR; Last-Barney K; Jeanfavre DD; Morelock MM
    Biochem Pharmacol; 2007 Jun; 74(1):98-106. PubMed ID: 17482579
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.
    Gadek TR; Burdick DJ; McDowell RS; Stanley MS; Marsters JC; Paris KJ; Oare DA; Reynolds ME; Ladner C; Zioncheck KA; Lee WP; Gribling P; Dennis MS; Skelton NJ; Tumas DB; Clark KR; Keating SM; Beresini MH; Tilley JW; Presta LG; Bodary SC
    Science; 2002 Feb; 295(5557):1086-9. PubMed ID: 11834839
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Humanization of an anti-lymphocyte function-associated antigen (LFA)-1 monoclonal antibody and reengineering of the humanized antibody for binding to rhesus LFA-1.
    Werther WA; Gonzalez TN; O'Connor SJ; McCabe S; Chan B; Hotaling T; Champe M; Fox JA; Jardieu PM; Berman PW; Presta LG
    J Immunol; 1996 Dec; 157(11):4986-95. PubMed ID: 8943405
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CD2/LFA-3 or LFA-1/ICAM-1 but not CD28/B7 interactions can augment cytotoxicity by virus-specific CD8+ cytotoxic T lymphocytes.
    de Waal Malefyt R; Verma S; Bejarano MT; Ranes-Goldberg M; Hill M; Spits H
    Eur J Immunol; 1993 Feb; 23(2):418-24. PubMed ID: 7679643
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
    Suchard SJ; Stetsko DK; Davis PM; Skala S; Potin D; Launay M; Dhar TG; Barrish JC; Susulic V; Shuster DJ; McIntyre KW; McKinnon M; Salter-Cid L
    J Immunol; 2010 Apr; 184(7):3917-26. PubMed ID: 20190141
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off.
    Greenwood J; Wang Y; Calder VL
    Immunology; 1995 Nov; 86(3):408-15. PubMed ID: 8550078
    [TBL] [Abstract][Full Text] [Related]  

  • 15. CD45 mAb induces cell adhesion in peripheral blood mononuclear cells via lymphocyte function-associated antigen-1 (LFA-1) and intercellular cell adhesion molecule 1 (ICAM-1).
    Lorenz HM; Harrer T; Lagoo AS; Baur A; Eger G; Kalden JR
    Cell Immunol; 1993 Mar; 147(1):110-28. PubMed ID: 8096435
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies.
    Tamatani T; Kotani M; Miyasaka M
    Eur J Immunol; 1991 Mar; 21(3):627-33. PubMed ID: 1672643
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dominant-negative effect of the lymphocyte function-associated antigen-1 beta (CD18) cytoplasmic domain on leukocyte adhesion to ICAM-1 and fibronectin.
    Rey-Ladino JA; Pyszniak AM; Takei F
    J Immunol; 1998 Apr; 160(7):3494-501. PubMed ID: 9531311
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The role of CD11a/CD18-CD54 interactions in human T cell-dependent B cell activation.
    Tohma S; Hirohata S; Lipsky PE
    J Immunol; 1991 Jan; 146(2):492-9. PubMed ID: 1670945
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The neuronal glycoprotein telencephalin is a cellular ligand for the CD11a/CD18 leukocyte integrin.
    Tian L; Yoshihara Y; Mizuno T; Mori K; Gahmberg CG
    J Immunol; 1997 Jan; 158(2):928-36. PubMed ID: 8993013
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dynamic control of allosteric antagonism of leukocyte function antigen-1 and intercellular adhesion molecule-1 interaction.
    Nam K; Maiorov V; Feuston B; Kearsley S
    Proteins; 2006 Aug; 64(2):376-84. PubMed ID: 16705652
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.