BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

96 related articles for article (PubMed ID: 20423159)

  • 1. Carbohydrate-based synthetic approach to control toxicity profiles of folate-drug conjugates.
    Vlahov IR; Santhapuram HK; You F; Wang Y; Kleindl PJ; Hahn SJ; Vaughn JF; Reno DS; Leamon CP
    J Org Chem; 2010 Jun; 75(11):3685-91. PubMed ID: 20423159
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.
    Leamon CP; Reddy JA; Klein PJ; Vlahov IR; Dorton R; Bloomfield A; Nelson M; Westrick E; Parker N; Bruna K; Vetzel M; Gehrke M; Nicoson JS; Messmann RA; LoRusso PM; Sausville EA
    J Pharmacol Exp Ther; 2011 Feb; 336(2):336-43. PubMed ID: 20978169
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide.
    Vlahov IR; Santhapuram HK; Kleindl PJ; Howard SJ; Stanford KM; Leamon CP
    Bioorg Med Chem Lett; 2006 Oct; 16(19):5093-6. PubMed ID: 16870437
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation.
    Vlahov IR; You F; Santhapuram HK; Wang Y; Vaughn JF; Hahn SJ; Kleindl PJ; Fan M; Leamon CP
    Bioorg Med Chem Lett; 2011 Feb; 21(4):1202-5. PubMed ID: 21236665
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate.
    Reddy JA; Dorton R; Westrick E; Dawson A; Smith T; Xu LC; Vetzel M; Kleindl P; Vlahov IR; Leamon CP
    Cancer Res; 2007 May; 67(9):4434-42. PubMed ID: 17483358
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and biological evaluation of EC140: a novel folate-targeted vinca alkaloid conjugate.
    Leamon CP; Reddy JA; Vlahov IR; Kleindl PJ; Vetzel M; Westrick E
    Bioconjug Chem; 2006; 17(5):1226-32. PubMed ID: 16984132
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.
    Leamon CP; Vlahov IR; Reddy JA; Vetzel M; Santhapuram HK; You F; Bloomfield A; Dorton R; Nelson M; Kleindl P; Vaughn JF; Westrick E
    Bioconjug Chem; 2014 Mar; 25(3):560-8. PubMed ID: 24564229
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC145 in cancer patients.
    Li J; Sausville EA; Klein PJ; Morgenstern D; Leamon CP; Messmann RA; LoRusso P
    J Clin Pharmacol; 2009 Dec; 49(12):1467-76. PubMed ID: 19837906
    [TBL] [Abstract][Full Text] [Related]  

  • 9. EC-145, a folate-targeted Vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers.
    Dosio F; Milla P; Cattel L
    Curr Opin Investig Drugs; 2010 Dec; 11(12):1424-33. PubMed ID: 21154124
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phase I study of folate conjugate EC145 (Vintafolide) in patients with refractory solid tumors.
    Lorusso PM; Edelman MJ; Bever SL; Forman KM; Pilat M; Quinn MF; Li J; Heath EI; Malburg LM; Klein PJ; Leamon CP; Messmann RA; Sausville EA
    J Clin Oncol; 2012 Nov; 30(32):4011-6. PubMed ID: 23032618
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145.
    Leamon CP; Reddy JA; Vlahov IR; Westrick E; Parker N; Nicoson JS; Vetzel M
    Int J Cancer; 2007 Oct; 121(7):1585-92. PubMed ID: 17551919
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats.
    Chandrasekar D; Sistla R; Ahmad FJ; Khar RK; Diwan PV
    Biomaterials; 2007 Jan; 28(3):504-12. PubMed ID: 16996126
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and NMR structure of linear and cyclic oligomers containing novel furanoid sugar amino acids.
    Gruner SA; Truffault V; Voll G; Locardi E; Stöckle M; Kessler H
    Chemistry; 2002 Oct; 8(19):4365-76. PubMed ID: 12355524
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis, biodistribution, and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates.
    Zhang Y; Sun Y; Xu X; Zhang X; Zhu H; Huang L; Qi Y; Shen YM
    J Med Chem; 2010 Apr; 53(8):3262-72. PubMed ID: 20350006
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Folate coupled poly(ethyleneglycol) conjugates of anionic poly(amidoamine) dendrimer for inflammatory tissue specific drug delivery.
    Chandrasekar D; Sistla R; Ahmad FJ; Khar RK; Diwan PV
    J Biomed Mater Res A; 2007 Jul; 82(1):92-103. PubMed ID: 17269145
    [TBL] [Abstract][Full Text] [Related]  

  • 16. High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide.
    Guertin AD; O'Neil J; Stoeck A; Reddy JA; Cristescu R; Haines BB; Hinton MC; Dorton R; Bloomfield A; Nelson M; Vetzel M; Lejnine S; Nebozhyn M; Zhang T; Loboda A; Picard KL; Schmidt EV; Dussault I; Leamon CP
    Mol Cancer Ther; 2016 Aug; 15(8):1998-2008. PubMed ID: 27256377
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate.
    Tsukamoto T; Haile WH; McGuire JJ; Coward JK
    Arch Biochem Biophys; 1998 Jul; 355(1):109-18. PubMed ID: 9647673
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A synthetic strategy for novel nonsymmetrical bola amphiphiles based on carbohydrates.
    Schuur B; Wagenaar A; Heeres A; Heeres EH
    Carbohydr Res; 2004 Apr; 339(6):1147-53. PubMed ID: 15063204
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vivo structural activity and optimization studies of folate-tubulysin conjugates.
    Reddy JA; Dorton R; Dawson A; Vetzel M; Parker N; Nicoson JS; Westrick E; Klein PJ; Wang Y; Vlahov IR; Leamon CP
    Mol Pharm; 2009; 6(5):1518-25. PubMed ID: 19630399
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pteroyl-gamma-glutamate-cysteine synthesis and its application in folate receptor-mediated cancer cell targeting using folate-tethered liposomes.
    Zhang Y; Guo L; Roeske RW; Antony AC; Jayaram HN
    Anal Biochem; 2004 Sep; 332(1):168-77. PubMed ID: 15301962
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.