121 related articles for article (PubMed ID: 20434437)
1. Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.
Zhang W; Modén O; Mannervik B
Chem Biol Interact; 2010 Jul; 186(2):110-7. PubMed ID: 20434437
[TBL] [Abstract][Full Text] [Related]
2. Divergent activities of human glutathione transferases in the bioactivation of azathioprine.
Eklund BI; Moberg M; Bergquist J; Mannervik B
Mol Pharmacol; 2006 Aug; 70(2):747-54. PubMed ID: 16717136
[TBL] [Abstract][Full Text] [Related]
3. Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.
Kurtovic S; Modén O; Shokeer A; Mannervik B
J Mol Biol; 2008 Feb; 375(5):1365-79. PubMed ID: 18155239
[TBL] [Abstract][Full Text] [Related]
4. Glutathione transferases in the bioactivation of azathioprine.
Modén O; Mannervik B
Adv Cancer Res; 2014; 122():199-244. PubMed ID: 24974183
[TBL] [Abstract][Full Text] [Related]
5. Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.
Eklund BI; Gunnarsdottir S; Elfarra AA; Mannervik B
Biochem Pharmacol; 2007 Jun; 73(11):1829-41. PubMed ID: 17433263
[TBL] [Abstract][Full Text] [Related]
6. Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine.
Modén O; Zhang W; Mannervik B
Protein Eng Des Sel; 2012 Apr; 25(4):189-97. PubMed ID: 22334756
[TBL] [Abstract][Full Text] [Related]
7. Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa.
Srivastava SK; Singhal SS; Hu X; Awasthi YC; Zimniak P; Singh SV
Arch Biochem Biophys; 1999 Jun; 366(1):89-94. PubMed ID: 10334868
[TBL] [Abstract][Full Text] [Related]
8. Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine.
Kurtovic S; Grehn L; Karlsson A; Hellman U; Mannervik B
Anal Biochem; 2008 Apr; 375(2):339-44. PubMed ID: 18211812
[TBL] [Abstract][Full Text] [Related]
9. The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.
Parker LJ; Ciccone S; Italiano LC; Primavera A; Oakley AJ; Morton CJ; Hancock NC; Bello ML; Parker MW
J Mol Biol; 2008 Jun; 380(1):131-44. PubMed ID: 18511072
[TBL] [Abstract][Full Text] [Related]
10. Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs.
Eklund BI; Mannervik B
Biochim Biophys Acta; 2007 Aug; 1770(8):1098-103. PubMed ID: 17493759
[TBL] [Abstract][Full Text] [Related]
11. Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface.
Josephy PD; Pan D; Ianni MD; Mannervik B
Arch Biochem Biophys; 2011 Sep; 513(2):87-93. PubMed ID: 21781954
[TBL] [Abstract][Full Text] [Related]
12. Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine.
Zhang W; Modén O; Tars K; Mannervik B
Chem Biol; 2012 Mar; 19(3):414-21. PubMed ID: 22444596
[TBL] [Abstract][Full Text] [Related]
13. A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes.
Comstock KE; Widersten M; Hao XY; Henner WD; Mannervik B
Arch Biochem Biophys; 1994 Jun; 311(2):487-95. PubMed ID: 8203914
[TBL] [Abstract][Full Text] [Related]
14. Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1.
Widersten M; Björnestedt R; Mannervik B
Biochemistry; 1996 Jun; 35(24):7731-42. PubMed ID: 8672473
[TBL] [Abstract][Full Text] [Related]
15. Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions.
Hansson LO; Widersten M; Mannervik B
Biochemistry; 1997 Sep; 36(37):11252-60. PubMed ID: 9287168
[TBL] [Abstract][Full Text] [Related]
16. A novel quasi-species of glutathione transferase with high activity towards naturally occurring isothiocyanates evolves from promiscuous low-activity variants.
Runarsdottir A; Mannervik B
J Mol Biol; 2010 Aug; 401(3):451-64. PubMed ID: 20600121
[TBL] [Abstract][Full Text] [Related]
17. Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
Gearry RB; Barclay ML
J Gastroenterol Hepatol; 2005 Aug; 20(8):1149-57. PubMed ID: 16048561
[TBL] [Abstract][Full Text] [Related]
18. Experimental conditions affecting functional comparison of highly active glutathione transferases.
Fedulova N; Mannervik B
Anal Biochem; 2011 Jun; 413(1):16-23. PubMed ID: 21295006
[TBL] [Abstract][Full Text] [Related]
19. Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library.
Kurtovic S; Runarsdottir A; Emrén LO; Larsson AK; Mannervik B
Protein Eng Des Sel; 2007 May; 20(5):243-56. PubMed ID: 17468114
[TBL] [Abstract][Full Text] [Related]
20. Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi.
Widersten M; Pearson WR; Engström A; Mannervik B
Biochem J; 1991 Jun; 276 ( Pt 2)(Pt 2):519-24. PubMed ID: 2049077
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
