These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 20439761)

  • 1. Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity.
    Marjanovic J; Chalupska D; Patenode C; Coster A; Arnold E; Ye A; Anesi G; Lu Y; Okun I; Tkachenko S; Haselkorn R; Gornicki P
    Proc Natl Acad Sci U S A; 2010 May; 107(20):9093-8. PubMed ID: 20439761
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals.
    Harwood HJ; Petras SF; Shelly LD; Zaccaro LM; Perry DA; Makowski MR; Hargrove DM; Martin KA; Tracey WR; Chapman JG; Magee WP; Dalvie DK; Soliman VF; Martin WH; Mularski CJ; Eisenbeis SA
    J Biol Chem; 2003 Sep; 278(39):37099-111. PubMed ID: 12842871
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors.
    Chen L; Duan Y; Wei H; Ning H; Bi C; Zhao Y; Qin Y; Li Y
    Expert Opin Investig Drugs; 2019 Oct; 28(10):917-930. PubMed ID: 31430206
    [No Abstract]   [Full Text] [Related]  

  • 4. Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.
    Cheng D; Chu CH; Chen L; Feder JN; Mintier GA; Wu Y; Cook JW; Harpel MR; Locke GA; An Y; Tamura JK
    Protein Expr Purif; 2007 Jan; 51(1):11-21. PubMed ID: 16854592
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibitors of mammalian acetyl-CoA carboxylase.
    Corbett JW; Harwood JH
    Recent Pat Cardiovasc Drug Discov; 2007 Nov; 2(3):162-80. PubMed ID: 18221116
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Expression, purification, and characterization of human acetyl-CoA carboxylase 2.
    Kim KW; Yamane H; Zondlo J; Busby J; Wang M
    Protein Expr Purif; 2007 May; 53(1):16-23. PubMed ID: 17223360
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome.
    Schreurs M; Kuipers F; van der Leij FR
    Obes Rev; 2010 May; 11(5):380-8. PubMed ID: 19694967
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based phosphate assay and a fluorescence polarization-based ADP Assay for high-throughput screening.
    Liu Y; Zalameda L; Kim KW; Wang M; McCarter JD
    Assay Drug Dev Technol; 2007 Apr; 5(2):225-35. PubMed ID: 17477831
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
    Bengtsson C; Blaho S; Saitton DB; Brickmann K; Broddefalk J; Davidsson O; Drmota T; Folmer R; Hallberg K; Hallén S; Hovland R; Isin E; Johannesson P; Kull B; Larsson LO; Löfgren L; Nilsson KE; Noeske T; Oakes N; Plowright AT; Schnecke V; Ståhlberg P; Sörme P; Wan H; Wellner E; Oster L
    Bioorg Med Chem; 2011 May; 19(10):3039-53. PubMed ID: 21515056
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
    Gu YG; Weitzberg M; Clark RF; Xu X; Li Q; Zhang T; Hansen TM; Liu G; Xin Z; Wang X; Wang R; McNally T; Zinker BA; Frevert EU; Camp HS; Beutel BA; Sham HL
    J Med Chem; 2006 Jun; 49(13):3770-3. PubMed ID: 16789734
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.
    Zhao LF; Iwasaki Y; Zhe W; Nishiyama M; Taguchi T; Tsugita M; Kambayashi M; Hashimoto K; Terada Y
    Endocr J; 2010; 57(4):317-24. PubMed ID: 20139635
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal.
    Abu-Elheiga L; Matzuk MM; Kordari P; Oh W; Shaikenov T; Gu Z; Wakil SJ
    Proc Natl Acad Sci U S A; 2005 Aug; 102(34):12011-6. PubMed ID: 16103361
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome.
    Harwood HJ
    Curr Opin Investig Drugs; 2004 Mar; 5(3):283-9. PubMed ID: 15083594
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
    Kim CW; Addy C; Kusunoki J; Anderson NN; Deja S; Fu X; Burgess SC; Li C; Ruddy M; Chakravarthy M; Previs S; Milstein S; Fitzgerald K; Kelley DE; Horton JD
    Cell Metab; 2017 Aug; 26(2):394-406.e6. PubMed ID: 28768177
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
    Harriman G; Greenwood J; Bhat S; Huang X; Wang R; Paul D; Tong L; Saha AK; Westlin WF; Kapeller R; Harwood HJ
    Proc Natl Acad Sci U S A; 2016 Mar; 113(13):E1796-805. PubMed ID: 26976583
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular cloning and gene expression of acc2 from grass carp (Ctenopharyngodon idella) and the regulation of glucose metabolism by ACCs inhibitor.
    Cao M; Li X; Dong L; Wen H; Jiang M; Lu X; Huang F; Tian J
    Mol Biol Rep; 2024 Mar; 51(1):402. PubMed ID: 38456942
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The carboxyltransferase activity of the apicoplast acetyl-CoA carboxylase of Toxoplasma gondii is the target of aryloxyphenoxypropionate inhibitors.
    Jelenska J; Sirikhachornkit A; Haselkorn R; Gornicki P
    J Biol Chem; 2002 Jun; 277(26):23208-15. PubMed ID: 11980900
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors.
    Huang T; Sun J; Wang Q; Gao J; Liu Y
    Molecules; 2015 Sep; 20(9):16221-34. PubMed ID: 26370948
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cells.
    Cordonier EL; Jarecke SK; Hollinger FE; Zempleni J
    Eur J Pharmacol; 2016 Jun; 780():202-8. PubMed ID: 27041646
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Acetyl-CoA carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes.
    Kreuz S; Schoelch C; Thomas L; Rist W; Rippmann JF; Neubauer H
    Diabetes Metab Res Rev; 2009 Sep; 25(6):577-86. PubMed ID: 19618481
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.