BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

354 related articles for article (PubMed ID: 20448203)

  • 1. X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.
    Wang D; Zhu G; Huang X; Lippard SJ
    Proc Natl Acad Sci U S A; 2010 May; 107(21):9584-9. PubMed ID: 20448203
    [TBL] [Abstract][Full Text] [Related]  

  • 2. cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.
    Lovejoy KS; Todd RC; Zhang S; McCormick MS; D'Aquino JA; Reardon JT; Sancar A; Giacomini KM; Lippard SJ
    Proc Natl Acad Sci U S A; 2008 Jul; 105(26):8902-7. PubMed ID: 18579768
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Monofunctional platinum-DNA adducts are strong inhibitors of transcription and substrates for nucleotide excision repair in live mammalian cells.
    Zhu G; Myint M; Ang WH; Song L; Lippard SJ
    Cancer Res; 2012 Feb; 72(3):790-800. PubMed ID: 22180496
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of a monofunctional phenanthriplatin-DNA adduct on RNA polymerase II transcriptional fidelity and translesion synthesis.
    Kellinger MW; Park GY; Chong J; Lippard SJ; Wang D
    J Am Chem Soc; 2013 Sep; 135(35):13054-61. PubMed ID: 23927577
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile.
    Park GY; Wilson JJ; Song Y; Lippard SJ
    Proc Natl Acad Sci U S A; 2012 Jul; 109(30):11987-92. PubMed ID: 22773807
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Spectrum of cellular responses to pyriplatin, a monofunctional cationic antineoplastic platinum(II) compound, in human cancer cells.
    Lovejoy KS; Serova M; Bieche I; Emami S; D'Incalci M; Broggini M; Erba E; Gespach C; Cvitkovic E; Faivre S; Raymond E; Lippard SJ
    Mol Cancer Ther; 2011 Sep; 10(9):1709-19. PubMed ID: 21750216
    [TBL] [Abstract][Full Text] [Related]  

  • 7. DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts.
    Kasparkova J; Novakova O; Farrell N; Brabec V
    Biochemistry; 2003 Jan; 42(3):792-800. PubMed ID: 12534292
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Energetics, conformation, and recognition of DNA duplexes containing a major adduct of an anticancer azolato-bridged dinuclear Pt(II) complex.
    Mlcouskova J; Malina J; Novohradsky V; Kasparkova J; Komeda S; Brabec V
    Biochim Biophys Acta; 2012 Oct; 1820(10):1502-11. PubMed ID: 22683702
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair.
    Kostrhunova H; Malina J; Pickard AJ; Stepankova J; Vojtiskova M; Kasparkova J; Muchova T; Rohlfing ML; Bierbach U; Brabec V
    Mol Pharm; 2011 Oct; 8(5):1941-54. PubMed ID: 21806015
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural and mechanistic studies of polymerase η bypass of phenanthriplatin DNA damage.
    Gregory MT; Park GY; Johnstone TC; Lee YS; Yang W; Lippard SJ
    Proc Natl Acad Sci U S A; 2014 Jun; 111(25):9133-8. PubMed ID: 24927576
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Spontaneous translocation of antitumor oxaliplatin, its enantiomeric analogue, and Cisplatin from one strand to another in double-helical DNA.
    Malina J; Natile G; Brabec V
    Chemistry; 2013 Sep; 19(36):11984-91. PubMed ID: 23873652
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Multiple states of stalled T7 RNA polymerase at DNA lesions generated by platinum anticancer agents.
    Jung Y; Lippard SJ
    J Biol Chem; 2003 Dec; 278(52):52084-92. PubMed ID: 14534300
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Understanding and improving platinum anticancer drugs--phenanthriplatin.
    Johnstone TC; Park GY; Lippard SJ
    Anticancer Res; 2014 Jan; 34(1):471-6. PubMed ID: 24403503
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex.
    Spingler B; Whittington DA; Lippard SJ
    Inorg Chem; 2001 Oct; 40(22):5596-602. PubMed ID: 11599959
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The reaction of a platinated methionine motif of CTR1 with cysteine and histidine is dependent upon the type of precursor platinum complex.
    Ma G; Wu Q; Wu X; Arnesano F; Natile G; Sletten E; Liu Y
    J Inorg Biochem; 2015 Dec; 153():239-246. PubMed ID: 26235215
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Long range 1,4 and 1,6-interstrand cross-links formed by a trinuclear platinum complex. Minor groove preassociation affects kinetics and mechanism of cross-link formation as well as adduct structure.
    Hegmans A; Berners-Price SJ; Davies MS; Thomas DS; Humphreys AS; Farrell N
    J Am Chem Soc; 2004 Feb; 126(7):2166-80. PubMed ID: 14971952
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeting RNA polymerase I transcription machinery in cancer cells by a novel monofunctional platinum-based agent.
    Zhang ZL; Zhao CL; Chen Q; Xu K; Qiao X; Xu JY
    Eur J Med Chem; 2018 Jul; 155():434-444. PubMed ID: 29908438
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Protein interactions with platinum-DNA adducts: from structure to function.
    Chaney SG; Campbell SL; Temple B; Bassett E; Wu Y; Faldu M
    J Inorg Biochem; 2004 Oct; 98(10):1551-9. PubMed ID: 15458816
    [TBL] [Abstract][Full Text] [Related]  

  • 19. DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes.
    Novakova O; Kasparkova J; Malina J; Natile G; Brabec V
    Nucleic Acids Res; 2003 Nov; 31(22):6450-60. PubMed ID: 14602903
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Conformation and recognition of DNA damaged by antitumor cis-dichlorido platinum(II) complex of CDK inhibitor bohemine.
    Novakova O; Liskova B; Vystrcilova J; Suchankova T; Vrana O; Starha P; Travnicek Z; Brabec V
    Eur J Med Chem; 2014 May; 78():54-64. PubMed ID: 24675180
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.