BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

187 related articles for article (PubMed ID: 20452660)

  • 1. Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts.
    Previdi S; Malek A; Albertini V; Riva C; Capella C; Broggini M; Carbone GM; Rohr J; Catapano CV
    Gynecol Oncol; 2010 Aug; 118(2):182-8. PubMed ID: 20452660
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer.
    Malek A; Núñez LE; Magistri M; Brambilla L; Jovic S; Carbone GM; Morís F; Catapano CV
    PLoS One; 2012; 7(4):e35130. PubMed ID: 22545098
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.
    Albertini V; Jain A; Vignati S; Napoli S; Rinaldi A; Kwee I; Nur-e-Alam M; Bergant J; Bertoni F; Carbone GM; Rohr J; Catapano CV
    Nucleic Acids Res; 2006; 34(6):1721-34. PubMed ID: 16571899
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target.
    Remsing LL; Bahadori HR; Carbone GM; McGuffie EM; Catapano CV; Rohr J
    Biochemistry; 2003 Jul; 42(27):8313-24. PubMed ID: 12846580
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.
    Fernández-Guizán A; Mansilla S; Barceló F; Vizcaíno C; Núñez LE; Morís F; González S; Portugal J
    Chem Biol Interact; 2014 Aug; 219():123-32. PubMed ID: 24907531
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.
    Remsing LL; González AM; Nur-e-Alam M; Fernández-Lozano MJ; Braña AF; Rix U; Oliveira MA; Méndez C; Salas JA; Rohr J
    J Am Chem Soc; 2003 May; 125(19):5745-53. PubMed ID: 12733914
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity.
    Scott D; Rohr J; Bae Y
    Int J Nanomedicine; 2011; 6():2757-67. PubMed ID: 22114504
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer.
    Yuan P; Wang L; Wei D; Zhang J; Jia Z; Li Q; Le X; Wang H; Yao J; Xie K
    Cancer; 2007 Dec; 110(12):2682-90. PubMed ID: 17973266
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.
    Gao Y; Jia Z; Kong X; Li Q; Chang DZ; Wei D; Le X; Suyun H; Huang S; Wang L; Xie K
    Cancer Res; 2011 Aug; 71(15):5182-93. PubMed ID: 21673052
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Genome-wide modulation of gene transcription in ovarian carcinoma cells by a new mithramycin analogue.
    Vizcaíno C; Núñez LE; Morís F; Portugal J
    PLoS One; 2014; 9(8):e104687. PubMed ID: 25110883
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity.
    Jia Z; Gao Y; Wang L; Li Q; Zhang J; Le X; Wei D; Yao JC; Chang DZ; Huang S; Xie K
    Cancer Res; 2010 Feb; 70(3):1111-9. PubMed ID: 20086170
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer.
    Choi ES; Nam JS; Jung JY; Cho NP; Cho SD
    Sci Rep; 2014 Nov; 4():7162. PubMed ID: 25418289
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A.
    Jia Z; Zhang J; Wei D; Wang L; Yuan P; Le X; Li Q; Yao J; Xie K
    Cancer Res; 2007 May; 67(10):4878-85. PubMed ID: 17510417
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.
    Hedrick E; Cheng Y; Jin UH; Kim K; Safe S
    Oncotarget; 2016 Apr; 7(16):22245-56. PubMed ID: 26967243
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth.
    Hsu TI; Wang MC; Chen SY; Huang ST; Yeh YM; Su WC; Chang WC; Hung JJ
    Mol Pharmacol; 2012 Dec; 82(6):1115-28. PubMed ID: 22956772
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts.
    Zhao Y; Zhang W; Guo Z; Ma F; Wu Y; Bai Y; Gong W; Chen Y; Cheng T; Zhi F; Zhang Y; Wang J; Jiang B
    Oncol Rep; 2013 Oct; 30(4):1782-92. PubMed ID: 23877322
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models.
    Wang L; Guan X; Zhang J; Jia Z; Wei D; Li Q; Yao J; Xie K
    Int J Oncol; 2008 Jul; 33(1):161-7. PubMed ID: 18575762
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma.
    Tornin J; Martinez-Cruzado L; Santos L; Rodriguez A; Núñez LE; Oro P; Hermosilla MA; Allonca E; Fernández-García MT; Astudillo A; Suarez C; Morís F; Rodriguez R
    Oncotarget; 2016 May; 7(21):30935-50. PubMed ID: 27105533
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The antitumor antibiotic mithramycin: new advanced approaches in modification and production.
    Kormanec J; Novakova R; Csolleiova D; Feckova L; Rezuchova B; Sevcikova B; Homerova D
    Appl Microbiol Biotechnol; 2020 Sep; 104(18):7701-7721. PubMed ID: 32686008
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells.
    Rao M; Atay SM; Shukla V; Hong Y; Upham T; Ripley RT; Hong JA; Zhang M; Reardon E; Fetsch P; Miettinen M; Li X; Peer CJ; Sissung T; Figg WD; De Rienzo A; Bueno R; Schrump DS
    Clin Cancer Res; 2016 Mar; 22(5):1197-210. PubMed ID: 26459178
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.