212 related articles for article (PubMed ID: 20455082)
1. BACE1 gene promoter single-nucleotide polymorphisms in Alzheimer's disease.
Zhou W; Cai F; Li Y; Yang GS; O'Connor KD; Holt RA; Song W
J Mol Neurosci; 2010 Sep; 42(1):127-33. PubMed ID: 20455082
[TBL] [Abstract][Full Text] [Related]
2. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
[TBL] [Abstract][Full Text] [Related]
3. Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer's disease.
Sun X; Bromley-Brits K; Song W
J Neurochem; 2012 Jan; 120 Suppl 1():62-70. PubMed ID: 22122349
[TBL] [Abstract][Full Text] [Related]
4. Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.
Sun X; Wang Y; Qing H; Christensen MA; Liu Y; Zhou W; Tong Y; Xiao C; Huang Y; Zhang S; Liu X; Song W
FASEB J; 2005 May; 19(7):739-49. PubMed ID: 15857888
[TBL] [Abstract][Full Text] [Related]
5. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.
Zhao J; Fu Y; Yasvoina M; Shao P; Hitt B; O'Connor T; Logan S; Maus E; Citron M; Berry R; Binder L; Vassar R
J Neurosci; 2007 Apr; 27(14):3639-49. PubMed ID: 17409228
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.
Ly PT; Wu Y; Zou H; Wang R; Zhou W; Kinoshita A; Zhang M; Yang Y; Cai F; Woodgett J; Song W
J Clin Invest; 2013 Jan; 123(1):224-35. PubMed ID: 23202730
[TBL] [Abstract][Full Text] [Related]
7. BACE1: the beta-secretase enzyme in Alzheimer's disease.
Vassar R
J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
[TBL] [Abstract][Full Text] [Related]
8. Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.
Chen CH; Zhou W; Liu S; Deng Y; Cai F; Tone M; Tone Y; Tong Y; Song W
Int J Neuropsychopharmacol; 2012 Feb; 15(1):77-90. PubMed ID: 21329555
[TBL] [Abstract][Full Text] [Related]
9. BAG-1M co-activates BACE1 transcription through NF-κB and accelerates Aβ production and memory deficit in Alzheimer's disease mouse model.
Shi Z; Hong Y; Zhang K; Wang J; Zheng L; Zhang Z; Hu Z; Han X; Han Y; Chen T; Yao Q; Cui H; Hong W
Biochim Biophys Acta Mol Basis Dis; 2017 Sep; 1863(9):2398-2407. PubMed ID: 28502705
[TBL] [Abstract][Full Text] [Related]
10. MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects.
Long JM; Ray B; Lahiri DK
J Biol Chem; 2014 Feb; 289(8):5184-98. PubMed ID: 24352696
[TBL] [Abstract][Full Text] [Related]
11. The beta-secretase, BACE: a prime drug target for Alzheimer's disease.
Vassar R
J Mol Neurosci; 2001 Oct; 17(2):157-70. PubMed ID: 11816789
[TBL] [Abstract][Full Text] [Related]
12. BACE1 polymorphisms do not influence platelet membrane beta-secretase activity or genetic susceptibility for Alzheimer's disease in the Northern Irish population.
Todd S; McKnight AJ; Liu WW; Carson R; Heggarty S; McGuinness B; Irvine GB; Craig D; Passmore AP; Johnston JA
Neuromolecular Med; 2008; 10(4):368-76. PubMed ID: 18581272
[TBL] [Abstract][Full Text] [Related]
13. BACE1 gene promoter is differentially regulated: detection of a novel promoter region for its cell type-specific regulation.
Lahiri DK; Maloney B; Ge YW
J Mol Neurosci; 2006; 28(2):193-210. PubMed ID: 16679558
[TBL] [Abstract][Full Text] [Related]
14. Transcriptional regulation of BACE1 by NFAT3 leads to enhanced amyloidogenic processing.
Mei Z; Yan P; Tan X; Zheng S; Situ B
Neurochem Res; 2015 Apr; 40(4):829-36. PubMed ID: 25663301
[TBL] [Abstract][Full Text] [Related]
15. Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression.
Sun X; He G; Qing H; Zhou W; Dobie F; Cai F; Staufenbiel M; Huang LE; Song W
Proc Natl Acad Sci U S A; 2006 Dec; 103(49):18727-32. PubMed ID: 17121991
[TBL] [Abstract][Full Text] [Related]
16. The normal and pathologic roles of the Alzheimer's β-secretase, BACE1.
Kandalepas PC; Vassar R
Curr Alzheimer Res; 2014; 11(5):441-9. PubMed ID: 24893886
[TBL] [Abstract][Full Text] [Related]
17. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
Kimura A; Hata S; Suzuki T
J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
[TBL] [Abstract][Full Text] [Related]
18. Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.
Christensen MA; Zhou W; Qing H; Lehman A; Philipsen S; Song W
Mol Cell Biol; 2004 Jan; 24(2):865-74. PubMed ID: 14701757
[TBL] [Abstract][Full Text] [Related]
19. Beta-secretase (BACE) as a drug target for Alzheimer's disease.
Vassar R
Adv Drug Deliv Rev; 2002 Dec; 54(12):1589-602. PubMed ID: 12453676
[TBL] [Abstract][Full Text] [Related]
20. BACE1 structure and function in health and Alzheimer's disease.
Cole SL; Vassar R
Curr Alzheimer Res; 2008 Apr; 5(2):100-20. PubMed ID: 18393796
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
