BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

314 related articles for article (PubMed ID: 20456003)

  • 1. Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer's disease.
    Ryu YS; Park SY; Jung MS; Yoon SH; Kwen MY; Lee SY; Choi SH; Radnaabazar C; Kim MK; Kim H; Kim K; Song WJ; Chung SH
    J Neurochem; 2010 Nov; 115(3):574-84. PubMed ID: 20456003
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease.
    Ryoo SR; Cho HJ; Lee HW; Jeong HK; Radnaabazar C; Kim YS; Kim MJ; Son MY; Seo H; Chung SH; Song WJ
    J Neurochem; 2008 Mar; 104(5):1333-44. PubMed ID: 18005339
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models.
    Ferrer I; Barrachina M; Puig B; Martínez de Lagrán M; Martí E; Avila J; Dierssen M
    Neurobiol Dis; 2005 Nov; 20(2):392-400. PubMed ID: 16242644
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
    Kimura R; Kamino K; Yamamoto M; Nuripa A; Kida T; Kazui H; Hashimoto R; Tanaka T; Kudo T; Yamagata H; Tabara Y; Miki T; Akatsu H; Kosaka K; Funakoshi E; Nishitomi K; Sakaguchi G; Kato A; Hattori H; Uema T; Takeda M
    Hum Mol Genet; 2007 Jan; 16(1):15-23. PubMed ID: 17135279
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.
    Coutadeur S; Benyamine H; Delalonde L; de Oliveira C; Leblond B; Foucourt A; Besson T; Casagrande AS; Taverne T; Girard A; Pando MP; Désiré L
    J Neurochem; 2015 May; 133(3):440-51. PubMed ID: 25556849
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts.
    Kawakubo T; Mori R; Shirotani K; Iwata N; Asai M
    Biol Pharm Bull; 2017; 40(3):327-333. PubMed ID: 28250274
    [TBL] [Abstract][Full Text] [Related]  

  • 7. [Elucidating Pathogenic Mechanisms of Early-onset Alzheimer's Disease in Down Syndrome Patients].
    Asai M; Kawakubo T; Mori R; Iwata N
    Yakugaku Zasshi; 2017; 137(7):801-805. PubMed ID: 28674290
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome.
    Park J; Yang EJ; Yoon JH; Chung KC
    Mol Cell Neurosci; 2007 Oct; 36(2):270-9. PubMed ID: 17720532
    [TBL] [Abstract][Full Text] [Related]  

  • 9. PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity.
    Aoyagi N; Uemura K; Kuzuya A; Kihara T; Kawamata J; Shimohama S; Kinoshita A; Takahashi R
    Biochem Biophys Res Commun; 2010 Jan; 391(2):1240-5. PubMed ID: 20006583
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.
    Park JH; Jung MS; Kim YS; Song WJ; Chung SH
    J Neurochem; 2012 Sep; 122(5):1081-91. PubMed ID: 22765017
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
    Kuzuya A; Uemura K; Kitagawa N; Aoyagi N; Kihara T; Ninomiya H; Ishiura S; Takahashi R; Shimohama S
    J Neurosci Res; 2007 Jan; 85(1):153-65. PubMed ID: 17075903
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
    Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
    J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.
    Hijazi M; Fillat C; Medina JM; Velasco A
    Exp Neurol; 2013 Jan; 239():229-34. PubMed ID: 23124096
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.
    Toiber D; Azkona G; Ben-Ari S; Torán N; Soreq H; Dierssen M
    Neurobiol Dis; 2010 Oct; 40(1):348-59. PubMed ID: 20600907
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease.
    Liu K; Solano I; Mann D; Lemere C; Mercken M; Trojanowski JQ; Lee VM
    Acta Neuropathol; 2006 Aug; 112(2):163-74. PubMed ID: 16865398
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes.
    García-Cerro S; Rueda N; Vidal V; Lantigua S; Martínez-Cué C
    Neurobiol Dis; 2017 Oct; 106():76-88. PubMed ID: 28647555
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
    Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling.
    Maesako M; Uemura K; Kuzuya A; Sasaki K; Asada M; Watanabe K; Ando K; Kubota M; Akiyama H; Takahashi R; Kihara T; Shimohama S; Kinoshita A
    J Neurochem; 2012 Jun; 121(6):964-73. PubMed ID: 22443192
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Bidirectional regulation of Aβ levels by Presenilin 1.
    Bustos V; Pulina MV; Kelahmetoglu Y; Sinha SC; Gorelick FS; Flajolet M; Greengard P
    Proc Natl Acad Sci U S A; 2017 Jul; 114(27):7142-7147. PubMed ID: 28533411
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.