BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

267 related articles for article (PubMed ID: 20457604)

  • 1. The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities.
    Cheng Q; Antholine WE; Myers JM; Kalyanaraman B; Arnér ES; Myers CR
    J Biol Chem; 2010 Jul; 285(28):21708-23. PubMed ID: 20457604
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification and conformer analysis of a novel redox-active motif, Pro-Ala-Ser-Cys-Cys-Ser, in Drosophila thioredoxin reductase by semiempirical molecular orbital calculation.
    Kuwahara M; Tamura T; Kawamura K; Inagaki K
    Biosci Biotechnol Biochem; 2011; 75(3):516-21. PubMed ID: 21389620
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selenium as an electron acceptor during the catalytic mechanism of thioredoxin reductase.
    Lothrop AP; Snider GW; Ruggles EL; Patel AS; Lees WJ; Hondal RJ
    Biochemistry; 2014 Feb; 53(4):654-63. PubMed ID: 24422500
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity.
    Lee SR; Bar-Noy S; Kwon J; Levine RL; Stadtman TC; Rhee SG
    Proc Natl Acad Sci U S A; 2000 Mar; 97(6):2521-6. PubMed ID: 10688911
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighboring cysteine residue.
    Nordberg J; Zhong L; Holmgren A; Arnér ES
    J Biol Chem; 1998 May; 273(18):10835-42. PubMed ID: 9556556
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence.
    Zhong L; Arnér ES; Holmgren A
    Proc Natl Acad Sci U S A; 2000 May; 97(11):5854-9. PubMed ID: 10801974
    [TBL] [Abstract][Full Text] [Related]  

  • 7. No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue.
    Lothrop AP; Ruggles EL; Hondal RJ
    Biochemistry; 2009 Jul; 48(26):6213-23. PubMed ID: 19366212
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations.
    Zhong L; Holmgren A
    J Biol Chem; 2000 Jun; 275(24):18121-8. PubMed ID: 10849437
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity.
    Fang J; Lu J; Holmgren A
    J Biol Chem; 2005 Jul; 280(26):25284-90. PubMed ID: 15879598
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The thioredoxin antioxidant system.
    Lu J; Holmgren A
    Free Radic Biol Med; 2014 Jan; 66():75-87. PubMed ID: 23899494
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate.
    Zhang H; Cao D; Cui W; Ji M; Qian X; Zhong L
    Free Radic Biol Med; 2010 Dec; 49(12):2010-8. PubMed ID: 20951799
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The mechanism of high Mr thioredoxin reductase from Drosophila melanogaster.
    Bauer H; Massey V; Arscott LD; Schirmer RH; Ballou DP; Williams CH
    J Biol Chem; 2003 Aug; 278(35):33020-8. PubMed ID: 12816954
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities.
    Xu J; Cheng Q; Arnér ES
    Free Radic Biol Med; 2016 May; 94():110-20. PubMed ID: 26898501
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo.
    Fang J; Holmgren A
    J Am Chem Soc; 2006 Feb; 128(6):1879-85. PubMed ID: 16464088
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Studies of an active site mutant of the selenoprotein thioredoxin reductase: the Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme.
    Johansson L; Arscott LD; Ballou DP; Williams CH; Arnér ES
    Free Radic Biol Med; 2006 Aug; 41(4):649-56. PubMed ID: 16863998
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Can Selenoenzymes Resist Electrophilic Modification? Evidence from Thioredoxin Reductase and a Mutant Containing α-Methylselenocysteine.
    Ste Marie EJ; Wehrle RJ; Haupt DJ; Wood NB; van der Vliet A; Previs MJ; Masterson DS; Hondal RJ
    Biochemistry; 2020 Sep; 59(36):3300-3315. PubMed ID: 32845139
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effectors of thioredoxin reductase: Brevetoxins and manumycin-A.
    Tuladhar A; Hondal RJ; Colon R; Hernandez EL; Rein KS
    Comp Biochem Physiol C Toxicol Pharmacol; 2019 Mar; 217():76-86. PubMed ID: 30476593
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme.
    Sandalova T; Zhong L; Lindqvist Y; Holmgren A; Schneider G
    Proc Natl Acad Sci U S A; 2001 Aug; 98(17):9533-8. PubMed ID: 11481439
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Thioredoxin and thioredoxin reductase control tissue factor activity by thiol redox-dependent mechanism.
    Wang P; Wu Y; Li X; Ma X; Zhong L
    J Biol Chem; 2013 Feb; 288(5):3346-58. PubMed ID: 23223577
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Investigation of the C-terminal redox center of high-Mr thioredoxin reductase by protein engineering and semisynthesis.
    Eckenroth BE; Lacey BM; Lothrop AP; Harris KM; Hondal RJ
    Biochemistry; 2007 Aug; 46(33):9472-83. PubMed ID: 17661444
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.