BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

468 related articles for article (PubMed ID: 20458013)

  • 1. Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging.
    Ragnauth CD; Warren DT; Liu Y; McNair R; Tajsic T; Figg N; Shroff R; Skepper J; Shanahan CM
    Circulation; 2010 May; 121(20):2200-10. PubMed ID: 20458013
    [TBL] [Abstract][Full Text] [Related]  

  • 2. LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation.
    Afonso P; Auclair M; Boccara F; Vantyghem MC; Katlama C; Capeau J; Vigouroux C; Caron-Debarle M
    Atherosclerosis; 2016 Feb; 245():200-11. PubMed ID: 26724531
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells.
    Liu Y; Drozdov I; Shroff R; Beltran LE; Shanahan CM
    Circ Res; 2013 May; 112(10):e99-109. PubMed ID: 23564641
    [TBL] [Abstract][Full Text] [Related]  

  • 4. RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A: implications for Hutchinson-Gilford progeria syndrome.
    Gruber J; Lampe T; Osborn M; Weber K
    J Cell Sci; 2005 Feb; 118(Pt 4):689-96. PubMed ID: 15671064
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress.
    Muteliefu G; Shimizu H; Enomoto A; Nishijima F; Takahashi M; Niwa T
    Am J Physiol Cell Physiol; 2012 Jul; 303(2):C126-34. PubMed ID: 22555846
    [TBL] [Abstract][Full Text] [Related]  

  • 6. HP1α mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells.
    Liu J; Yin X; Liu B; Zheng H; Zhou G; Gong L; Li M; Li X; Wang Y; Hu J; Krishnan V; Zhou Z; Wang Z
    Cell Cycle; 2014; 13(8):1237-47. PubMed ID: 24584199
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B.
    Odinammadu KO; Shilagardi K; Tuminelli K; Judge DP; Gordon LB; Michaelis S
    Nucleus; 2023 Dec; 14(1):2288476. PubMed ID: 38050983
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice.
    Krishnan V; Chow MZ; Wang Z; Zhang L; Liu B; Liu X; Zhou Z
    Proc Natl Acad Sci U S A; 2011 Jul; 108(30):12325-30. PubMed ID: 21746928
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice.
    Fong LG; Ng JK; Meta M; Coté N; Yang SH; Stewart CL; Sullivan T; Burghardt A; Majumdar S; Reue K; Bergo MO; Young SG
    Proc Natl Acad Sci U S A; 2004 Dec; 101(52):18111-6. PubMed ID: 15608054
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Lipodystrophy-linked LMNA p.R482W mutation induces clinical early atherosclerosis and in vitro endothelial dysfunction.
    Bidault G; Garcia M; Vantyghem MC; Ducluzeau PH; Morichon R; Thiyagarajah K; Moritz S; Capeau J; Vigouroux C; Béréziat V
    Arterioscler Thromb Vasc Biol; 2013 Sep; 33(9):2162-71. PubMed ID: 23846499
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes.
    Toth JI; Yang SH; Qiao X; Beigneux AP; Gelb MH; Moulson CL; Miner JH; Young SG; Fong LG
    Proc Natl Acad Sci U S A; 2005 Sep; 102(36):12873-8. PubMed ID: 16129834
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates.
    Sieprath T; Corne TD; Nooteboom M; Grootaert C; Rajkovic A; Buysschaert B; Robijns J; Broers JL; Ramaekers FC; Koopman WJ; Willems PH; De Vos WH
    Nucleus; 2015; 6(3):236-46. PubMed ID: 25996284
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prelamin A and ZMPSTE24 in premature and physiological aging.
    Worman HJ; Michaelis S
    Nucleus; 2023 Dec; 14(1):2270345. PubMed ID: 37885131
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice.
    Wang Y; Shilagardi K; Hsu T; Odinammadu KO; Maruyama T; Wu W; Lin CS; Damoci CB; Spear ED; Shin JY; Hsu W; Michaelis S; Worman HJ
    Proc Natl Acad Sci U S A; 2022 Mar; 119(9):. PubMed ID: 35197292
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence.
    Caron M; Auclair M; Donadille B; Béréziat V; Guerci B; Laville M; Narbonne H; Bodemer C; Lascols O; Capeau J; Vigouroux C
    Cell Death Differ; 2007 Oct; 14(10):1759-67. PubMed ID: 17612587
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome.
    Hamczyk MR; Villa-Bellosta R; Gonzalo P; Andrés-Manzano MJ; Nogales P; Bentzon JF; López-Otín C; Andrés V
    Circulation; 2018 Jul; 138(3):266-282. PubMed ID: 29490993
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing.
    Warren DT; Tajsic T; Porter LJ; Minaisah RM; Cobb A; Jacob A; Rajgor D; Zhang QP; Shanahan CM
    Cell Death Differ; 2015 Sep; 22(9):1540-50. PubMed ID: 25744025
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Genomic instability in laminopathy-based premature aging.
    Liu B; Wang J; Chan KM; Tjia WM; Deng W; Guan X; Huang JD; Li KM; Chau PY; Chen DJ; Pei D; Pendas AM; Cadiñanos J; López-Otín C; Tse HF; Hutchison C; Chen J; Cao Y; Cheah KS; Tryggvason K; Zhou Z
    Nat Med; 2005 Jul; 11(7):780-5. PubMed ID: 15980864
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome.
    Mallampalli MP; Huyer G; Bendale P; Gelb MH; Michaelis S
    Proc Natl Acad Sci U S A; 2005 Oct; 102(40):14416-21. PubMed ID: 16186497
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Prelamin A accumulation in endothelial cells induces premature senescence and functional impairment.
    Bonello-Palot N; Simoncini S; Robert S; Bourgeois P; Sabatier F; Levy N; Dignat-George F; Badens C
    Atherosclerosis; 2014 Nov; 237(1):45-52. PubMed ID: 25200614
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 24.