88 related articles for article (PubMed ID: 20462211)
1. Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).
O'Neill DJ; Adedoyin A; Alfinito PD; Bray JA; Cosmi S; Deecher DC; Fensome A; Harrison J; Leventhal L; Mann C; McComas CC; Sullivan NR; Spangler TB; Uveges AJ; Trybulski EJ; Whiteside GT; Zhang P
J Med Chem; 2010 Jun; 53(11):4511-21. PubMed ID: 20462211
[TBL] [Abstract][Full Text] [Related]
2. Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).
O'Neill DJ; Adedoyin A; Bray JA; Deecher DC; Fensome A; Goldberg JA; Harrison J; Leventhal L; Mann C; Mark L; Nogle L; Sullivan NR; Spangler TB; Terefenko EA; Trybulski EJ; Uveges AJ; Vu A; Whiteside GT; Zhang P
J Med Chem; 2011 Oct; 54(19):6824-31. PubMed ID: 21916421
[TBL] [Abstract][Full Text] [Related]
3. 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.
Zhang P; Terefenko EA; Bray J; Deecher D; Fensome A; Harrison J; Kim C; Koury E; Mark L; McComas CC; Mugford CA; Trybulski EJ; Vu AT; Whiteside GT; Mahaney PE
J Med Chem; 2009 Sep; 52(18):5703-11. PubMed ID: 19722525
[TBL] [Abstract][Full Text] [Related]
4. 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
Vu AT; Cohn ST; Zhang P; Kim CY; Mahaney PE; Bray JA; Johnston GH; Koury EJ; Cosmi SA; Deecher DC; Smith VA; Harrison JE; Leventhal L; Whiteside GT; Kennedy JD; Trybulski EJ
J Med Chem; 2010 Mar; 53(5):2051-62. PubMed ID: 20131864
[TBL] [Abstract][Full Text] [Related]
5. Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites.
Zhou J; Zhang A; Kläss T; Johnson KM; Wang CZ; Ye YP; Kozikowski AP
J Med Chem; 2003 May; 46(10):1997-2007. PubMed ID: 12723962
[TBL] [Abstract][Full Text] [Related]
6. Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.
Fensome A; Goldberg J; McComas CC; Trybulski EJ; Woodworth RP; Deecher DC; Whiteside GT; Zhang P
Bioorg Med Chem Lett; 2010 Mar; 20(5):1555-8. PubMed ID: 20153188
[TBL] [Abstract][Full Text] [Related]
7. Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
Mahaney PE; Gavrin LK; Trybulski EJ; Stack GP; Vu TA; Cohn ST; Ye F; Belardi JK; Santilli AA; Sabatucci JP; Leiter J; Johnston GH; Bray JA; Burroughs KD; Cosmi SA; Leventhal L; Koury EJ; Zhang Y; Mugford CA; Ho DM; Rosenzweig-Lipson SJ; Platt B; Smith VA; Deecher DC
J Med Chem; 2008 Jul; 51(13):4038-49. PubMed ID: 18557608
[TBL] [Abstract][Full Text] [Related]
8. 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.
Micheli F; Cavanni P; Andreotti D; Arban R; Benedetti R; Bertani B; Bettati M; Bettelini L; Bonanomi G; Braggio S; Carletti R; Checchia A; Corsi M; Fazzolari E; Fontana S; Marchioro C; Merlo-Pich E; Negri M; Oliosi B; Ratti E; Read KD; Roscic M; Sartori I; Spada S; Tedesco G; Tarsi L; Terreni S; Visentini F; Zocchi A; Zonzini L; Di Fabio R
J Med Chem; 2010 Jul; 53(13):4989-5001. PubMed ID: 20527970
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.
Zhang P; Terefenko EA; McComas CC; Mahaney PE; Vu A; Trybulski E; Koury E; Johnston G; Bray J; Deecher D
Bioorg Med Chem Lett; 2008 Dec; 18(23):6067-70. PubMed ID: 18951020
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.
Lee KH; Park CE; Min KH; Shin YJ; Chung CM; Kim HH; Yoon HJ; Won-Kim ; Ryu EJ; Shin YJ; Nam HS; Cho JW; Lee HY
Bioorg Med Chem Lett; 2010 Sep; 20(18):5567-71. PubMed ID: 20724153
[TBL] [Abstract][Full Text] [Related]
11. Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.
Kim CY; Mahaney PE; McConnell O; Zhang Y; Manas E; Ho DM; Deecher DC; Trybulski EJ
Bioorg Med Chem Lett; 2009 Sep; 19(17):5029-32. PubMed ID: 19632110
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
McComas CC; Vu AT; Mahaney PE; Cohn ST; Fensome A; Marella MA; Nogle L; Trybulski EJ; Ye F; Zhang P; Alfinito P; Bray J; Johnston G; Koury E; Deecher DC
Bioorg Med Chem Lett; 2008 Sep; 18(18):4929-31. PubMed ID: 18771916
[TBL] [Abstract][Full Text] [Related]
13. Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists.
Gray DL; Xu W; Campbell BM; Dounay AB; Barta N; Boroski S; Denny L; Evans L; Stratman N; Probert A
Bioorg Med Chem Lett; 2009 Dec; 19(23):6604-7. PubMed ID: 19854053
[TBL] [Abstract][Full Text] [Related]
14. Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.
Sabatucci JP; Mahaney PE; Leiter J; Johnston G; Burroughs K; Cosmi S; Zhang Y; Ho D; Deecher DC; Trybulski E
Bioorg Med Chem Lett; 2010 May; 20(9):2809-12. PubMed ID: 20378347
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.
Pontillo J; Wu D; Ching B; Hudson S; Genicot MJ; Gao Y; Ewing T; Fleck BA; Gogas K; Aparicio A; Wang H; Wen J; Wade WS
Bioorg Med Chem Lett; 2008 Dec; 18(23):6151-5. PubMed ID: 18954981
[TBL] [Abstract][Full Text] [Related]
16. 2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression.
Carter DS; Cai HY; Lee EK; Iyer PS; Lucas MC; Roetz R; Schoenfeld RC; Weikert RJ
Bioorg Med Chem Lett; 2010 Jul; 20(13):3941-5. PubMed ID: 20570146
[TBL] [Abstract][Full Text] [Related]
17. 1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase.
Combrink KD; Gülgeze HB; Meanwell NA; Pearce BC; Zulan P; Bisacchi GS; Roberts DG; Stanley P; Seiler SM
J Med Chem; 1998 Nov; 41(24):4854-60. PubMed ID: 9822554
[TBL] [Abstract][Full Text] [Related]
18. Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.
Heffernan GD; Coghlan RD; Manas ES; McDevitt RE; Li Y; Mahaney PE; Robichaud AJ; Huselton C; Alfinito P; Bray JA; Cosmi SA; Johnston GH; Kenney T; Koury E; Winneker RC; Deecher DC; Trybulski EJ
Bioorg Med Chem; 2009 Nov; 17(22):7802-15. PubMed ID: 19836247
[TBL] [Abstract][Full Text] [Related]
19. 1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors.
Beadle CD; Boot J; Camp NP; Dezutter N; Findlay J; Hayhurst L; Masters JJ; Penariol R; Walter MW
Bioorg Med Chem Lett; 2005 Oct; 15(20):4432-7. PubMed ID: 16137883
[TBL] [Abstract][Full Text] [Related]
20. In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.
Aluisio L; Lord B; Barbier AJ; Fraser IC; Wilson SJ; Boggs J; Dvorak LK; Letavic MA; Maryanoff BE; Carruthers NI; Bonaventure P; Lovenberg TW
Eur J Pharmacol; 2008 Jun; 587(1-3):141-6. PubMed ID: 18499098
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
