BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

91 related articles for article (PubMed ID: 20462215)

  • 1. Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis.
    Pochetti G; Mitro N; Lavecchia A; Gilardi F; Besker N; Scotti E; Aschi M; Re N; Fracchiolla G; Laghezza A; Tortorella P; Montanari R; Novellino E; Mazza F; Crestani M; Loiodice F
    J Med Chem; 2010 Jun; 53(11):4354-66. PubMed ID: 20462215
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
    Porcelli L; Gilardi F; Laghezza A; Piemontese L; Mitro N; Azzariti A; Altieri F; Cervoni L; Fracchiolla G; Giudici M; Guerrini U; Lavecchia A; Montanari R; Di Giovanni C; Paradiso A; Pochetti G; Simone GM; Tortorella P; Crestani M; Loiodice F
    J Med Chem; 2012 Jan; 55(1):37-54. PubMed ID: 22081932
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma.
    Gani OA; Sylte I
    Chem Biol Drug Des; 2008 Jul; 72(1):50-7. PubMed ID: 18554251
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping.
    Sheu SH; Kaya T; Waxman DJ; Vajda S
    Biochemistry; 2005 Feb; 44(4):1193-209. PubMed ID: 15667213
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Peroxisome proliferator-activated receptor gamma inhibits follicular and anaplastic thyroid carcinoma cells growth by upregulating p21Cip1/WAF1 gene in a Sp1-dependent manner.
    Bonofiglio D; Qi H; Gabriele S; Catalano S; Aquila S; Belmonte M; Andò S
    Endocr Relat Cancer; 2008 Jun; 15(2):545-57. PubMed ID: 18509005
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Manipulation of reciprocal salt bridges at the heterodimerization interface alters the dimerization properties of mouse RXRalpha and PPARgamma1.
    Chan LS; Wells RA
    Biochem Biophys Res Commun; 2007 Jul; 358(4):1080-5. PubMed ID: 17521607
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids.
    Waku T; Shiraki T; Oyama T; Fujimoto Y; Maebara K; Kamiya N; Jingami H; Morikawa K
    J Mol Biol; 2009 Jan; 385(1):188-99. PubMed ID: 18977231
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells.
    Ogawa D; Nomiyama T; Nakamachi T; Heywood EB; Stone JF; Berger JP; Law RE; Bruemmer D
    Circ Res; 2006 Apr; 98(7):e50-9. PubMed ID: 16556873
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Helix 12 dynamics and thyroid hormone receptor activity: experimental and molecular dynamics studies of Ile280 mutants.
    Souza PC; Barra GB; Velasco LF; Ribeiro IC; Simeoni LA; Togashi M; Webb P; Neves FA; Skaf MS; Martínez L; Polikarpov I
    J Mol Biol; 2011 Oct; 412(5):882-93. PubMed ID: 21530542
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes.
    Mazzucotelli A; Viguerie N; Tiraby C; Annicotte JS; Mairal A; Klimcakova E; Lepin E; Delmar P; Dejean S; Tavernier G; Lefort C; Hidalgo J; Pineau T; Fajas L; Clément K; Langin D
    Diabetes; 2007 Oct; 56(10):2467-75. PubMed ID: 17646210
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of the amino-terminal domain in the interaction of unliganded peroxisome proliferator-activated receptor gamma-2 with nuclear receptor co-repressor.
    Suzuki S; Sasaki S; Morita H; Oki Y; Turiya D; Ito T; Misawa H; Ishizuka K; Nakamura H
    J Mol Endocrinol; 2010 Sep; 45(3):133-45. PubMed ID: 20587609
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rational discovery of a novel interface for a coactivator in the peroxisome proliferator-activated receptor gamma: theoretical implications of impairment in type 2 diabetes mellitus.
    Shiraki T; Kodama TS; Jingami H; Kamiya N
    Proteins; 2005 Feb; 58(2):418-25. PubMed ID: 15558556
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation.
    Ye F; Zhang ZS; Luo HB; Shen JH; Chen KX; Shen X; Jiang HL
    Chembiochem; 2006 Jan; 7(1):74-82. PubMed ID: 16317783
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A fluorescent indicator to visualize ligand-induced receptor/coactivator interactions for screening of peroxisome proliferator-activated receptor gamma ligands in living cells.
    Awais M; Sato M; Umezawa Y
    Biosens Bioelectron; 2007 May; 22(11):2564-9. PubMed ID: 17095203
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
    Pochetti G; Godio C; Mitro N; Caruso D; Galmozzi A; Scurati S; Loiodice F; Fracchiolla G; Tortorella P; Laghezza A; Lavecchia A; Novellino E; Mazza F; Crestani M
    J Biol Chem; 2007 Jun; 282(23):17314-24. PubMed ID: 17403688
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor gamma to PGC-1alpha.
    Li Y; Kovach A; Suino-Powell K; Martynowski D; Xu HE
    J Biol Chem; 2008 Jul; 283(27):19132-9. PubMed ID: 18469005
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Site-directed mutagenesis to study the role of specific amino acids in the ligand binding domain of PPARs.
    Mitro N; Gilardi F; Giudici M; Godio C; Scotti E; Crestani M
    Methods Mol Biol; 2013; 952():137-44. PubMed ID: 23100229
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists.
    Gim HJ; Cheon YJ; Ryu JH; Jeon R
    Bioorg Med Chem Lett; 2011 May; 21(10):3057-61. PubMed ID: 21482466
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Multi-conformation dynamic pharmacophore modeling of the peroxisome proliferator-activated receptor γ for the discovery of novel agonists.
    Sohn YS; Park C; Lee Y; Kim S; Thangapandian S; Kim Y; Kim HH; Suh JK; Lee KW
    J Mol Graph Model; 2013 Nov; 46():1-9. PubMed ID: 24104184
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ.
    Shang J; Brust R; Mosure SA; Bass J; Munoz-Tello P; Lin H; Hughes TS; Tang M; Ge Q; Kamenekca TM; Kojetin DJ
    Elife; 2018 Dec; 7():. PubMed ID: 30575522
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.