BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

434 related articles for article (PubMed ID: 20466847)

  • 1. Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.
    Leng S; Zhang W; Zheng Y; Liberman Z; Rhodes CJ; Eldar-Finkelman H; Sun XJ
    J Endocrinol; 2010 Aug; 206(2):171-81. PubMed ID: 20466847
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
    Copps KD; Hançer NJ; Qiu W; White MF
    J Biol Chem; 2016 Apr; 291(16):8602-17. PubMed ID: 26846849
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity.
    Mima A; Ohshiro Y; Kitada M; Matsumoto M; Geraldes P; Li C; Li Q; White GS; Cahill C; Rask-Madsen C; King GL
    Kidney Int; 2011 Apr; 79(8):883-96. PubMed ID: 21228767
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway.
    Alaaeldin R; Abdel-Rahman IAM; Hassan HA; Youssef N; Allam AE; Abdelwahab SF; Zhao QL; Fathy M
    Molecules; 2021 Dec; 26(24):. PubMed ID: 34946711
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Resistin disrupts glycogen synthesis under high insulin and high glucose levels by down-regulating the hepatic levels of GSK3β.
    Song R; Wang X; Mao Y; Li H; Li Z; Xu W; Wang R; Guo T; Jin L; Zhang X; Zhang Y; Zhou N; Hu R; Jia J; Lei Z; Irwin DM; Niu G; Tan H
    Gene; 2013 Oct; 529(1):50-6. PubMed ID: 23860320
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/Jng.
    Wang Y; Nishina PM; Naggert JK
    J Endocrinol; 2009 Oct; 203(1):65-74. PubMed ID: 19587264
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Artichoke (Cynara scolymus L.) water extract alleviates palmitate-induced insulin resistance in HepG2 hepatocytes via the activation of IRS1/PI3K/AKT/FoxO1 and GSK-3β signaling pathway.
    Deng A; Wang Y; Huang K; Xie P; Mo P; Liu F; Chen J; Chen K; Wang Y; Xiao B
    BMC Complement Med Ther; 2023 Dec; 23(1):460. PubMed ID: 38102588
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway
    Zhao H; Lu J; He F; Wang M; Yan Y; Chen B; Xie D; Xu C; Wang Q; Liu W; Yu W; Xi Y; Yu L; Yamamoto T; Koyama H; Wang W; Zhang C; Cheng J
    Front Immunol; 2022; 13():931087. PubMed ID: 36177037
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3.
    Kawaguchi T; Yoshida T; Harada M; Hisamoto T; Nagao Y; Ide T; Taniguchi E; Kumemura H; Hanada S; Maeyama M; Baba S; Koga H; Kumashiro R; Ueno T; Ogata H; Yoshimura A; Sata M
    Am J Pathol; 2004 Nov; 165(5):1499-508. PubMed ID: 15509521
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1.
    Zhande R; Mitchell JJ; Wu J; Sun XJ
    Mol Cell Biol; 2002 Feb; 22(4):1016-26. PubMed ID: 11809794
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Nitric oxide inhibits the proliferation and invasion of pancreatic cancer cells through degradation of insulin receptor substrate-1 protein.
    Sugita H; Kaneki M; Furuhashi S; Hirota M; Takamori H; Baba H
    Mol Cancer Res; 2010 Aug; 8(8):1152-63. PubMed ID: 20663861
    [TBL] [Abstract][Full Text] [Related]  

  • 12. IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.
    Potashnik R; Bloch-Damti A; Bashan N; Rudich A
    Diabetologia; 2003 May; 46(5):639-48. PubMed ID: 12750770
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.
    Tanioka T; Tamura Y; Fukaya M; Shinozaki S; Mao J; Kim M; Shimizu N; Kitamura T; Kaneki M
    J Biol Chem; 2011 Aug; 286(33):29388-29396. PubMed ID: 21700708
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle.
    Dokken BB; Sloniger JA; Henriksen EJ
    Am J Physiol Endocrinol Metab; 2005 Jun; 288(6):E1188-94. PubMed ID: 15671078
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Wheat germ peptide improves glucose metabolism and insulin resistance in HepG2 hepatocytes via regulating SOCS3/IRS1/Akt pathway.
    Song H; Huang Q; Zhang Y; Shen X
    Nutr Res; 2023 Dec; 120():135-144. PubMed ID: 38000279
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Signaling pathways mediating phosphorylation and inactivation of glycogen synthase kinase-3β by the recombinant human δ-opioid receptor stably expressed in Chinese hamster ovary cells.
    Olianas MC; Dedoni S; Onali P
    Neuropharmacology; 2011 Jun; 60(7-8):1326-36. PubMed ID: 21276805
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
    Valverde AM; Burks DJ; Fabregat I; Fisher TL; Carretero J; White MF; Benito M
    Diabetes; 2003 Sep; 52(9):2239-48. PubMed ID: 12941762
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A novel domain mediates insulin-induced proteasomal degradation of insulin receptor substrate 1 (IRS-1).
    Boura-Halfon S; Shuster-Meiseles T; Beck A; Petrovich K; Gurevitch D; Ronen D; Zick Y
    Mol Endocrinol; 2010 Nov; 24(11):2179-92. PubMed ID: 20843941
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Insulin receptor substrates 1 and 2 but not Shc can activate the insulin receptor independent of insulin and induce proliferation in CHO-IR cells.
    Niessen M; Jaschinski F; Item F; McNamara MP; Spinas GA; Trüb T
    Exp Cell Res; 2007 Feb; 313(4):805-15. PubMed ID: 17222824
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats.
    Zheng Y; Zhang W; Pendleton E; Leng S; Wu J; Chen R; Sun XJ
    J Endocrinol; 2009 Dec; 203(3):337-47. PubMed ID: 19801385
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 22.