88 related articles for article (PubMed ID: 20471844)
1. Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation.
Lavaggi ML; Cabrera M; Aravena Mde L; Olea-Azar C; López de Ceráin A; Monge A; Pachón G; Cascante M; Bruno AM; Pietrasanta LI; González M; Cerecetto H
Bioorg Med Chem; 2010 Jun; 18(12):4433-40. PubMed ID: 20471844
[TBL] [Abstract][Full Text] [Related]
2. Structural modifications on the phenazine N,N'-dioxide-scaffold looking for new selective hypoxic cytotoxins.
Lavaggi ML; Nieves M; Cabrera M; Olea-Azar C; López de Ceráin A; Monge A; Cerecetto H; González M
Eur J Med Chem; 2010 Nov; 45(11):5362-9. PubMed ID: 20846761
[TBL] [Abstract][Full Text] [Related]
3. Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins.
Cerecetto H; González M; Lavaggi ML; Azqueta A; López de Cerain A; Monge A
J Med Chem; 2005 Jan; 48(1):21-3. PubMed ID: 15633996
[TBL] [Abstract][Full Text] [Related]
4. Antitumoral effect of phenazine N5,N10-dioxide derivatives on Caco-2 cells.
Pachón OG; Azqueta A; Lavaggi ML; López de Cerain A; Creppy E; Collins A; Cerecetto H; González M; Centelles JJ; Cascante M
Chem Res Toxicol; 2008 Aug; 21(8):1578-85. PubMed ID: 18553946
[TBL] [Abstract][Full Text] [Related]
5. Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
Palmer BD; Wilson WR; Anderson RF; Boyd M; Denny WA
J Med Chem; 1996 Jun; 39(13):2518-28. PubMed ID: 8691449
[TBL] [Abstract][Full Text] [Related]
6. Cytotoxic palladium complexes of bioreductive quinoxaline N1,N4-dioxide prodrugs.
Urquiola C; Vieites M; Torre MH; Cabrera M; Lavaggi ML; Cerecetto H; González M; Cerain AL; Monge A; Smircich P; Garat B; Gambino D
Bioorg Med Chem; 2009 Feb; 17(4):1623-9. PubMed ID: 19162490
[TBL] [Abstract][Full Text] [Related]
7. Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies.
Cerecetto H; González M; Lavaggi ML; Aravena MA; Rigol C; Olea-Azar C; Azqueta A; de Cerain AL; Monge A; Bruno AM
Med Chem; 2006 Sep; 2(5):511-21. PubMed ID: 17017991
[TBL] [Abstract][Full Text] [Related]
8. DNA strand cleavage by the phenazine di-N-oxide natural product myxin under both aerobic and anaerobic conditions.
Chowdhury G; Sarkar U; Pullen S; Wilson WR; Rajapakse A; Fuchs-Knotts T; Gates KS
Chem Res Toxicol; 2012 Jan; 25(1):197-206. PubMed ID: 22084973
[TBL] [Abstract][Full Text] [Related]
9. DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.
Hay MP; Pruijn FB; Gamage SA; Liyanage HD; Kovacs MS; Patterson AV; Wilson WR; Brown JM; Denny WA
J Med Chem; 2004 Jan; 47(2):475-88. PubMed ID: 14711317
[TBL] [Abstract][Full Text] [Related]
10. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
Hay MP; Gamage SA; Kovacs MS; Pruijn FB; Anderson RF; Patterson AV; Wilson WR; Brown JM; Denny WA
J Med Chem; 2003 Jan; 46(1):169-82. PubMed ID: 12502371
[TBL] [Abstract][Full Text] [Related]
11. Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Xia Q; Zhang L; Zhang J; Sheng R; Yang B; He Q; Hu Y
Eur J Med Chem; 2011 Mar; 46(3):919-26. PubMed ID: 21281992
[TBL] [Abstract][Full Text] [Related]
12. Novel synthetic isoquinolino[5,4-ab]phenazines: inhibition toward topoisomerase I, antitumor and DNA photo-cleaving activities.
Yang P; Yang Q; Qian X; Cui J
Bioorg Med Chem; 2005 Nov; 13(21):5909-14. PubMed ID: 16115776
[TBL] [Abstract][Full Text] [Related]
13. Differential enzymatic reductions governing the differential hypoxia-selective cytotoxicities of phenazine 5,10-dioxides.
Lavaggi ML; Cabrera M; González M; Cerecetto H
Chem Res Toxicol; 2008 Sep; 21(9):1900-6. PubMed ID: 18661957
[TBL] [Abstract][Full Text] [Related]
14. 1, 2, 4-Triazine N-oxide derivatives: studies as potential hypoxic cytotoxins. Part III.
Cerecetto H; González M; Risso M; Saenz P; Olea-Azar C; Bruno AM; Azqueta A; De Ceráin AL; Monge A
Arch Pharm (Weinheim); 2004 May; 337(5):271-80. PubMed ID: 15095420
[TBL] [Abstract][Full Text] [Related]
15. The design of cobalt(III) complexes of phenazine-1-carboxamides as prointercalators and potential hypoxia-selective cytotoxins.
Perrin LC; Wilson WR; Denny WA; McFadyen WD
Anticancer Drug Des; 1999 Jun; 14(3):231-41. PubMed ID: 10500498
[TBL] [Abstract][Full Text] [Related]
16. Synthesis, structure and hypoxic cytotoxicity of 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Jiang F; Weng Q; Sheng R; Xia Q; He Q; Yang B; Hu Y
Arch Pharm (Weinheim); 2007 May; 340(5):258-63. PubMed ID: 17464965
[TBL] [Abstract][Full Text] [Related]
17. Phenazine-1-carboxamides: structure-cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain.
Gamage SA; Rewcastle GW; Baguley BC; Charlton PA; Denny WA
Bioorg Med Chem; 2006 Feb; 14(4):1160-8. PubMed ID: 16216514
[TBL] [Abstract][Full Text] [Related]
18. Synthesis of new pyrazolo[5,1-c][1,2,4] benzotriazines, pyrazolo[5,1-c]pyrido[4,3-e][1,2,4] triazines and their open analogues as cytotoxic agents in normoxic and hypoxic conditions.
Ciciani G; Coronnello M; Guerrini G; Selleri S; Cantore M; Failli P; Mini E; Costanzo A
Bioorg Med Chem; 2008 Nov; 16(21):9409-19. PubMed ID: 18845441
[TBL] [Abstract][Full Text] [Related]
19. Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity.
Lee HH; Wilson WR; Denny WA
Anticancer Drug Des; 1999 Dec; 14(6):487-97. PubMed ID: 10834270
[TBL] [Abstract][Full Text] [Related]
20. Hypoxic cells in tumors as a target for cancer therapy.
Gali-Muhtasib HU; Diab-Assef M; Haddadin MJ
J Med Liban; 2002; 50(4):175-9. PubMed ID: 15298478
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
