BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

365 related articles for article (PubMed ID: 20482315)

  • 1. Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases.
    Wolfe MS
    Biol Chem; 2010 Aug; 391(8):839-47. PubMed ID: 20482315
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.
    Iben LG; Olson RE; Balanda LA; Jayachandra S; Robertson BJ; Hay V; Corradi J; Prasad CV; Zaczek R; Albright CF; Toyn JH
    J Biol Chem; 2007 Dec; 282(51):36829-36. PubMed ID: 17932033
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Toward the structure of presenilin/γ-secretase and presenilin homologs.
    Wolfe MS
    Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
    Feilen LP; Chen SY; Fukumori A; Feederle R; Zacharias M; Steiner H
    Elife; 2022 May; 11():. PubMed ID: 35579427
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Secretase as a target for Alzheimer's disease.
    Wolfe MS
    Curr Top Med Chem; 2002 Apr; 2(4):371-83. PubMed ID: 11966461
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase.
    Tolia A; Horré K; De Strooper B
    J Biol Chem; 2008 Jul; 283(28):19793-803. PubMed ID: 18482978
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors.
    Weihofen A; Lemberg MK; Friedmann E; Rueeger H; Schmitz A; Paganetti P; Rovelli G; Martoglio B
    J Biol Chem; 2003 May; 278(19):16528-33. PubMed ID: 12621027
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
    Wolfe MS; De Los Angeles J; Miller DD; Xia W; Selkoe DJ
    Biochemistry; 1999 Aug; 38(35):11223-30. PubMed ID: 10471271
    [TBL] [Abstract][Full Text] [Related]  

  • 9. gamma-Secretase inhibitors as molecular probes of presenilin function.
    Wolfe MS
    J Mol Neurosci; 2001 Oct; 17(2):199-204. PubMed ID: 11816793
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.
    Cervantes S; Saura CA; Pomares E; Gonzàlez-Duarte R; Marfany G
    J Biol Chem; 2004 Aug; 279(35):36519-29. PubMed ID: 15220354
    [TBL] [Abstract][Full Text] [Related]  

  • 11. γ-Secretase inhibitors and modulators for Alzheimer's disease.
    Wolfe MS
    J Neurochem; 2012 Jan; 120 Suppl 1(Suppl 1):89-98. PubMed ID: 22122056
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel research horizons for presenilins and γ-secretases in cell biology and disease.
    De Strooper B; Annaert W
    Annu Rev Cell Dev Biol; 2010; 26():235-60. PubMed ID: 20604710
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural biology of presenilins and signal peptide peptidases.
    Tomita T; Iwatsubo T
    J Biol Chem; 2013 May; 288(21):14673-80. PubMed ID: 23585568
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Gamma-secretase--intramembrane protease with a complex.
    Wolfe MS
    Sci Aging Knowledge Environ; 2003 Mar; 2003(11):PE7. PubMed ID: 12844518
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The catalytic core of gamma-secretase: presenilin revisited.
    Steiner H
    Curr Alzheimer Res; 2008 Apr; 5(2):147-57. PubMed ID: 18393799
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Aspartic proteases in drug discovery.
    Eder J; Hommel U; Cumin F; Martoglio B; Gerhartz B
    Curr Pharm Des; 2007; 13(3):271-85. PubMed ID: 17313361
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
    Wolfe MS; Xia W; Moore CL; Leatherwood DD; Ostaszewski B; Rahmati T; Donkor IO; Selkoe DJ
    Biochemistry; 1999 Apr; 38(15):4720-7. PubMed ID: 10200159
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Expression, Purification, and Enzymatic Characterization of Intramembrane Proteases.
    Zhou R; Shi Y; Yang G
    Methods Enzymol; 2017; 584():127-155. PubMed ID: 28065261
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cellular functions of gamma-secretase-related proteins.
    Haffner C; Haass C
    Neurodegener Dis; 2006; 3(4-5):284-9. PubMed ID: 17047369
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Intramembrane proteolysis by presenilin and presenilin-like proteases.
    Xia W; Wolfe MS
    J Cell Sci; 2003 Jul; 116(Pt 14):2839-44. PubMed ID: 12808018
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.