BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

849 related articles for article (PubMed ID: 20485341)

  • 1. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
    Lin SC; Lo YC; Wu H
    Nature; 2010 Jun; 465(7300):885-90. PubMed ID: 20485341
    [TBL] [Abstract][Full Text] [Related]  

  • 2. MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.
    Moncrieffe MC; Bollschweiler D; Li B; Penczek PA; Hopkins L; Bryant CE; Klenerman D; Gay NJ
    Structure; 2020 Mar; 28(3):281-289.e3. PubMed ID: 31995744
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
    George J; Motshwene PG; Wang H; Kubarenko AV; Rautanen A; Mills TC; Hill AV; Gay NJ; Weber AN
    J Biol Chem; 2011 Jan; 286(2):1341-53. PubMed ID: 20966070
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling.
    De Nardo D; Balka KR; Cardona Gloria Y; Rao VR; Latz E; Masters SL
    J Biol Chem; 2018 Sep; 293(39):15195-15207. PubMed ID: 30076215
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases.
    Loiarro M; Gallo G; Fantò N; De Santis R; Carminati P; Ruggiero V; Sette C
    J Biol Chem; 2009 Oct; 284(41):28093-28103. PubMed ID: 19679662
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Oncogenically active MYD88 mutations in human lymphoma.
    Ngo VN; Young RM; Schmitz R; Jhavar S; Xiao W; Lim KH; Kohlhammer H; Xu W; Yang Y; Zhao H; Shaffer AL; Romesser P; Wright G; Powell J; Rosenwald A; Muller-Hermelink HK; Ott G; Gascoyne RD; Connors JM; Rimsza LM; Campo E; Jaffe ES; Delabie J; Smeland EB; Fisher RI; Braziel RM; Tubbs RR; Cook JR; Weisenburger DD; Chan WC; Staudt LM
    Nature; 2011 Feb; 470(7332):115-9. PubMed ID: 21179087
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Small Molecule Mimetics of α-Helical Domain of IRAK2 Attenuate the Proinflammatory Effects of IL-33 in Asthma-like Mouse Models.
    Li J; Saruta K; Dumouchel JP; Magat JM; Thomas JL; Ajami D; Rebek M; Rebek J; Bigby TD
    J Immunol; 2018 Jun; 200(12):4036-4043. PubMed ID: 29728508
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure of human IRAK1.
    Wang L; Qiao Q; Ferrao R; Shen C; Hatcher JM; Buhrlage SJ; Gray NS; Wu H
    Proc Natl Acad Sci U S A; 2017 Dec; 114(51):13507-13512. PubMed ID: 29208712
    [TBL] [Abstract][Full Text] [Related]  

  • 9. IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly.
    Ferrao R; Zhou H; Shan Y; Liu Q; Li Q; Shaw DE; Li X; Wu H
    Mol Cell; 2014 Sep; 55(6):891-903. PubMed ID: 25201411
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists.
    Vollmer S; Strickson S; Zhang T; Gray N; Lee KL; Rao VR; Cohen P
    Biochem J; 2017 Jun; 474(12):2027-2038. PubMed ID: 28512203
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Examining Myddosome Formation by Luminescence-Based Mammalian Interactome Mapping (LUMIER).
    Wolz OO; Koegl M; Weber ANR
    Methods Mol Biol; 2018; 1714():119-130. PubMed ID: 29177859
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A noncanonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling.
    Li Y; Shah RB; Sarti S; Belcher AL; Lee BJ; Gorbatenko A; Nemati F; Yu H; Stanley Z; Rahman M; Shao Z; Silva JM; Zha S; Sidi S
    Sci Signal; 2023 Dec; 16(816):eadh3449. PubMed ID: 38113335
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling.
    De S; Karim F; Kiessu E; Cushing L; Lin LL; Ghandil P; Hoarau C; Casanova JL; Puel A; Rao VR
    J Biol Chem; 2018 Sep; 293(39):15208-15220. PubMed ID: 30115681
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound.
    Loiarro M; Capolunghi F; Fantò N; Gallo G; Campo S; Arseni B; Carsetti R; Carminati P; De Santis R; Ruggiero V; Sette C
    J Leukoc Biol; 2007 Oct; 82(4):801-10. PubMed ID: 17548806
    [TBL] [Abstract][Full Text] [Related]  

  • 15. IRAK4 in TLR/IL-1R signaling: possible clinical applications.
    Li X
    Eur J Immunol; 2008 Mar; 38(3):614-8. PubMed ID: 18286571
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner.
    Cushing L; Stochaj W; Siegel M; Czerwinski R; Dower K; Wright Q; Hirschfield M; Casanova JL; Picard C; Puel A; Lin LL; Rao VR
    J Biol Chem; 2014 Apr; 289(15):10865-10875. PubMed ID: 24567333
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold.
    Dossang AC; Motshwene PG; Yang Y; Symmons MF; Bryant CE; Borman S; George J; Weber AN; Gay NJ
    Sci Rep; 2016 Nov; 6():37267. PubMed ID: 27876844
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism of MyD88S mediated signal termination.
    Pustelny K; Kuska K; Gorecki A; Musielak B; Dobosz E; Wladyka B; Koziel J; Czarna A; Holak T; Dubin G
    Cell Commun Signal; 2022 Jan; 20(1):10. PubMed ID: 35057808
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
    Fernandes-Alnemri T; Kang S; Anderson C; Sagara J; Fitzgerald KA; Alnemri ES
    J Immunol; 2013 Oct; 191(8):3995-9. PubMed ID: 24043892
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Functional assessment of the mutational effects of human IRAK4 and MyD88 genes.
    Yamamoto T; Tsutsumi N; Tochio H; Ohnishi H; Kubota K; Kato Z; Shirakawa M; Kondo N
    Mol Immunol; 2014 Mar; 58(1):66-76. PubMed ID: 24316379
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 43.