BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1029 related articles for article (PubMed ID: 20486766)

  • 1. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.
    Villeneuve NF; Lau A; Zhang DD
    Antioxid Redox Signal; 2010 Dec; 13(11):1699-712. PubMed ID: 20486766
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
    Kobayashi A; Kang MI; Okawa H; Ohtsuji M; Zenke Y; Chiba T; Igarashi K; Yamamoto M
    Mol Cell Biol; 2004 Aug; 24(16):7130-9. PubMed ID: 15282312
    [TBL] [Abstract][Full Text] [Related]  

  • 3. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
    Furukawa M; Xiong Y
    Mol Cell Biol; 2005 Jan; 25(1):162-71. PubMed ID: 15601839
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.
    Lo SC; Hannink M
    Mol Cell Biol; 2006 Feb; 26(4):1235-44. PubMed ID: 16449638
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
    Zhang DD; Lo SC; Cross JV; Templeton DJ; Hannink M
    Mol Cell Biol; 2004 Dec; 24(24):10941-53. PubMed ID: 15572695
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2.
    McMahon M; Swift SR; Hayes JD
    Toxicol Appl Pharmacol; 2018 Dec; 360():45-57. PubMed ID: 30261176
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
    Lau A; Wang XJ; Zhao F; Villeneuve NF; Wu T; Jiang T; Sun Z; White E; Zhang DD
    Mol Cell Biol; 2010 Jul; 30(13):3275-85. PubMed ID: 20421418
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
    Zhang DD; Lo SC; Sun Z; Habib GM; Lieberman MW; Hannink M
    J Biol Chem; 2005 Aug; 280(34):30091-9. PubMed ID: 15983046
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A; Motohashi H
    Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer.
    Martinez VD; Vucic EA; Thu KL; Pikor LA; Hubaux R; Lam WL
    Biomed Res Int; 2014; 2014():159459. PubMed ID: 25114896
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CRL3s: The BTB-CUL3-RING E3 Ubiquitin Ligases.
    Wang P; Song J; Ye D
    Adv Exp Med Biol; 2020; 1217():211-223. PubMed ID: 31898230
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Keap1-Nrf2 system and diabetes mellitus.
    Uruno A; Yagishita Y; Yamamoto M
    Arch Biochem Biophys; 2015 Jan; 566():76-84. PubMed ID: 25528168
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications.
    Keum YS
    Ann N Y Acad Sci; 2011 Jul; 1229():184-9. PubMed ID: 21793854
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
    Baird L; Dinkova-Kostova AT
    Biochem Biophys Res Commun; 2013 Mar; 433(1):58-65. PubMed ID: 23454126
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.
    Taguchi K; Motohashi H; Yamamoto M
    Genes Cells; 2011 Feb; 16(2):123-40. PubMed ID: 21251164
    [TBL] [Abstract][Full Text] [Related]  

  • 16. p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex.
    Tao S; Liu P; Luo G; Rojo de la Vega M; Chen H; Wu T; Tillotson J; Chapman E; Zhang DD
    Mol Cell Biol; 2017 Apr; 37(8):. PubMed ID: 28115426
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction.
    Nguyen HC; Wang W; Xiong Y
    Subcell Biochem; 2017; 83():323-347. PubMed ID: 28271482
    [TBL] [Abstract][Full Text] [Related]  

  • 18. USP15 negatively regulates Nrf2 through deubiquitination of Keap1.
    Villeneuve NF; Tian W; Wu T; Sun Z; Lau A; Chapman E; Fang D; Zhang DD
    Mol Cell; 2013 Jul; 51(1):68-79. PubMed ID: 23727018
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer.
    Martinez VD; Vucic EA; Pikor LA; Thu KL; Hubaux R; Lam WL
    Mol Cancer; 2013 Oct; 12(1):124. PubMed ID: 24138990
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.
    Kaspar JW; Niture SK; Jaiswal AK
    J Cell Sci; 2012 Feb; 125(Pt 4):1027-38. PubMed ID: 22448038
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 52.