BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

186 related articles for article (PubMed ID: 20489208)

  • 21. Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia.
    Kojima K; Konopleva M; Tsao T; Nakakuma H; Andreeff M
    Blood; 2008 Oct; 112(7):2886-95. PubMed ID: 18633130
    [TBL] [Abstract][Full Text] [Related]  

  • 22. The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function.
    Gizatullin F; Yao Y; Kung V; Harding MW; Loda M; Shapiro GI
    Cancer Res; 2006 Aug; 66(15):7668-77. PubMed ID: 16885368
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Differential regulation of p21 (waf1) protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications.
    Chang LJ; Eastman A
    Cancer Biol Ther; 2012 Sep; 13(11):1047-57. PubMed ID: 22825333
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity.
    Sriraman A; Radovanovic M; Wienken M; Najafova Z; Li Y; Dobbelstein M
    Oncotarget; 2016 May; 7(22):31623-38. PubMed ID: 27183917
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Nutlin-3 affects expression and function of retinoblastoma protein: role of retinoblastoma protein in cellular response to nutlin-3.
    Du W; Wu J; Walsh EM; Zhang Y; Chen CY; Xiao ZX
    J Biol Chem; 2009 Sep; 284(39):26315-21. PubMed ID: 19648117
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.
    Korotchkina LG; Leontieva OV; Bukreeva EI; Demidenko ZN; Gudkov AV; Blagosklonny MV
    Aging (Albany NY); 2010 Jun; 2(6):344-52. PubMed ID: 20606252
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells.
    Secchiero P; Zerbinati C; di Iasio MG; Melloni E; Tiribelli M; Grill V; Zauli G
    Curr Drug Metab; 2007 May; 8(4):395-403. PubMed ID: 17504227
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways.
    Shimazu K; Tada Y; Morinaga T; Shingyoji M; Sekine I; Shimada H; Hiroshima K; Namiki T; Tatsumi K; Tagawa M
    BMC Cancer; 2017 May; 17(1):309. PubMed ID: 28464864
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.
    Ambrosini G; Sambol EB; Carvajal D; Vassilev LT; Singer S; Schwartz GK
    Oncogene; 2007 May; 26(24):3473-81. PubMed ID: 17146434
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.
    Endo S; Yamato K; Hirai S; Moriwaki T; Fukuda K; Suzuki H; Abei M; Nakagawa I; Hyodo I
    Cancer Sci; 2011 Mar; 102(3):605-13. PubMed ID: 21205074
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.
    Saha MN; Jiang H; Chang H
    Cancer Biol Ther; 2010 Sep; 10(6):567-78. PubMed ID: 20595817
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells.
    Huang B; Deo D; Xia M; Vassilev LT
    Mol Cancer Res; 2009 Sep; 7(9):1497-509. PubMed ID: 19737973
    [TBL] [Abstract][Full Text] [Related]  

  • 33. MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells.
    Wang B; Fang L; Zhao H; Xiang T; Wang D
    Acta Biochim Biophys Sin (Shanghai); 2012 Aug; 44(8):685-91. PubMed ID: 22843172
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Epithelial cell adhesion molecule targeted nutlin-3a loaded immunonanoparticles for cancer therapy.
    Das M; Sahoo SK
    Acta Biomater; 2011 Jan; 7(1):355-69. PubMed ID: 20727991
    [TBL] [Abstract][Full Text] [Related]  

  • 35. p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation.
    Xia M; Knezevic D; Vassilev LT
    Oncogene; 2011 Jan; 30(3):346-55. PubMed ID: 20871630
    [TBL] [Abstract][Full Text] [Related]  

  • 36. P53 activation suppresses irinotecan metabolite SN-38-induced cell damage in non-malignant but not malignant epithelial colonic cells.
    Gunasegaran B; Neilsen PM; Smid SD
    Toxicol In Vitro; 2020 Sep; 67():104908. PubMed ID: 32502622
    [TBL] [Abstract][Full Text] [Related]  

  • 37. TRIAD1 Is a Novel Transcriptional Target of p53 and Regulates Nutlin-3a-Induced Cell Death.
    Lee J; An S; Choi YM; Jung JH; Li L; Meng H; Dong Y; Ahn KJ; An IS; Bae S
    J Cell Biochem; 2017 Jul; 118(7):1733-1740. PubMed ID: 27935098
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Nutlin-3a as a novel anticancer agent for adrenocortical carcinoma with CTNNB1 mutation.
    Hui W; Liu S; Zheng J; Fang Z; Ding Q; Feng C
    Cancer Med; 2018 Apr; 7(4):1440-1449. PubMed ID: 29532999
    [TBL] [Abstract][Full Text] [Related]  

  • 39. p53-mediated growth suppression in response to Nutlin-3 in cyclin D1 transformed cells occurs independently of p21.
    Kan CE; Patton JT; Stark GR; Jackson MW
    Cancer Res; 2007 Oct; 67(20):9862-8. PubMed ID: 17942917
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells.
    Renouf B; Hollville E; Pujals A; Tétaud C; Garibal J; Wiels J
    Leukemia; 2009 Sep; 23(9):1557-63. PubMed ID: 19421231
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.