208 related articles for article (PubMed ID: 20491440)
1. Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.
Souto JA; Vaz E; Lepore I; Pöppler AC; Franci G; Alvarez R; Altucci L; de Lera AR
J Med Chem; 2010 Jun; 53(12):4654-67. PubMed ID: 20491440
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and biological evaluation of c7-demethyl largazole analogues.
Chen F; Gao AH; Li J; Nan FJ
ChemMedChem; 2009 Aug; 4(8):1269-72. PubMed ID: 19431162
[No Abstract] [Full Text] [Related]
3. Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.
Mai A; Massa S; Rotili D; Simeoni S; Ragno R; Botta G; Nebbioso A; Miceli M; Altucci L; Brosch G
J Med Chem; 2006 Oct; 49(20):6046-56. PubMed ID: 17004718
[TBL] [Abstract][Full Text] [Related]
4. Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.
Benelkebir H; Marie S; Hayden AL; Lyle J; Loadman PM; Crabb SJ; Packham G; Ganesan A
Bioorg Med Chem; 2011 Jun; 19(12):3650-8. PubMed ID: 21420302
[TBL] [Abstract][Full Text] [Related]
5. Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.
Ying Y; Taori K; Kim H; Hong J; Luesch H
J Am Chem Soc; 2008 Jul; 130(26):8455-9. PubMed ID: 18507379
[TBL] [Abstract][Full Text] [Related]
6. Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity.
Mai A; Valente S; Rotili D; Massa S; Botta G; Brosch G; Miceli M; Nebbioso A; Altucci L
Int J Biochem Cell Biol; 2007; 39(7-8):1510-22. PubMed ID: 17482499
[TBL] [Abstract][Full Text] [Related]
7. Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.
Bhansali P; Hanigan CL; Casero RA; Tillekeratne LM
J Med Chem; 2011 Nov; 54(21):7453-63. PubMed ID: 21936551
[TBL] [Abstract][Full Text] [Related]
8. Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.
Ontoria JM; Altamura S; Di Marco A; Ferrigno F; Laufer R; Muraglia E; Palumbi MC; Rowley M; Scarpelli R; Schultz-Fademrecht C; Serafini S; Steinkühler C; Jones P
J Med Chem; 2009 Nov; 52(21):6782-9. PubMed ID: 19888759
[TBL] [Abstract][Full Text] [Related]
9. Bispyridinium dienes: histone deacetylase inhibitors with selective activities.
Pérez-Balado C; Nebbioso A; Rodríguez-Graña P; Minichiello A; Miceli M; Altucci L; de Lera AR
J Med Chem; 2007 May; 50(10):2497-505. PubMed ID: 17447750
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups.
Bhansali P; Hanigan CL; Perera L; Casero RA; Tillekeratne LM
Eur J Med Chem; 2014 Oct; 86():528-41. PubMed ID: 25203782
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and biological evaluation of largazole zinc-binding group analogs.
Kim B; Ratnayake R; Lee H; Shi G; Zeller SL; Li C; Luesch H; Hong J
Bioorg Med Chem; 2017 Jun; 25(12):3077-3086. PubMed ID: 28416100
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents.
Su H; Nebbioso A; Carafa V; Chen Y; Yang B; Altucci L; You Q
Bioorg Med Chem; 2008 Sep; 16(17):7992-8002. PubMed ID: 18701301
[TBL] [Abstract][Full Text] [Related]
13. Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.
Poli G; Di Fabio R; Ferrante L; Summa V; Botta M
ChemMedChem; 2017 Dec; 12(23):1917-1926. PubMed ID: 29117473
[TBL] [Abstract][Full Text] [Related]
14. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.
Suzuki T; Nagano Y; Kouketsu A; Matsuura A; Maruyama S; Kurotaki M; Nakagawa H; Miyata N
J Med Chem; 2005 Feb; 48(4):1019-32. PubMed ID: 15715470
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and activity of largazole analogues with linker and macrocycle modification.
Ying Y; Liu Y; Byeon SR; Kim H; Luesch H; Hong J
Org Lett; 2008 Sep; 10(18):4021-4. PubMed ID: 18707106
[TBL] [Abstract][Full Text] [Related]
16. Evaluation of class I HDAC isoform selectivity of largazole analogues.
Kim B; Park H; Salvador LA; Serrano PE; Kwan JC; Zeller SL; Chen QY; Ryu S; Liu Y; Byeon S; Luesch H; Hong J
Bioorg Med Chem Lett; 2014 Aug; 24(16):3728-31. PubMed ID: 25070421
[TBL] [Abstract][Full Text] [Related]
17. 2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.
Mahboobi S; Sellmer A; Höcher H; Garhammer C; Pongratz H; Maier T; Ciossek T; Beckers T
J Med Chem; 2007 Sep; 50(18):4405-18. PubMed ID: 17691763
[TBL] [Abstract][Full Text] [Related]
18. Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.
Almaliti J; Al-Hamashi AA; Negmeldin AT; Hanigan CL; Perera L; Pflum MK; Casero RA; Tillekeratne LM
J Med Chem; 2016 Dec; 59(23):10642-10660. PubMed ID: 27809521
[TBL] [Abstract][Full Text] [Related]
19. Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors.
Reddy DN; Ballante F; Chuang T; Pirolli A; Marrocco B; Marshall GR
J Med Chem; 2016 Feb; 59(4):1613-33. PubMed ID: 26681404
[TBL] [Abstract][Full Text] [Related]
20. tert-Butylcarbamate-containing histone deacetylase inhibitors: apoptosis induction, cytodifferentiation, and antiproliferative activities in cancer cells.
Valente S; Trisciuoglio D; Tardugno M; Benedetti R; Labella D; Secci D; Mercurio C; Boggio R; Tomassi S; Di Maro S; Novellino E; Altucci L; Del Bufalo D; Mai A; Cosconati S
ChemMedChem; 2013 May; 8(5):800-11. PubMed ID: 23526814
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]