These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

194 related articles for article (PubMed ID: 20504912)

  • 1. Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor.
    Chen Y; Tang Y; Robbins GT; Nie D
    J Pharmacol Exp Ther; 2010 Sep; 334(3):999-1008. PubMed ID: 20504912
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Differences in the induction of cytochrome P450 3A4 by taxane anticancer drugs, docetaxel and paclitaxel, assessed employing primary human hepatocytes.
    Nallani SC; Goodwin B; Buckley AR; Buckley DJ; Desai PB
    Cancer Chemother Pharmacol; 2004 Sep; 54(3):219-29. PubMed ID: 15175893
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.
    Wang YM; Lin W; Chai SC; Wu J; Ong SS; Schuetz EG; Chen T
    Toxicol Appl Pharmacol; 2013 Oct; 272(1):96-107. PubMed ID: 23707768
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor.
    Chen Y; Tang Y; Nie JZ; Zhang Y; Nie D
    Cancer Chemother Pharmacol; 2021 Dec; 88(6):985-996. PubMed ID: 34524495
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes.
    Drocourt L; Pascussi JM; Assenat E; Fabre JM; Maurel P; Vilarem MJ
    Drug Metab Dispos; 2001 Oct; 29(10):1325-31. PubMed ID: 11560876
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.
    Banerjee M; Chen T
    Biochem Pharmacol; 2014 Nov; 92(2):389-402. PubMed ID: 25181459
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.
    Ma X; Cheung C; Krausz KW; Shah YM; Wang T; Idle JR; Gonzalez FJ
    Drug Metab Dispos; 2008 Dec; 36(12):2506-12. PubMed ID: 18799805
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.
    Lin W; Wu J; Dong H; Bouck D; Zeng FY; Chen T
    J Biol Chem; 2008 Nov; 283(45):30650-7. PubMed ID: 18784074
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor.
    Ding X; Lichti K; Staudinger JL
    Toxicol Sci; 2006 Jun; 91(2):448-55. PubMed ID: 16547076
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Li T; Chiang JY
    Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1.
    Lim YP; Huang JD
    Pharmacogenet Genomics; 2007 May; 17(5):369-82. PubMed ID: 17429319
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L; Svecova L; Anzenbacherova E; Vrzal R; Staud F; Dvorak Z; Ulrichova J; Anzenbacher P; Pavek P
    Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2.
    Rhodes SP; Otten JN; Hingorani GP; Hartley DP; Franklin RB
    J Pharmacol Toxicol Methods; 2011; 63(3):223-6. PubMed ID: 21111054
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.
    Faucette SR; Wang H; Hamilton GA; Jolley SL; Gilbert D; Lindley C; Yan B; Negishi M; LeCluyse EL
    Drug Metab Dispos; 2004 Mar; 32(3):348-58. PubMed ID: 14977870
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.
    Yang J; Luan X; Gui H; Yan P; Yang D; Song X; Liu W; Hu G; Yan B
    Br J Pharmacol; 2011 Jan; 162(2):441-51. PubMed ID: 20942813
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate.
    Nallani SC; Glauser TA; Hariparsad N; Setchell K; Buckley DJ; Buckley AR; Desai PB
    Epilepsia; 2003 Dec; 44(12):1521-8. PubMed ID: 14636322
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents.
    Mani S; Huang H; Sundarababu S; Liu W; Kalpana G; Smith AB; Horwitz SB
    Clin Cancer Res; 2005 Sep; 11(17):6359-69. PubMed ID: 16144941
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Impact of ritonavir, atazanavir and their combination on the CYP3A4 induction potential of efavirenz in primary human hepatocytes.
    Mugundu GM; Hariparsad N; Desai PB
    Drug Metab Lett; 2010 Jan; 4(1):45-50. PubMed ID: 20201776
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
    Koyano S; Kurose K; Saito Y; Ozawa S; Hasegawa R; Komamura K; Ueno K; Kamakura S; Kitakaze M; Nakajima T; Matsumoto K; Akasawa A; Saito H; Sawada J
    Drug Metab Dispos; 2004 Jan; 32(1):149-54. PubMed ID: 14709632
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.
    Faucette SR; Sueyoshi T; Smith CM; Negishi M; Lecluyse EL; Wang H
    J Pharmacol Exp Ther; 2006 Jun; 317(3):1200-9. PubMed ID: 16513849
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.